Difference between revisions of "Talk:2015 Group 3 Project"

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==--[[User:z3374116|z3374116]] ([[User talk:z3374116|talk]]) 15:28, 20 April 2015 (EST)==
 
==--[[User:z3374116|z3374116]] ([[User talk:z3374116|talk]]) 15:28, 20 April 2015 (EST)==
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'''ASSEMBLY OF ELASTIN FIBRES'''
  
 
'''Article 1'''
 
'''Article 1'''

Revision as of 15:43, 23 April 2015

2015 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

--Mark Hill (talk) 08:42, 21 May 2015 (EST) Your Group Project will now have peer feedback from the class, use this feedback to improve your project before submission.


Group Assessment Criteria

  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of cell biology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.

Group 3: Z3463637 | Z3374116 | Z3332339 | Z5050826

Hey there guys, there are some interesting subtopics that we can discuss under the topic 'Extracellular Matrix'. Theres quite a bit of information on the different fibre types in the ECM as well as the mechanical properties of ECM. I think we should do a bit of simple research first and find which one we can find the most easily accessible information as well as which one seems more interesting to you guys. --Z3374116 (talk) 23:03, 22 March 2015 (EST)

--Z3463637 (talk) 11:21, 23 March 2015 (EST) Collagen would be a pretty easy topic to do! Theres quite a bit of information about this. I can see another group after this as well though... we should decide soon.

--Z3463637 (talk) 21:45, 23 March 2015 (EST)-- Well, collagen has been taken now so... Elastin? Seems like the next best option. We need to decide asap before all the good ones get taken. Please reply!!!!!

--Z3374116 (talk) 01:03, 24 March 2015 (EST) Elastin seems nice and simple!!

--Z3463637 (talk) 08:48, 24 March 2015 (EST) Elastin it is! I changed the heading for our page, before another group takes it. We can always change it if the other 2 members disagree.

--Z3332339 (talk) 09:18, 25 March 2015 (EST) Hey guys I think Elastin is a great topic to do! I think there is lots of info on it as well

--Z3463637 (talk) 18:01, 26 March 2015 (EST) IDEAS FOR SUBHEADINGS:

- Introduction

- History

- Structure - z3463637

- Function - z3332339

- Assembly -z3374116

- Clinical Significance [Does this cover the mutations?] - z5050826


Here are the subheadings we have so far, feel free to add more to this list and pick one to research.

--Z3463637 (talk) 21:00, 27 March 2015 (EST) Yes, clinical significance will include abnormalities/diseases associated with elastin.


Lab 3

In silico analysis suggests interaction between Ebola virus and the extracellular matrix. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333865/ <pubmed>PMC4333865</pubmed>

Matrix metalloproteinases in destructive lung disease. http://www.sciencedirect.com/science/article/pii/S0945053X15000396

Thrombosis, like other cardiovascular diseases, has a strong genetic component, with largely unknown determinants. EMILIN2, Elastin Microfibril Interface Located Protein2, was identified as a candidate gene for thrombosis in mouse and human quantitative trait loci studies. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319747/ <pubmed>PMC4319747</pubmed>

Vitamin a deficiency and alterations in the extracellular matrix. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245576/ <pubmed>PMC4245576</pubmed>

--z3374116 (talk) 15:28, 20 April 2015 (EST)

ASSEMBLY OF ELASTIN FIBRES

Article 1


<pubmed>11911775</pubmed>

Article 2


<pubmed>25811498</pubmed>

Article 3

This article focuses on investigating the mechanisms behind the elastic fiber assembly via observing the molecular interactions between 'elastin' and 'microfibrillar' components using solid-phase binding assays. Observations found that the major cross-linking region in elastin is formed by association of domains encoded by exons 10.19 and 25 of tropoelastin.

<pubmed>8575256</pubmed>

--Z3463637 (talk) 11:18, 2 April 2015 (EST)

Article 1

The study highlights the role of recently identified glycoproteins on or surrounding elastic fibers of tissues and organs. Short fibulins, particularly -3, -4 and -5 have very potent elastogenic activities. The activities of these short fibulins were observed in knockout mice and it was found that they play an integral role in the formation of elastic fibers. This review article is relevant to the formation and structure of elastin.

<pubmed>PMC2880191</pubmed>

Article 2

Before manufacturing biomaterials, the biopolymer materials must be assessed based on their functionality and design parameters. The review article discusses the different biopolymer materials, including elastin, highlighting its structure and functional properties. It is found that a integrated design approach using experimental and computational modeling procedures are required to study these materials.

<pubmed>22938765</pubmed>

Article 3

Elastin is necessary for the elasticity and recoiling properties that are evident in blood vessels. In a study of elastin knockout mice, it was revealed that elastin also plays a role in arterial morphogenesis. This review article is relevant to the sub-topic as it highlights the functions and structure of elastin.

<pubmed>24679588</pubmed>

Article 4

Previous studies have shown that developing arteries and neural crest EGF-like (DANCE) proteins are essential for the formation of elastin. The identification of latent transforming growth factor-β-binding protein 2 (LTBP-2), was found to promote the deposition of DANCE proteins onto fibrillin-1 microfibrils. This ultimately induces the formation of elastin.

<pubmed>17581631</pubmed>


--Z3463637 (talk) 20:35, 11 April 2015 (EST) I will also be talking about distribution in the "structure" subheading.

--Z3463637 (talk) 00:26, 23 April 2015 (EST) I've started working on the introduction, and i'll include the distribution here instead. Feel free to change or add anything to the introduction! How is everyone going with their sections? Also, I haven't found much about the history of elastin in my research - maybe we can exclude or replace this heading if we can't find much information.