Structural features comparison of the proteomes in the three superkingdoms
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In this study the researchers used Super-Resolution Microscopy in order to attempt to understand the gag proteins and envelope recruitment and how exactly the HIV-1 virus is incorporated into the cell (which was previously not known). They were able to see the GAG assembly sites along with teh HIV-1 envelope proteins in the envelope expressing cells. It was discovered that the envelope accumulation outside of and surrounding the GAG assemblies (rather than directly being in contact with it) was able to assist the spread of the virus in vivo.