--Mark Hill 14:39, 19 March 2009 (EST) Thank you for your feedback on the nucleus lecture. Did you know that chromosomes were inactive for gene expression when folded?
--Vincent Lee 01:14, 25 March 2009 (EST) Yes, I studied a bit of this in Mol. biol last semester. I believe the DNA strands have to separate and open up first so that information can be either read or copied, depending on what is required. But is this a quick process? And does the whole chromosome need to be unfolded?
--Mark Hill 07:49, 25 March 2009 (EST) Thank you for your feedback. I think you would be interested in reading about heterochromatin and euchromatin. Heterochromatin Is Highly Organized and Usually Resistant to Gene Expression This is not a molecular biology course, you do not need to know the details of transcription and its regulation, though we will touch on this again in signaling.
- Is this because the pathway is not yet fully known? Yes
- Also, you briefly mention the history and the years when it is discovered in all the lectures. It is mainly to get a background idea of when and how things were discovered.
--Vincent Lee 00:09, 2 April 2009 (EST) I just had a quick question regarding our h/w for mitochondria. The question was, what types of cellular processes require lots of energy from the mitochondria? What do you mean by 'lots of energy', is there a specified quantity or a limit? I have listed (on my homepage) some cellular processes... Are there any processes that would not be included in 'lots of energy'? Thnx,
--Mark Hill 10:24, 3 April 2009 (EST) Your list was more than sufficient, I just wanted you to identify cellular processes that consume energy and you will usually find a mitochondrion located nearby.
--Mark Hill 18:07, 6 April 2009 (EST) Your homework exercises are well organised!
--Vincent Lee 16:32, 10 April 2009 (EST) Just in regards to our individual project, how specific do we have to be in choosing our protein? On my page i have listed some proteins that I researched in re: Cell Cycle. Can my project be on one of the groups of proteins, e.g. CDKs, or should I choose an actual specific protein that belongs to that group? E.g. p16INK4a
--Vincent Lee 16:35, 10 April 2009 (EST) Also, is there a way of doing a word count in Wiki? Cheers,
--Mark Hill 00:54, 7 May 2009 (EST) Your individual project does need to be specific, remember I had asked for a single protein or technique. Some of the images are listed with you as the original author, yet they appear to be based on other sources. You should still acknowledge the original image you have used in preparing your figures. There is no easy way to do a word count, copy and paste the text into a word document if you really need to know.
Peer Review: Please add feedback here (21/05/09)
A) Overall, your project was the best among the projects I've read. It was easy to read and understand. And I couldn't hardly find the weak point of the project. I liked function as it is concise and clear. And diagram was placed in the right place so that what I was reading was related to the diagram next to it, except the 'simian virus'. I thought it could be related to the cause of the cancer, but couldn't find the direct relations from the topic. --Vincent Lee Thnx, the image of Simian virus is related to the first line in 'History'. As it is mentioned, p53 was first discovered as a protein in complex with T-antigen of simian virus 40.
B) really good logical flow. there isnt much you need to do to the actuall page layout. i think that if you related you info back to your diagrams it could link in better with the rest of you work. i also noticed you didnt have a glossary. also maybe a little more ifo on abnormalities woul have put the icing on the cake! (z3158969)
C) very well structured page, with good referencing, but perhaps a bit more referencing in the cell-cycle referencing is necessary. Also its a little lengthy so maybe look for some areas to cut down and refine information. Some more information on the specific relation of the structure to the function of p53 would be good too. overall very impressive thoough, well done! --Vincent Lee Thnx, the first part on 'cell cycle' is not actually part of the individual project. It was just something to provide a background... I have changed the title so it is a bit more clear.
D) This page was a very informative read. Your research was quite thorough and you managed to fit lots of info in your page. The diagrams really aided in the understanding of the text. Seems like p53 has much potential in the future!
E) I particularly liked the history timeline. Your work is well done. The images served great use, but what is that P53 meeting picture about? All the content was sufficient for me to understand the importance of this protein. --Vincent Lee Thnx, the p53 meeting logo is a symbol that represented the last p53 meeting in 2008. As mentioned, this conference provides scientist as well as general public and anyone interested in p53 to share their knowledge and discuss any information...
F) z3189168: I agree with the above comment. (I was going to move that comment down here but then I thought you would organise it by yourself). Your page just looks awesome. Looks like you put alot of efforts into it. It is very well written and so easy to read and understand. I really loved your images and diagrams as well.
G) I know it is passed the cut off time. But i must say what a great page. Really well presented and seems like you have put in a lot of work. Congrats.
- Peers I have reviewed:
3209709, 3217565, 3217578, 3219393, 3219606, 3191358, 2209471, 3160237, 3220823