Difference between revisions of "Talk:2015 Group 3 Project"

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Overall, I think this page is coming together really well. There is still more research that needs to be done and you need to make sure you try keep a balance of visual and written media to keep the viewer engaged.
 
Overall, I think this page is coming together really well. There is still more research that needs to be done and you need to make sure you try keep a balance of visual and written media to keep the viewer engaged.
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'''Group 3 Peer Review'''
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This page is super easy to read. I love the clear use of sub-headings, which really make the different sections easy to read. Especially for the clinical significance section, it's easy to look at the different ways molecular defects can correlate to medical conditions. Perhaps more detail on how elastin brings about the clincal problems of the disease is needed. The diagrams are simple and well used, and don't require too much deciphering - often times, diagrams for these sorts of complex molecular processes are super complicated and require a significant level of pre-requisite knowledge to interpret (e.g. knowledge of certain mediators, enzymes etc.). There is a fine balance between not being too simplistic and not being over complicated with regards to the diagrams.

Revision as of 16:52, 20 May 2015

2015 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

--Mark Hill (talk) 08:42, 21 May 2015 (EST) Your Group Project will now have peer feedback from the class, use this feedback to improve your project before submission.


Group Assessment Criteria

  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of cell biology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.

Group 3: Z3463637 | Z3374116 | Z3332339 | Z5050826

Hey there guys, there are some interesting subtopics that we can discuss under the topic 'Extracellular Matrix'. Theres quite a bit of information on the different fibre types in the ECM as well as the mechanical properties of ECM. I think we should do a bit of simple research first and find which one we can find the most easily accessible information as well as which one seems more interesting to you guys. --Z3374116 (talk) 23:03, 22 March 2015 (EST)

--Z3463637 (talk) 11:21, 23 March 2015 (EST) Collagen would be a pretty easy topic to do! Theres quite a bit of information about this. I can see another group after this as well though... we should decide soon.

--Z3463637 (talk) 21:45, 23 March 2015 (EST)-- Well, collagen has been taken now so... Elastin? Seems like the next best option. We need to decide asap before all the good ones get taken. Please reply!!!!!

--Z3374116 (talk) 01:03, 24 March 2015 (EST) Elastin seems nice and simple!!

--Z3463637 (talk) 08:48, 24 March 2015 (EST) Elastin it is! I changed the heading for our page, before another group takes it. We can always change it if the other 2 members disagree.

--Z3332339 (talk) 09:18, 25 March 2015 (EST) Hey guys I think Elastin is a great topic to do! I think there is lots of info on it as well

--Z3463637 (talk) 18:01, 26 March 2015 (EST) IDEAS FOR SUBHEADINGS:

- Introduction

- History

- Structure - z3463637

- Function - z3332339

- Assembly -z3374116

- Clinical Significance [Does this cover the mutations?] - z5050826


Here are the subheadings we have so far, feel free to add more to this list and pick one to research.

--Z3463637 (talk) 21:00, 27 March 2015 (EST) Yes, clinical significance will include abnormalities/diseases associated with elastin.


Lab 3

In silico analysis suggests interaction between Ebola virus and the extracellular matrix. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333865/ <pubmed>PMC4333865</pubmed>

Matrix metalloproteinases in destructive lung disease. http://www.sciencedirect.com/science/article/pii/S0945053X15000396

Thrombosis, like other cardiovascular diseases, has a strong genetic component, with largely unknown determinants. EMILIN2, Elastin Microfibril Interface Located Protein2, was identified as a candidate gene for thrombosis in mouse and human quantitative trait loci studies. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319747/ <pubmed>PMC4319747</pubmed>

Vitamin a deficiency and alterations in the extracellular matrix. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245576/ <pubmed>PMC4245576</pubmed>

--z3374116 (talk) 15:28, 20 April 2015 (EST)

ASSEMBLY OF ELASTIN FIBRES

Article 1

Research article breaks down the main components of Elastin describing its characteristics. Observations on the alternating hydrophobic and cross-linking characteristics within Elastin are described. Focuses on explaining in depth the basis of self-organizational ability of elastin-based polypeptides and how the information from them can possibly assist in developing self-assembling biomaterials.

<pubmed>11911775</pubmed>

Article 2


<pubmed>25811498</pubmed>

Article 3

This article focuses on investigating the mechanisms behind the elastic fiber assembly via observing the molecular interactions between 'elastin' and 'microfibrillar' components using solid-phase binding assays. Observations found that the major cross-linking region in elastin is formed by association of domains encoded by exons 10.19 and 25 of tropoelastin.

<pubmed>8575256</pubmed>

Article 4

<pubmed>1648323</pubmed>

Article 5

<pubmed>18228265</pubmed>

--Z3463637 (talk) 11:18, 2 April 2015 (EST)

Article 1

The study highlights the role of recently identified glycoproteins on or surrounding elastic fibers of tissues and organs. Short fibulins, particularly -3, -4 and -5 have very potent elastogenic activities. The activities of these short fibulins were observed in knockout mice and it was found that they play an integral role in the formation of elastic fibers. This review article is relevant to the formation and structure of elastin.

<pubmed>PMC2880191</pubmed>

Article 2

Before manufacturing biomaterials, the biopolymer materials must be assessed based on their functionality and design parameters. The review article discusses the different biopolymer materials, including elastin, highlighting its structure and functional properties. It is found that a integrated design approach using experimental and computational modeling procedures are required to study these materials.

<pubmed>22938765</pubmed>

Article 3

Elastin is necessary for the elasticity and recoiling properties that are evident in blood vessels. In a study of elastin knockout mice, it was revealed that elastin also plays a role in arterial morphogenesis. This review article is relevant to the sub-topic as it highlights the functions and structure of elastin.

<pubmed>24679588</pubmed>

Article 4

Previous studies have shown that developing arteries and neural crest EGF-like (DANCE) proteins are essential for the formation of elastin. The identification of latent transforming growth factor-β-binding protein 2 (LTBP-2), was found to promote the deposition of DANCE proteins onto fibrillin-1 microfibrils. This ultimately induces the formation of elastin.

<pubmed>17581631</pubmed>

--Z3332339 (talk) 22:49, 26 April 2015 (EST)

Lab 3 Assessment


Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves [1]

Elastin is commonly found in the arteries due to the high pressure of blood coming from the heart, and its function to supply oxygenated blood to all organs, its elasticity is important due to enormous pressure it needs to withstand. Pulmonary arterial hypertension (PAH) causes stiffness in these arteries affecting the ability for these arteries to stretch and maintain a relatively constant pressure with high blood flow. This article looks at the structure and function of this relationship in PAH and the mechanobiological adaptations that are undergone by elastic arteries in response to PAH.


Comparison between human fetal and adult skin [2]

Elastin is important in adults for restoring backing the normal tissue architecture example pinching of skin. According to this research, extracellular components such as elastin are important in the scarless healing process that takes places in on early fetal gestation. The role that elastin or another name, tropoelastin is investigated. Elastin is not found in fetal skin up till week 22. Although it is not a primary extracellular component for scarless healing in fetal wounds, it is still plays a role in skin regeneration. A comparison between fetal skin and adult skin is looked at.


Spatial Distribution and Mechanical Function of Elastin in Resistance Arteries A Role in Bearing Longitudinal Stress [3]

Arteries within the human consists of three layers and are most evident closest to the heart due to the properties that make them withhold the enormous pressure the heart pumps. The walls of the arteries exist in three layers where the outermost layer, called the tunica adventitia providing tensile strength, the hypothesis this research grouped investigated was whether the elastin fibres are subject to longitudinal stretch.


Tropoelastin - a versatile, bioactive assembly module [4]

The monomer for elastin is tropoelastin. Thus when many Tropoelastin molecules are bonded together (covalent bonds )with cross links such as lysal oxidase [5] they bind together to form the protein elastin. There is only one gene for that codes for tropoelastin and thus only one protein. The research stems on the facts that tropoelastin is compatible with synthetic and natural co-polymers. As a result of this, it enables these researches to expand upon the applications of its potential use in next-generation tailored bioactive materials such as when responding to injury. this is because large quantities of the monomer have only become accessible recently. Isolation of tropoelastin was previously intricate and inefficient due to its rate of cross linking incorporated into growing the elastic fiber in the living. However by synthesizing the elastin gene, this has allowed for a recombinant tropoelastin that is identical to the naturally secreted human form giving that compatibility that allows scientist and research to work with in a versatile way.


Insights into the role of elastin in vocal fold health and disease [6]

Elastin can be defined as a an extracellular matrix protein that is responsible for tissue elastic recoil. Therefore, because of its function it can then be assumed that it is found in different parts of the human body that require tissue recoiling. For example, lungs(30%)- expansion when inhaling and exhaling air, large arteries (70%)-to be able to recoil back to their shape consistently as blood is bumped through them, skin (2-4%)- to be able to withstand stretches and sustain its original shape. Elastin can also be found in the vocal fold of the lamina propria, making up 9% of the total protein. Thus, the lamina propria experiences greater amounts of mechanical strain relative to skin but less when compared to lungs and arteries.


--Z3463637 (talk) 20:35, 11 April 2015 (EST) I will also be talking about distribution in the "structure" subheading.

--Z3463637 (talk) 00:26, 23 April 2015 (EST) I've started working on the introduction, and i'll include the distribution here instead. Feel free to change or add anything to the introduction! How is everyone going with their sections? Also, I haven't found much about the history of elastin in my research - maybe we can exclude or replace this heading if we can't find much information.

--Z3374116 (talk) 15:46, 23 April 2015 (EST) Ill try help search for historical info as well (I think it might be good to even have a little bit of historical information). We could add more subheadings as seem fit provided we can finish our sections :p. Been searching for my part finding some good stuff, just need to slowly paste stuff into our wikipage. The weather and blackouts havent helped much. Lets slowly get things rolling.

Thanks for adding the intro

--Z3374116 (talk) 18:07, 23 April 2015 (EST) Mark said that because we have such a specialized structure, we need to know everything about all things related.Interactions, genome etc.

Pubmed Protein Database / Pubmed Genome Database


--Z3332339 (talk) 22:55, 26 April 2015 (EST) Ok i had my section on just the wiki page but not here on discussion but i just pasted it here as well just in case because i reread the assessment item and it said discussion page. Thanks for adding the intro :) I remember him saying those things too and i remember him saying include any isoforms of it, I also remember him mentioning the word Mendelian ..but im not sure what he means by this.. do you guys recall?


--Z3332339 (talk) 17:54, 30 April 2015 (EST) Hey guys so from todays feedback from Mark we need to look at

-expression

-how its made

-gene that codes for it

-knock out mouse database

-fibre (aus one)/fiber- and write this in intro

-degradation

-turn over of elastin--arteries, get stiff

-distribution-tunica intima and tunica externa

-components of elastic fiber

-interaction

-organs

-histological images


--Z3463637 (talk) 13:04, 3 May 2015 (EST) I moved the component's subheadings under structure.

Heres the intro you wrote under components z3374116 - I think it should go under the "Assembly" heading. I understand how closely related these two sections are, but i will try to talk about the interactions of the componenets only very briefly, without talking about assembly too much.

The formation of Elastic fibers is a complex process which is comprised of multiple interactions between different proteins, enyzmes and binding sites. Elastic fibers are mostly comprised of Elastin and Micro-fibrils which consist make up most of the structure, the processes of formation are closely regulated and carried out by the smaller protein components; Tropoelastin, Lysyl Oxidases (LOX), Fibrilin-4 / Fibrilin-5 and Integrins


--Z3332339 (talk) 09:39, 4 May 2015 (EST)

He also said Histological diagrams, so i added it to the list :)... he also said he could give us some too :P

--Z3374116 (talk) 16:11, 4 May 2015 (EST) Mark also told us to include hand drawn diagrams it to our project, Im currently drawing mine out (assembly steps). Lets try sort all this out by this week Thursday because peer assesments are coming up!

--Z3463637 (talk) 22:23, 4 May 2015 (EST) I will most likely be drawing a picture of elastic fibre - there aren't many decent pictures out there. I deleted the "history" heading, because of the upcoming peer assessment. We can put it back up if we find information on it, but if not we won't have a "history" subheading.

The page doesn't have to be completely done for peer review right....?

--Z3374116 (talk) 00:01, 7 May 2015 (EST) The page doesnt have to be complete for peer assessment, but having it done would be best i guess haha. Making my assembly part more formal and informational

--Z3374116 (talk) 17:57, 7 May 2015 (EST) http://cdn.intechopen.com/pdfs-wm/19028.pdf [Elastin Based Constructs]

  1. <pubmed>PMC2593497</pubmed>
  2. <pubmed>PMC2799629</pubmed>
  3. <pubmed>PMC3380608</pubmed>
  4. <pubmed>PMC3879170</pubmed>
  5. <pubmed>PMC3190022</pubmed>
  6. <pubmed>PMC3190022</pubmed>

Group 3 peer review

Good, short and concise introduction to the topic. You briefly touch on a bit of the history of elastin in the tropoelastin and elastin section (about the study of it being hindered), potentially this could be moved so its after the intro section, with a bit more detail on the history of it? Alongside the text describing the structure it may be useful to have some diagrams of it so people can visualise it next to the description. Really like the way you’ve put the key words in bold, really makes them stand out! The section about the assembly of elastic fibre is really good, really good hand drawn image and other diagram obtained is clear and informative. Good use of number bullet points to split up the text and explain the process. I don’t think much would need changing in this section, except some of the words i.e. Lysyl Oxidases have already been abbreviated (LOX) in the previous section, so don’t think it’s necessary to do it again. The function section seems a bit disorganised because a brief intro to the function is given which refers to a diagram further down the page and then following this is a random bit on tropoelastin, so I think this section should be moved to somewhere more appropriate or use a different heading. Also, instead of using the paper titles as the subheadings I think these should be summarised into a shorter title. Good use of diagrams in this section, maybe if they were made square to the text it’d look a bit neater. The clinical significance section is very informative, lots of information which is good and I like that a range of conditions have been used – nice and topical using ebola virus. The only thing for this section to improve on would be the addition of videos/images to split up the text.


Group 3 peer review

The page is looking good. The introduction is very well written and appropriately summarizes the whole page. However, I noticed that you don’t have a history/timeline/current/future research section. It might be good to include those sections briefly at the beginning as it would make the page more interesting and provide context for your reader.

In the structure and components section, it might be beneficial to include a diagram of the molecular structure of elastic fibers or possibly draw something so the reader can relate what you’re describing in the text to a visual diagram. I thought the diagrams you used in displaying elastic fiber assembly were very effective but that section might be better if the process was more simplified in text form as well.

It would be great to have visual representations of the diseases such as Ebola in the clinical significance section as it would make it more interesting. It might also be better to simplify some of that information as there seems to be a lot of text. The functions section is good but it might be more effective if you added a subtopics into that section dividing it into different parts e.g. heart, skin.

Overall, I think the page is coming together well.

Group 3 peer review

Your webpage has many positive aspects to it. I thought the organization of the material on the page was great. You also made the material easily understood for readers without prior knowledge of the subject. I thought the rubber band analogy was a good idea to include in your webpage as it gave a good mental picture for the reader, making the subject relatable. It was evident that thorough research of the subject matter was conducted.

To make your webpage better, I would suggest going through and re-reading for grammatical errors as there were some run-on sentences as well as issues with sentence structure. There were some points where phrases were re-used multiple times within a few sentences. For example, 'of elastin' became repetitive within the Tropomyosin and Elastin section.

I appreciated the hand drawn image you created. It seemed very informative. However, the words in the key along with the labels were not legible. With correction of this issue, the image would be fantastic to incorporate. I thought you included a good ratio of photos to text within your webpage. There were photos in the Heart and Lungs sections that needed legends. Otherwise, I thought your project was well-written and consistent in information depth throughout.


Group 3 Project Review In terms of content, I’m very pleased with the page. It’s not overly long (but could do with some trimming down), but all the relevant and expected information is present. There’s a little too much text, so I’d recommend replacing some of your larger concepts with a picture equivalent. For example, much of the discussion on microfibrils could be discussed with a diagram. The Clinical Significance subheading also desperately needs a picture or two. I understand that it’s probably difficult to track down a picture on the role of elastic fibres in Ebola or thrombosis, so you may have to draw it.

The biggest problem here is with readability. I really had to force myself through this because, while it was interesting, it was fairly difficult to interpret. There are widespread grammatical abnormalities that need to be addressed. These are especially prevalent in the Introduction and Structure and Components sections, but do infiltrate other sections as well. I strongly recommend you go over each other’s sections with a fine-toothed comb to try and get all the grammatical errors out, because it really affects the readability of your page.

Also, small thing: get rid of Dr Hill’s “please have something ready for the next lab” notice. You also have some empty references (23-25) – that’s probably due to an easily fixed bug in your code.

Overall, I think the wiki page is very good in terms of content, but needs some work as far as presentation goes. The only real changes that need to be made to the content is addition of more pictures and the corresponding excision of unnecessary details. Most of your focus now, however, should go into making your page as easy-to-read as possible.

Group 3

Group 2 is doing their project page on Elastic Fibres. The first thing that needs to be developed is the introduction, but it is understandable that you need the rest of the information to be finished before you can summarise it simply in the introduction. There is good use of illustrations and pictures to summarise the information accompanying it, but as I scrolled down I got confused when the information transitioned suddenly to examples in the heart, lung and skin. It would be good if there is a separate heading to clearly mark out the examples regarding how elastic fibres function in common tissues where they exist. The images in that section also need to be referenced, may have to ask Mark how to do it if you got it from virtual slides (it looks like those images). There are some uncompleted parts here but thats fine as well, as long as they are finished soon. In the diseases section, are there any pathways related in the diseases that involve other molecules that interact with the elastin? Do these diseases illustrate the role of these elastin fibres in the extracellular matrix? You may want to make sure that references section is actually a new section, I have a feeling that the coding is wrong. Overall I think this is a project in development, but the elements are all there, just need to be developed a little :D good job!

Group 3 Peer Review

Overall, I think your page is coming together really well and on the border of completion!

Key points clearly described: I felt that the key points were clearly described, and didn’t feel that I had any difficulty in understanding any of the components. However, I think your page does need a bit more information. For example, under ‘Skin’, when you mention that the skin is composed of five layers, I think you should address/ list these five layers (however I do see an article there, so I’m assuming this is a work in progress). The same goes for ‘Spatial Distribution and Mechanical Function of Elastin in Resistance Arteries’, where you mention ‘three layers’. They are labelled in the image, but I think you should address them in the text as well. Just a note, I really liked your analogy to the rubber band! I thought it worked well!

Understanding? Content, headings, sub – headings, diagrams, tables, graphs? Teaching at peer level? Own innovative diagrams, tables or figures, Interesting examples or explanations?: The images used were good and relevant to what was being described. I do think that you need to include a lot more images though, particularly in the function and clinical significance section to break up the text. I really liked the ‘Process of Elastic Fibre Assembly’ image that you created. It’s really well done! However, I noticed in the text that you describe the steps in the image from 1 -5. This is not obvious or very clear. Maybe you should either centre the image and have the steps following or include the steps in the image description. Also, under the ‘Spatial Distribution…’ heading, the images you have are really good, but the one on the right I feel needs to either be referred to in the text or described in a text box, because it is not clear what the image is showing. Overall, in terms of images, spread them out so they are not clumped together, or even on the same side of the page consistently.

Content correctly cited and referenced: Everything appears to be referenced well. Don’t forget to remove the reference link under Skin!

Evidence of significant research / Adequate research: It appears you have done a great deal of research, and your concepts are clearly well – covered. Just fill in the little gaps I mentioned (layers of skin and three layers), and find supporting articles for areas where only minimal references have been made. The more articles you look at and derive information from, the better and more credible your page will sound.

Other: There is quite a few grammatical errors. Just fix that up. And on another note, under the ‘Tropoelastin and Elastin’ title, if you talk about elastin first, I think it is more logical that the heading has elastin first.


Group 3 Peer Review

The project is amazing, guys, really!! The content is very rich, the text is clear. The images shown are good and helps a lot in the understanding of the content.

I cannot say that I found problems in what you guys have written… The only I can say is that a section with history would be an interest thing to add on the page. Furthermore, the section about clinical diseases could have more images, because the great amount of text makes the reading tiring. However, if the reader finds enough energy to go through this section, he or she will have plenty of information about the diseases involved with the elastic fibres. A section about current and future researches would also be great. Despite these little problems, the page is very good, I would give you high marks if I could! Congratulations, keep on!


group 3 peer review

Group 3, overall you guys have made a pretty good and solid work. The structure, headings and subheadings are well explained, I just think there could be somethings about the history of some of the elastic fibres, as well as current research and treatment can be contemplated. The drawing was so far the best I have seen among the groups and the other images are very elucidative, I just think you could add something extra to the clinical significance to give a break on the reading as there is a lot of information. Furthermore, I think you could have some more extra references; that would enrich your work even more. Apart from that the rest is looking really good. Nice job!


Group 3: Pros: It is evident you guys have done a lot of research for your topic and the pictures helpful in understanding the topic you guys are exploring. You have utilised your own innovative diagrams.There is an adequate amount of information in each section. The content is referenced Cons/improvements: You guys could improve by using more subheadings. There is no history/current research section. The histology pictures could be better positioned to maintain a flow in the page


Group 3 Peer Review

The page is very good. The introduction is clearly and briefly and it gives a good idea about Elastic Fibres. The structure and components section is clearly, but I think a image would help to understand. Finally, I noticed that you did not put something about history and future researches that would be good in the beginning of the page.

The “Assembly of Elastic fibre” is good too, and I really like the draw about the process of elastic fibre assembly. The other image (Role of MFAP-4 in Elastic fiber assembly) was well-chosen too. Finally, I like the step-by-step that you made in the final of section, because it summarizes the process being very informative and the reader can see the images at the same time. However, the images should be referenced correctly.

The functions related with organs, like heart, lungs and skin was a great idea. Also, the clinical significance you chose relevant diseases to relate but I think you could explain more deeply how the elastic fibres are related with this diseases. Also, I think some images in this section would be good to break up the text and the reader would feel stimulated to read at all.

Overall, the page is very clearly and informative so far. I think there are few little problems such as images referencing but I am sure that the page is still in progress and you will fix it. Also, it would be more informative if you include more images.

Peer review

The introduction is well written as it is accurate and concise. You have briefly mentioned the discovery/history of elastin in the structure and components subheading. You may want to create a section devoted to history as it is always nice to know how we know the things we do today. Mark also seems to love history :).

The structure section is well done, I especially like how you talked about the synthesis of an elastic fibre. The hand drawn diagram is also very good as it is colourful which captures the viewers eye but is also very informative (it makes my drawing look bad)

The function section has been done really well, providing the reader with easy to understand information. However the two images in this section have no caption. How is the viewer suppose to draw information from this if they don’t know what it is? On a whole, I think the page needs more visual material such as pictures or videos such as something to support the rubber band analogy. Have a video showing an elastic band stretching and returning to its original size? That’s just a suggestion it is already pretty well explained.

From the looks of things the referencing has been done correctly, there are no duplicates in the reference list from what I can see. However, there are a few empty slots which Im guessing they are not pubmed articles. You need to manually put them in which is a pain but easily fixed :). The images look correctly referenced from what I can tell, containing the appropriate copyright information.

Overall, I think this page is coming together really well. There is still more research that needs to be done and you need to make sure you try keep a balance of visual and written media to keep the viewer engaged.

Group 3 Peer Review This page is super easy to read. I love the clear use of sub-headings, which really make the different sections easy to read. Especially for the clinical significance section, it's easy to look at the different ways molecular defects can correlate to medical conditions. Perhaps more detail on how elastin brings about the clincal problems of the disease is needed. The diagrams are simple and well used, and don't require too much deciphering - often times, diagrams for these sorts of complex molecular processes are super complicated and require a significant level of pre-requisite knowledge to interpret (e.g. knowledge of certain mediators, enzymes etc.). There is a fine balance between not being too simplistic and not being over complicated with regards to the diagrams.