From CellBiology
Revision as of 19:57, 21 May 2009 by Z3187155 (talk | contribs)

A)In the structure part of the project, I think it needs to be focused specifically on structure of the protein. Structure part was bit lengthy and it made distracted. Those below copies are from the structure part, it would be better if these were moved to the clinical part and mechanisms part accordingly.

The disruption of this ubiquitous structures can cause acute promyelocytic leukemia (APL) and in DNA virus infection whereby the virus encode a protein and distrupt the NBs. SP100 protein and PML are covalently modified by the small ubiquitin-related protein SUMO-1. The modification requires nuclear localisation signal (NLS) and involves some lysine residue.

SP100 is also known to bind and interact with the members of heterochromatin protein 1 (HP1) families of non-histone chromosomal proteins. This protein present targets for the process of transcription, DNA replication and repair

B) z3280894- I agree that your project is lengthy but I think if you were to create more subheadings rather than just the two it would seem more broken up and easier to read. Maybe create a function subheading and also a glossary. Also, check to see if your pictures are labeled correctly with copyright information.

c) I agree with the above... perhaps some more information about the function and dynamics of the protein... also, paragraph 1 of the introduction contains a fragamented sentence:

SP100 is part of the component in the nuclear body that may involve during the immune response by regulating the transcription process

D) z3132868: You might want to put the history part in the introduction as to what people have discovered about this protein in the past, and then conclude the project by providing some current research and further research. The big chunks of words made it quite difficult to follow and understand, you might want to break it down into subheadings.

It shouldnt take too much to make this into a presentable body of work since you've obviously dont the readings. --Peter Kehoe 12:44, 21 May 2009 (EST)

E) You might like to consider the following suggestions. Firstly, reconstruct your page. ie. Relocate history under introduction. Secondly, reorganise subheadings. ie."Overview of SP 100, Historical background of SP100, Structure and Function of SP100, blah, blah". Thirdly, focusing on functional aspect of the SP100, such as function of SP100, current research on SP100. Fourthly, you might like to devote a section to link your individual topic to group topic. eg."SP100 is such a cool protein, because it plays an essential in nucleus, blah, blah..". One more thing, condense your materials, just to make it easy to read. Overall, a good page

F) Whats been said above pretty much covers everything I've got to say. Maybe put your homework on this page so that it doesn't clutter up your assignment page. Good page.

--Mark Hill 10:00, 20 April 2009 (EST) You have not yet selected your individual project protein/method topic and still missing some homework items. 2009_Student#Individual_Projects Individual Projects

--Mark Hill 18:35, 19 March 2009 (EST)You still need to provide feedback for Lecture 4 - Nucleus.

--Mark Hill 00:14, 31 March 2009 (EST) Thank you for your feedback on the Nucleus lecture, "It is one of the main component of eukaryotic cell", not a very insightful comment about the nucleus. I was after something you may not have known about the nucleus or found interesting.

--Mark Hill 22:39, 31 March 2009 (EST) Nucleus information is much better now. You have made the effort to think about the lecture content, well done. Though I don't know what "and regulate the whole body's function respectively." means exactly? Now you just need to add the other homework topics. Homework

--Mark Hill 10:38, 3 April 2009 (EST) Your energy answer is OK, I was more after specific cellular processes (like intracellular transport) so that you would see that mitochondria locate where energy consumption is highest. You still need to answer the other homework questions. 2009_Student#Individual_Projects