Difference between revisions of "Talk:2015 Group 6 Project"

From CellBiology
Line 88: Line 88:
Bone and cartilage both contain COL2A1 gene which has a role in the production of type II collagen. Therefore, mutations in such a gene can show many abnormalities.
[[File:Radiograph of the Family Members.jpg|400px]]
Radiograph of the Family Members.<ref><pubmed>24949742</pubmed></ref>

Revision as of 18:05, 29 March 2015

2015 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

--Mark Hill (talk) 08:42, 21 May 2015 (EST) Your Group Project will now have peer feedback from the class, use this feedback to improve your project before submission.

Group Assessment Criteria

  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of cell biology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.

Group 6: Z5050795 | Z3333429 | Z3330686 | Z5016650

Hey, so I've just been looking around for a topic and maybe we could do something related to the fibres that make up the extracellular matrix e.g. collagen or elastin? I'm not sure though, what do you guys suggest? --Z5016650 (talk) 21:56, 22 March 2015 (EST)

Z3333429 (talk) 08:55, 23 March 2015 (EST) That sounds like a good idea. Will everyone be at the lecture tomorrow?

Z3333429 (talk) 09:13, 23 March 2015 (EST) My name is Emanuel btw. I had a look at the two lectures for EM and the main topics are:

EM Structure

  • Glycoproteins
  • Fibers
    • Collagen - has the most information, if we want to do this topic we have to lock it in ASAP.
    • Elastin
  • Hydrated Matrix
    • Proteoglycans
    • Carbohydrate
  • Adhesive
    • Fibronectin
    • Laminin

EM Function

  • Support for cells
  • Pattern of ECM regulates:
    • polarity
    • cell division
    • adhesion
    • motility
  • Development
    • migration
    • differentiation
    • growth factors

I think it is most likely that the topic will be broken up into structures but we may also be able to talk about the origin of EM and the function (although this may be a component of each structure that we have to discuss).

Okay let's lock in collagen then before someone else takes it.--Z5016650 (talk) 11:11, 23 March 2015 (EST)

Z3333429 (talk) 15:06, 23 March 2015 (EST) Okay I just emailed Dr Hill to let him know.

I would like to change the heading now, but no reply from the other two people! I guess we could just be safe and get it before its too late! --Z5016650 (talk) 19:53, 23 March 2015 (EST)

"Collagen Fibres" or "Collagen Component of the Extracellular Matrix" or something else? --Z5016650 (talk) 20:00, 23 March 2015 (EST)

--Z5016650 (talk) 20:38, 23 March 2015 (EST) Okay, i changed the heading! Feel free to add more words to it.

Z3333429 (talk) 00:47, 24 March 2015 (EST) I haven't heard back from Dr Hill yet. I won't be at the lecture tomorrow because I have a physio appointment so maybe ask him in the first 5 mins of the lecture just to make sure we have locked out topic in.

Z5016650 (talk) 18:37, 24 March 2015 (EST) To lock it in, we have to change the heading and we did that so it should be fine.

--Z3330686 (talk) 20:56, 24 March 2015 (EST)Hey guys! Sorry for the late response. Topic sounds good! I wasn't in the lecture today but will see you on thursday! My name is Emma.

--Z5050795 (talk) 17:28, 26 March 2015 (EST) Hi, guys! I`m late too.. Sorry about that. The topic sounds good! My name is Laura, I`m brazilian. I`m kind of lost in everything but i really want to work and contribute with the project. I just need to understand what is going on.. Please, don`t hesitate on saying to me what you think i should listen.. =)

--Z5050795 (talk) 10:33, 28 March 2015 (EST) Hi, guys! How are you?? I'm starting my research but before i want to confirm with you one thing. Our subtopic is Collagen Type B right?

--Z5016650 (talk) 14:09, 29 March 2015 (EST) Yeah Type II (2)

Function --Z5016650 (talk) 17:16, 29 March 2015 (EST)

Collagen Type II: Function

Article One:

This article suggests that the extracellular matrix of the cartilage is mainly composed of type II collagen. In healthy cartilage, type II collagen is not degraded. However, when it is degraded by enzymes this causes joint damage, this is what occurs in osteoarthritis.


Article Two:

In this article, it says collagen type II along with other proteins, has a role in skeletal development. Collagen II also interacts with minor collagens IX and XI to form heterotypic fibrils. Mutations in type II collagen in the extracellular matrix of the vertebrae show the important structural and developmental role of the fibrillar network.


Article Three:

In this article, it mentions that type II collagen is found in articular cartilage, which acts as a load bearing, low-friction, wear-resistant cushion. It is located at the ends of long bones to allow skeletal movement that is painless.


Article Four:

This article says that type II collagen plays an essential role in both fracture healing and long bone development. It is also mentioned that an increased production of type II collagen could enhance full bone formation. Type II collagen promotes bone marrow derived mesenchymal stem cell (BMSC) osteogenesis and inhibits adipogenesis. This means that collagen II may have a function in the early stage of BMSC differentiation.



Bone and cartilage both contain COL2A1 gene which has a role in the production of type II collagen. Therefore, mutations in such a gene can show many abnormalities.

Radiograph of the Family Members.jpg

Radiograph of the Family Members.[1]


  1. <pubmed>24949742</pubmed>