Difference between revisions of "Talk:3219606"

From CellBiology
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==Lecture 4 - The nucleus.==
  
Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis.
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I found the nuclear lamins really interesting. They are only found in the nucleus and assemble and disassemble during mitosis/meiosis. The lamins are pegged around the nucleus and I think it is interesting how they contribute to the structure of the nucleus. A mutation can lead to the nucleus being folded with an unstable structure - Hutchinson-GUildford Progeria syndrome.
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[edit] Lecture 5 - Exocytosis.
  
Gewies A, Grimm S.
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==exocytosis==
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I find exocytosis process simple to follow. The golgi apparatus however was a bit complex in understanding. The cisternae have no direct communication with each other and each cisternae contains different modification enzymes. The vesicles fuse at different layers of the golgi for modification. Where and for what reason they do this confused me.
  
Br J Cancer. 2003 Oct 20;89(8):1574-80.
 
  
PMID: 14562034 [PubMed - indexed for MEDLINE]
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==The Mitochondria.==
  
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Mitochondria are the energy generators for cells. They create energy through a process called cellular respiration or oxidative phosphorylation. They have an important enzyme called ATPase which helps convert oxygen and nutrients into ATP. Apart from generating energy, the mitochondria can also synthesis proteins and replicate DNA. It is also important for storage of calcium ions.
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[edit] CAM types
  
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==Ancronyms==
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N-CAM: Neural Cell Adhesion Molecule
  
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Ng-CAM: Neuron-glia Cell Adhesion Molecule
  
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L-CAM: Liver Cell Adhesion Molecule
  
Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting.
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I-CAM: Intercellular Cell Adhesion Molecule
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[edit] Lecture 10
  
Deval C, Mordier S, Obled C, Bechet D, Combaret L, Attaix D, Ferrara M.
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==What is the name of the epidermal layer between the basal and granulosa layer and how does it relate to intermediate filaments?==
 
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The epidermal layer between the basal and granulosa layer is the stratum spinosum. the stratum spinosum has cuboidal cells that are joined together by desmosomes. These cells actively synthesize intermediate filaments called cytokeratins which are anchored to the desmosomes providing structural support to the skin.
Biochem J. 2001 Nov 15;360(Pt 1):143-50.
 
 
 
PMID: 11696001 [PubMed - indexed for MEDLINE]
 
 
 
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*changes
 
However, I found some interesting information on cathepsin B as well.
 
 
 
 
 
Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells.
 
 
 
Foghsgaard L, Lademann U, Wissing D, Poulsen B, Jaattela M.
 
 
 
J Biol Chem. 2002 Oct 18;277(42):39499-506. Epub 2002 Aug 15.
 
 
 
PMID: 12185082 [PubMed - indexed for MEDLINE]
 
 
 
Related Articles Free article at journal site
 

Revision as of 19:13, 17 May 2009

You have now created your individual project page.

--Mark Hill 09:56, 20 April 2009 (EST) You have not yet selected your individual project protein/method topic and still missing some homework items. 2009_Student#Individual_Projects Individual Projects

--Mark Hill 18:33, 19 March 2009 (EST)You still need to provide feedback for Lecture 4 - Nucleus.

--Mark Hill 22:37, 30 March 2009 (EST) Thank you for your feedback on the nucleus, you now have some understanding of nuclear structure and its regulation by the internal skeleton. Now you have to complete the second part, which was to feedback What you found difficult to understand about Lecture 5 Exocytosis. Mmmmnnnn. spaghetti!

--Mark Hill 09:53, 3 April 2009 (EST)Thank your for your feedback. I was really after the type of cellular processes that require lots of energy and so would be sites of mitochondrial location, for example intracellular transport along microtubules.

--Mark Hill 09:54, 3 April 2009 (EST) Correct definitions for CAM terms, lots of science today uses acronyms (because the terms or gene names are very long), but what this can mean is that several acronyms can mean different things to different people.



Lecture 4 - The nucleus.

I found the nuclear lamins really interesting. They are only found in the nucleus and assemble and disassemble during mitosis/meiosis. The lamins are pegged around the nucleus and I think it is interesting how they contribute to the structure of the nucleus. A mutation can lead to the nucleus being folded with an unstable structure - Hutchinson-GUildford Progeria syndrome. [edit] Lecture 5 - Exocytosis.

exocytosis

I find exocytosis process simple to follow. The golgi apparatus however was a bit complex in understanding. The cisternae have no direct communication with each other and each cisternae contains different modification enzymes. The vesicles fuse at different layers of the golgi for modification. Where and for what reason they do this confused me.


The Mitochondria.

Mitochondria are the energy generators for cells. They create energy through a process called cellular respiration or oxidative phosphorylation. They have an important enzyme called ATPase which helps convert oxygen and nutrients into ATP. Apart from generating energy, the mitochondria can also synthesis proteins and replicate DNA. It is also important for storage of calcium ions. [edit] CAM types

Ancronyms

N-CAM: Neural Cell Adhesion Molecule

Ng-CAM: Neuron-glia Cell Adhesion Molecule

L-CAM: Liver Cell Adhesion Molecule

I-CAM: Intercellular Cell Adhesion Molecule [edit] Lecture 10

What is the name of the epidermal layer between the basal and granulosa layer and how does it relate to intermediate filaments?

The epidermal layer between the basal and granulosa layer is the stratum spinosum. the stratum spinosum has cuboidal cells that are joined together by desmosomes. These cells actively synthesize intermediate filaments called cytokeratins which are anchored to the desmosomes providing structural support to the skin.