Talk:2012 Group 5 Project

From CellBiology

--Mark Hill 11:46, 4 April 2012 (EST) As of Wed 4th April (week 5) other than the requested individual assessment references there is nothing on your project page (except the template sub-headings) or discussion page (other than allocation of work) that indicates that you are carrying out the research work on your project . I remind you of the assessment criteria and my expectation of ongoing demonstrable contributions.

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.

Group 5's Discussion Board

Hey guys, I found four articles relating to abnormal function of the pathway:

Paper 1

Taketo, M Mark. "Shutting down Wnt signal-activated cancer." Nature Genetics 36. (2004): 320-22. DOI: 10.1038/ng0404-320

In this article, New evidence suggests that Wnt signaling can be suppressed or further activated by upstream signals, even though the pathway seems to be constitutively activated by downstream mutations in cancer cells.

Paper 2

Macdonald, Bryan. "Wnt/β-catenin Signaling: Components, Mechanisms, and Diseases." Developmental Cell 17.1 (2009): 9-26. PMID: 19619488

This article highlights some key aspects of Wnt/β-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis, and discuss potential therapeutic implications

Paper 3

Luu, Hue. "Wnt/β-catenin Signaling Pathway as Novel Cancer Drug Targets." Current Cancer Drug Targets 4. (2004): 653-71. Doi: 1568-0096/04

This review discusses some of the strategies that are being used or can be explored to target key components of the Wnt/β-catenin signaling pathway in rational cancer drug discover.

Paper 4

Giles, R., Johan, H., Clevers, H. “Cought up in a Wnt storm: Wnt signalling in cancer”. Biochimica et Biophysica Acta, (2003). 1653 1-24. http://dx.doi.org/10.1016/S0304-419X(03)00005-2

This review considers the spectra of tumors arising from active Wnt signaling and attempts to place perspective on recent data that begin to elucidate the mechanisms prompting uncontrolled cell growth following induction of Wnt signaling.

--Z3289738 10:48, 29 March 2012 (EST)




Check this out. It's a website all about the Wnt pathway. It has a list of virtually all review articles on the pathway.

http://www.stanford.edu/group/nusselab/cgi-bin/wnt/wntreviews




<pubmed>9529612</pubmed> A review of the Wnt/beta-catenin pathway and the protein and receptor interactions involved.


<pubmed>9407023</pubmed> Outlines the evidence for the interaction of the Frizzled receptor with the Wnt protein.


<pubmed>15001769</pubmed> Explores the interrelationship between the Wnt, beta-catenin and cadherin pathways by examining the role of receptor activation and repression to control gene expression.


<pubmed>15652476</pubmed> Newer research made possible by advancements in imaging technology have better elucidated the finer interactions in the Wnt/beta-catenin pathway.


--Z3336051 23:36, 25 March 2012 (EST)




<pubmed>19619488</pubmed> Overview of the Wnt signaling pathway; ligands, agonists and antagonists and their interactions with Wnt receptors. Also mentions its implication in the development of human disease.


<pubmed>12775774</pubmed> Main extracellular antagonists of the Wnt signalling pathway - regulation of cell growth/differentiation.


<pubmed>19279722</pubmed> Involvement of Wnt signalling molecules in the control of embryonic development.


<pubmed>18392048</pubmed> Role of the Wnt pathway in proliferation, differentiation and apoptosis in adult tissues (and therefore oncogenesis).


--Z3332227 12:27, 25 March 2012 (EST)




Thank you so much Li! I'm happy with the allocations...here are my references for this week's homework


<pubmed>16793760</pubmed> This review article provides a concise overview of the Wnt/Beta Catenin Signalling which can used in the introduction.


<pubmed>15372092</pubmed> There are a number of clearly labelled diagrams in this article that can be used as a starting point for the student drawn image.


<pubmed>18673238</pubmed> This article provides an historical overview of the key events that shaped our understanding of Wnt/Beta Catenin signalling and hence can greatly aid the history section.


<pubmed>17081971</pubmed> This review also contains many simplified diagrams that can be used to support the student drawn image.

--Z3333421 22:32, 22 March 2012 (EST)




Unfortunately we didn't get notch signalling, so we'll go with Wnt/beta-catenin signalling? To Natalie, the reason we didn't go with JAK/STAT was because of the apparent lack of research available on it. Wnt/beta-catenin seems better understood.


The following is a recommended assignment of sections, so we can get to our homework which is to each find four references for our respective assignment sections.

If you would like to swap, these roles are negotiable, but keep in mind that our homework is due next week.

  • Introduction + History + pathway images (at least one drawn) - Sara
  • Normal Function - Sam
  • Abnormal Function - Natalie
  • Receptors involved + (if applicable)Proteins involved - Li

To Sara, I wasn't quite sure how to divide up the subheadings based on the roles you wrote down, but you're free to reassign if you can elaborate for me. The above is my attempt at filling in the details.

Finally, I will look after maintenance of page formatting. Come to me if you have any questions.

--Z3336051 16:46, 22 March 2012 (EST)




Hey guys, If we decide to go with notch signaling here's a really great diagram & description: http://www.cellsignal.com/reference/pathway/Notch.html

--Z3289738 14:28, 22 March 2012 (EST)