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2016

Note - Stem Cell Practical - Exercise

2016 Lab 11

As part of the assessment for this course, your group will give a 15 minutes journal club presentation during the Lab on 26 May. For this you will have to discuss a recent (published after 2011) original research article on stem cell biology or technology, regenerative medicine, or stem cell therapy published in a high quality international research journal. Please note, reviews are not allowed.

Please search on PubMed for 2-3 research articles using search relevant terms, and send their PDFs to Annemiek (A.Beverdam@unsw.edu.au) by 5 pm on Wednesday 18 May. She will inform you which of the chosen articles are best suitable for presentation by Friday 20 May latest. Please note that the most exciting research articles are found in journals such as Nature, Science, Cell, Cell Stem Cell, etc. Please contact Annemiek in case you are at a loss, and she will help you find one.

During the presentation it works best if one student discusses the introduction, the second the results section, and the third the discussion section. Please note that one slide takes about 1 minute to talk through. So do not use more than 15 slides total. Please read through attached document for tips for how to prepare a good presentation. To make the Lab more interactive, I expect that each group will ask at least one question after each presentation.

You will receive a group mark based on presentation content, insight and comprehension, presentation and slide style, keeping within time, and contribution to discussion and questions.

Search PubMed: stem cell


Regulation of steroid hormone receptors and coregulators during the cell cycle highlights potential novel function in addition to roles as transcription factors

Nucl Recept Signal. 2016 Jan 13;14:e001. doi: 10.1621/nrs.14001. eCollection 2016.

Zheng Y1, Murphy LC1.

Abstract Cell cycle progression is tightly controlled by several kinase families including Cyclin-Dependent Kinases, Polo-Like Kinases, and Aurora Kinases. A large amount of data show that steroid hormone receptors and various components of the cell cycle, including cell cycle regulated kinases, interact, and this often results in altered transcriptional activity of the receptor. Furthermore, steroid hormones, through their receptors, can also regulate the transcriptional expression of genes that are required for cell cycle regulation. However, emerging data suggest that steroid hormone receptors may have roles in cell cycle progression independent of their transcriptional activity. The following is a review of how steroid receptors and their coregulators can regulate or be regulated by the cell cycle machinery, with a particular focus on roles independent of transcription in G2/M. KEYWORDS: cell cycle; kinases; mitosis; phosphorylation; steroid hormone receptors; transcription-independent action PMID 26778927

2011

Adhesion molecule signalling: not always a sticky business

Nat Rev Mol Cell Biol. 2011 Mar;12(3):189-97.

Cavallaro U, Dejana E. Source Cell Adhesion and Signalling, FIRC Institute of Molecular Oncology (IFOM), Via Adamello 16, 20139 Milan, Italy. ugo.cavallaro@ifom-ieo-campus.it

Abstract

The signalling activity of cell adhesion molecules (CAMs) such as cadherins, immunoglobulin-like CAMs or integrins has long been considered to be a direct consequence of their adhesive properties. However, there are physiological and pathological processes that reduce or even abrogate the adhesive properties of CAMs, such as cleavage, conformational changes, mutations and shedding. In some cases these 'adhesion deficient' CAMs still retain signalling properties through their cytoplasmic domains and/or their mutated or truncated extracellular domains. The ability of CAMs to activate signal transduction cascades in the absence of cell adhesion significantly extends their range of biological activities.

PMID: 21346732 http://www.ncbi.nlm.nih.gov/pubmed/21346732