Talk:2013 Group 6 Project

From CellBiology
Revision as of 17:57, 11 April 2013 by Z3375878 (talk | contribs)

2013 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

  1. Do not remove this notice {{2013 Project discussion}} from the top of the discussion page.
  2. Newest student comments should be entered at the top of this current page under the subheading "Student Discussion Area" (you cannot edit the sub-heading title).
  3. All comments should begin with your own signature button, that will automatically enter student number date/time stamp.
  4. Do not use your full name here in discussion, if absolutely necessary you may use first names only.
  5. Do not remove or edit other student comments.
  6. Use sub-headings if you want to add other draft information, images, references, etc.
  7. Only your own group members should edit this page, unless directed otherwise by the course co-ordinator.

Group Assessment Criteria

  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of cell biology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.

Week 2 Project topic selection, preliminary researching on the topic.

Week 3 By the next practical class (after the mid-session break) there should be sub-headings and content on your actual project page and interactions between individual group members on this discussion page.

Week 4 Each group member should now have selected 4 papers relevant to their section of the project. These, or any other papers, can now be used to generate content (text, images and tables) within the project page. Students can also work on additional sub-headings on the project page.

Week 8 Peer assessment of group project work.

  • Each student will carry out an assessment of all Group projects other than their own.
  • This written assessment should then be pasted on the actual project discussion page and your own individual student page.
  • The peer assessment for each project should be concise and include both positive and negative critical analysis of the current project status.
  • The actual assessment criteria (shown above) can be used if you like.
  • Each student assessment should be your own work and be completed before the next Lab.

Article 1, Identifies subtle differences between different species mitotic processes Anaphase-promoting complex/cyclosome (APC/C) triggers chromosome isolation along with mitotic exit through selective targeting of cell cycle regulators. Yeast complementation studies composed the nucleus of the investigation however there was no positive result yielded subtlety highlighting servere differences between the 2 different species APC/C’s at review. Further questions have been raised by the negative result whether the parasite used T. brucei even holds MCC-APC/C complex counterpart, this prompted the next part of research comparing the protein characteristics of APC1 fusion proteins at different stages of the cell cycle, the abundant of unchanged proteins indicates that T. brucei has its very own APC/C.[3]

Article 2, Identifies APC role in initiating Anaphase Metaphase-to-anaphase transition is tightly controlled by anaphase-promoting complex (APC) motions. APC promotes the degradation of several proteins that inhibit anaphase, It has been shown that with out destruction of these protein inhibitors the transition is static. [4]

Article 3, Role of regulatory proteins in coordination of Metaphase to anaphase transition The regulatory protein Cdc20 triggers APC/C at the start of the metaphase-anaphase transition. Cdh1 a membrane protein which is able to control the fate of certain cells, triggers anaphase through the G1 stage of the cell cycle. APC/C specifically targets securin(anaphase inhibitor), Early destruction of this inhibitor is coordinated by nuclear transport factors(Nup98 and Rae1), This mechanism is strictly governed to guarantee appropriate timing of degradation. [5]

Article 4, Proves a way to by pass regular cellular requirements by chemical means Kinetochore coordinates chromosome segregation through a binding relationship with microtubules. Sufficient kinetochore-microtubule attachments must be present at the spindle assembly checkpoint however cells can override this regulation through mitotic slippage. Through experimentation It was found when using the anti neoplastic agent nocodazole along with cellular interaction of Cdh1 miotic slippage was achievable. This highlight the critical role of inhibition through destruction in mitotic processes. It must be noted that this experiment could be an insight into a possible future tumour treatment.

FAK-Focal Adhesion Kinase Antibody is by antibody

--Mark Hill (talk) 10:17, 4 April 2013 (EST) OK guys some action here, we need 4 papers from each of you before the Prac next week and the actual Project page still lacks sub-headings.

- Instead of doing the history, I'll leave that for later and start on the introduction because it might tie the topic in all together and new sub-topics might come up which may be worthy of mention/their own sub-heading. I know we said we'd do this later but it might keep us on track and direct us. --Z3375878 (talk) 16:57, 11 April 2013 (EST)

- Anyone have any ideas on sub-headings? Also are we going to just be talking about Anaphase in humans or can we say use examples of defects from other creatures? --Z3375878 (talk) 07:12, 7 April 2013 (EST)

- I found 2 about the spindle, I'll keep looking for articles about the defects however I haven't yet found anything about the history, anyone had any luck?--Z3375878 (talk) 10:12, 3 April 2013 (EST)

- For this week's lab assessment I'll do the defects--Z3375878 (talk) 09:45, 3 April 2013 (EST)

- I'll do the spindle fibers topic for the next lab assessment--Z3371084 (talk) 16:27, 28 March 2013 (EST)

- I'll do the history topic --Z3375878 (talk) 16:25, 28 March 2013 (EST)

- Point to remember about when we start referencing our text later: DO NOT cite reviews, e.g. don't cite the review if the review mentions the result of the study its reviewing. Cite the ORIGINAL PAPER that actually found the result.

Don't use too much information from textbooks - find stuff out directly from research papers and articles, and get most info/images from these sources. Allowed ONE really good image from Wikipedia.

Start with reviews then move onto research papers.

I suggest we just choose a random topic that we will each cover for the sake of speeding up research progress and for the next lab assessment - we could then change topic if we don't like it --Z3375878 (talk) 16:22, 28 March 2013 (EST)

- Hi guys, I've started to create the page - I think it should be split up with intro, history, then a relatively large section on the whole process (I've put some points down as to how we should perhaps separate it), defects resulting from anaphase, and finally current research. If you guys have any suggestions, please post them here.

Currently I think we should continue to find any research articles in regards to anaphase and perhaps post up some summaries in the appropriate section - then once more information has come through we can decide on who does what task! Thanks! --Z3292017 (talk) 15:51, 28 March 2013 (EST)

- So how are we going to approach this first, just find articles and journals etc. until we get a good idea of what it's all about and maybe we can then do some planning? --Z3375878 (talk) 15:50, 28 March 2013 (EST)

Here are some syndromes related to nondisjunction (fail to separate properly): Down syndrome, Patau syndrome, Edward's syndrome, Klinefelter syndrome, Turner's syndrome--Z3371084 (talk) 17:35, 26 March 2013 (EST)

Articles about Anaphase (Meiosis)--Z3371084 (talk) 17:36, 26 March 2013 (EST) [1] [2] [3] [4]


- This is our first comment --Z3292017 (talk) 17:01, 21 March 2013 (EST)