Talk:2011 Group 5 Project

From CellBiology

Post Peer Assessment Discussion

Hey guys in response to the peers i moved around my pictures, gave them text under them, and added a lot of new information and some photos to the structure section. the only issue we have left is to clean up our reference list since it mostly looks like a bunch of pubmed IDs. i guess we will ask mark what to do with this.--Michael Orenstein 21:48, 25 May 2011 (EST)

Week 7

  • This is the week before the mid-session break.
  • In the lab this week we will have an opportunity to discuss any issues which are slowing progress on your project.
  • The Thursday of the week beginning 02 May will be when all projects will be open to Peer Assessment.
  • What you have on your page by Thursday of that week will be the content that others in the class will comment upon.

Week 6

  1. I see many groups now have subsection titles for their projects.
  2. Here are some searches: Pubmed search all databases junction | PLoS junction | JCB junction You can now simply put your own search term into each top window.
  3. Now's the time to get your images, movies, media etc uploaded. Biomed central | JCB | JCB Archive | PLoS. Once uploaded you can make a gallery on either your project or discussion page using <gallery>File:name here</gallery> tags with your image files listed between the tags. When you upload project images, add this text as it appears replacing # with your own Group number to the summary information [[Category:2011Project#]].
  4. Shown below are the criteria that will be used to assess your final project.

Group Assessment Criteria

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.

By Week 5

Each Group member has added to the discussion page:

  1. A Review Article
  2. A Historic Research Article
  3. A Current Research Article

No two students should add the same paper and there should be a link to the original article.

Peer Assessment

Group 5-Adherens Junctions

  • Intro – A picture of adherens junction would be appealing and more illustrative.
  • History – is there more discoveries in between the time periods?
  • Structure and Function – Format some of the information into dot points may be helpful to condense down the key information. Addition of figures in the Function section or videos may be more illustrative. Also subheadings could make the both sections easier to read.
  • Importance and Regulation – subheadings.
  • Abnormalities in Disease – I like the layout of this section. But how does the underlying cellular pathogenesis of UC and CC lead to the clinical manifestation of these two diseases?
  • Current Research – this section is very good.
  • Other types of Cell Junctions – is this section necessary?
  • Glossary – There’s no definition of homophilic binding

Group 5

Helful images both referenced and from the studnets compliment the written text. This page is well balanced with sensible headings, building comfortably on itself from the start to finish in terms of content. This is beneficial for the reader as he/she can easily learn from what is on the page, which fulfils this criteria to an extrermely high level. The table giving other types is a good idea, however, it does seem a bit extensive for something that is not on the topic. Conversely, it works well with it's images to provide a means of comparison between adherens junctions and other types. The inclusion of several external links throughout is great, as this page can now be used as a base for further study into the subject. If a section is dedicated to external links,then perhaps more than one should be listed. The history does seem a little short, both in number of dates and amount of detail for each major event.

Group 5

Hey guys, you have an awesome page! However I have a few things that you could improve on. The history seems abit too brief. A few more dates and key figures that led up to not just the discovery of this junction but rather the function or their role in diseases would be good. Furthermore, for the disease section, the use of bigger headings for the title of the diseases would be better for the readers. Other than that, it is an awesome page :)

p.s. Is it really necessary to discuss the other type of junctions in that much detail?

Group 5

-The intro part is too short and it needs some images.

-You guys should use some dot points for functional and structural parts , so readers can understand and follow the content better.

-Overally,not bad.

Group 5

  • When I first look through your project I see lots of images, which seems to balance out the text nicely
  • There are a few grammatical errors that should be fixed. This will make it easier to read the text smoothly
  • With the history section, it may be helpful to look at some discoveries after 2000. I am sure they have happened.
  • Homophilic binding is defined twice within the text, make sure you go through and make sure there isn’t any overlap between sections.
  • The function section is written really well and is very interesting.
  • There is lots of capitalisation of words in places where it is not necessary, and also a few typos.
  • Overall your project is easily read and understood as well as being interesting. There are a few minor issues with prrofreading but other than that your project seems very close to complete.

Group 5

  • Introduction is a short literature text format so need to be changed
  • A picture for this particular junction needs to be added.
  • History is short, not finished.
  • Structure stands good with the drawn diagram.
  • Function is short and is not balanced visually (@ least one picture must be added).
  • A good presented table which describe other types of cell junctions.
  • Current researches good, however there is nothing on future studies.
  • Glossary not finished.

Group 5:

  • Maybe add an initial picture of an adherens junction? Just an idea to grab peoples attention.
  • History section is really short, did anything else happen between 1839 and 2000? Try google timeline, then search pubmed for the papers for referencing
  • Student drawn diagram is really good, to the point and makes sense!
  • glossary is incomplete
  • I like how you have added links to videos to explain some of the concepts, makes it easier to understand!
  • The table with different types of cell junctions is a great idea, and i liked how youve linked it back to other group project pages
  • Any info on future research?

Adherens Junctions

  • There isn’t too much to the history, check for some more recent work, ie after 2000.
  • You might want to rethink some of the wording in the intro, not a huge problem but it might help with the flow.
  • The pictures and info in the “structure” section is really good. I like the addition of the video, it keeps it interesting. Cool video.
  • Function is alright, I see you’ve said there isn’t much known about it, but can you maybe elaborate a bit more on the points you have made? Are there examples to show this? Any idea of the mechanism behind embryogenesis? etc
  • A couple of grammatical errors in “regulation” section
  • In regulation section, “growth factors, the peptide hormones and …etc.”. What exactly do you mean by “and…etc”? Come up with one more example and replace the etc, it would just seem more official.
  • Other than that, the information in the regulation section is quite good, I like the set out.
  • “Abnormalities in Disease” doesn’t quite make sense. Maybe “Abnormalities and disease”, “Abnormalities causing disease”? Something like that.
  • Abnormalities section is quite good, good overview of a few diseases, interesting.
  • The addition of the current research is really good
  • The table at the end is pretty good, nice overview of other junctions.

Group 5

  • A number of typos and awkward syntax make the "intro" and "importance & regulation" sections difficult to read
  • History events are well linked to the topic, however there could definitely be some more!
  • Structure is explained well. What is the difference between classical and non-classical cadherins?
  • The video is really helpful
  • Function section addresses the question well. Maybe some more in-depth information about their function within specific tissue types would be good?
  • ”at this site are; growth factors, the peptide hormones and …etc.” Etc?? Why don’t you tell us all of them? You could use dot points if you don’t want a long sentence listing them?
  • "Abnormalities in Disease", I know what you mean, but it's a bit of a tautology when written like this.
  • Nice work explaining how AJ’s are related to each individual disease. I can imagine this would have taken a lot of work and thorough research!
  • Good variety of current research included.
  • Seeing you wanted to include a table of all the other junctions, I think you should put it somewhere towards the start and explain why this is relevant to your particular topic, instead of just throwing it on the end.

Group 5: Adherens Junctions

Introduction: The introduction's sentence structure is a bit difficult to understand. Whilst much of the content is there, it could be written a bit clearer. Also a bit of an overview on what will be discussed would be helpful for the reader.

History: The history has too few enteries, however the layout makes it easy to read and understand.

Structure: The structure is informative and the adjoining pictures are good, giving the reader an idea of their form on a molecular and what they actually look like through a microscope.

Function: Whilst the section is clearer, it could be made even more accessible by the addition of subheadings for the main functions.

Importance And Regulation: The link to the picture at the beginning of this section does look very detailed and important to your subject, however it may be better to either explain the link or upload the actual picture to the page. Also the extracellular regulator sentence would be more informative and professional if you finished listing the regulators. In addition, the grammar in the last sentence of the section does not seem to flow. Is it meant to say, "if quite"?

Abnormalities: This topic on adherens junctions is very well explained.

Research: It looks as though you have current research areas with good links, although the actual content is sometimes not easily understood. An example of this is, "They were able to characterise. The proteins function, expression and localisation whist also labelling the junctions regions within cultured kidney cells. Specifically they established that definitively establishes that PLEKHA7 is localized at the adherens junctions in colonic epithelial cells."

Other Types Of Cell Junctions: Good formatting and pictures.

Glossary: The headings of the letters may be a simple touch, but is enough to make this an easier read.

Our Image Gallery


Hey guys so i think Mark put on our page a list of subheadings that he wants us to use... So ill put it up and again we can put our name next to the ones we want to do. There are 8 so 2 each. I think ill also keep with the table i started on the page and make that another heading maybe.

1. IntroductionEsther

2. History alex

3. Structure Tegan

4. Function alex

5. Hemidesmosomes Tegan

6. Importance and regulation Esther

7. AbnormalitiesSal

8. Research methods Sal

--z3292208 10:29, 11 April 2011 (EST)


Ok guys so 2 of you emailed me back about changing the topic, so if we choose the last topic offered Adherens Junctions I thought this might be good lay out:

  1. Introduction What are Adherens junctions in cells? What types of proteins constitute these? Where in the cell do they occur? What is the function of these junctions (brief)? Tegan
  2. History Who discovered them? How has our knowledge of them increased over time? SAL
  3. Function/importance of Adherens Junctions What are the main functions of these junctions, explained in detail one by one. Can the body live or function properly without these? Z3254433
  4. Formation of Adherens Junctions How do these junctions form, what are the steps of development. e.g first step: the organization of actin filaments ..etc. Esther
  5. Other types of cell junctionsComparison of these to other cell junctions, maybe in a table with some pictures of each. Tegan
  6. Diseases That affect the Adherens Junctions SAL
  7. Current associated research Is there any research being conducted presently about these junctions? SAL
  8. Conclusion Final Overview of the topic.
  9. External links
  10. Glossary
  11. References

Articles to Read/look at

Just wanted to put the links somewhere


Nature Cell Biology



PLoS Biology

Free to re-use:

Not sure/Cannot Freely re-use:


I dont understand what you mean about the pictures.....

Also guys we should go through our sections and put any words we think readers might not understand into the glossary section at the bottom of our page. We can take words from Mark Hill's glossary [Cell Biology Glossary] or if the words aren't there I just looked them up online and put in a reference.

Tegan --z3292208 11:15, 11 May 2011 (EST)

--Kyung Ma 22:56, 10 May 2011 (EST) otherwise, the File:Cadherin2.gif from the lecture note that i put up in our gallery looks fine too

--Kyung Ma 22:52, 10 May 2011 (EST) I mean you can delete the one in my section and replace it if you want.... i just wanted readers to know where the regulation is happening visually but if it is in function section, then that is fine you know?

I think it looks good Tegan, no need to change it! --Sally Clarke 22:12, 10 May 2011 (EST)

I drew that original pic cos i need one in my structure section so i dunno if you want me to replace that one with the one you did?

You dont need to reference the pictures from lectures, just use the name of the file in the brackets to put it on the page and thats all you need to do.

Tegan. --z3292208 18:42, 10 May 2011 (EST)

hey i think the pic would already have a ref in its description section. BTW does anybody know why my pic isnt working???? its in our gallery. --z3254433 19:14, 6 May 2011 (EST)

--Kyung Ma 14:18, 6 May 2011 (EST) I drew another version of File:Adherens Junction Diagram.jpg through the paint tool... may be you want to use this instead of hand drawn one? And can we put that up in the introduction?

--Kyung Ma 13:19, 6 May 2011 (EST) Can I upload the picture from the lecture note? and if so, do we have to reference it fully?

--Kyung Ma 09:39, 5 May 2011 (EST) So the thing is I don't know if my importance and regulation section is enough... I can go in to more detail but i thought that I will take too much space since i have to go on and on... tell me what I should write more on or less on

--Kyung Ma 09:27, 5 May 2011 (EST)

yeah apparently the peer assessment by other groups are on next week so what Mark said was to read each others section that we've done, and tell each other if we have to go in to more detail or summarise it and stuff....

hey guys it says on the bottom of our page everyone has a week extension for the peer assessment?! true??

tegan--z3292208 22:56, 4 May 2011 (EST)

hey don't panic i have the section on history, i'll have it put up by tonight after i proof read it, i'm just working on another report atm! i am worried that we don't have enough pics, but i can't seem to find any others that haven't been used already! also the pic in the structure sec is too big i think so i might resize it later and see if it looks better?!

--z3254433 15:59, 4 May 2011 (EST)

Hey, someone in another group told me they had that same problem that they lost their work and i think to get it back you have to go through the history of the page maybe? Goodluck with it! Current research sounds good, i think thats what mark wants.

Also whats happening with History and Importance and Regulation anyone?? Also I think function sounds great but maybe needs more detail? Im gonna add a bit more detail to my structure section today.

Tegan --z3292208 09:15, 4 May 2011 (EST)

Ok so Research Methods I'm taking as Just Current research unless anyone thinks of something else to include there because all i got is looking under microscopes.. well more detail than that but not really about Adherens Junctions specifically. Also I'm going to add a blurb about each of the articles tomorrow night!

--Sally Clarke 23:20, 3 May 2011 (EST)

Ok so problem - i was editing my section and someone must have been editing the page at the same time and now its all stuffed up... kind of lost some of my text and i don't know where to find it! Anyone know whats happening? --Sally Clarke 22:19, 2 May 2011 (EST)

Try looking on Flicker like i said before to Tegan, Its has a lot of free to reuse images.

--Sally Clarke 13:11, 2 May 2011 (EST)

--Kyung Ma 13:09, 2 May 2011 (EST)

Heyy guys I just uploaded introduction... and I'm planning to upload the importance and regulation tonight or tomorrow morning! I'm so sorry for late uploading! I was staying at my parent's house during the break and we don't have internet there so... haha But the thing is I couldn't find any image that is freely distributed...

Sweet ill check it out tonight thanks. --z3292208 09:27, 2 May 2011 (EST)

Strangely enough, for pictures i have found that flicker is really good as a lot of the images are free to reuse and to edit! That's where i found the last two so try your luck there!

--Sally Clarke 09:14, 2 May 2011 (EST)

Yep you said you were on track so all good! The diseases section looks good! Hopefully our page will be looking awesome by thurs. I still need to add to my sections. And having trouble getting a couple of pics too....

Tegan. --z3292208 08:37, 2 May 2011 (EST)

No problems just wanted to let you know that i do have stuff I'm just trying to make it all Copyright-able... If that makes sense. Youve done a great job.

--Sally Clarke 17:39, 1 May 2011 (EST)

Ok thats cool Sally, thanks for getting back to me.

Tegan --z3292208 13:14, 1 May 2011 (EST)

Hey Tegan, I'm having problems with copyright and such. All the info that i have found is copy righted so I'm adding it to links and searching for fingers crossed, more material --Sally Clarke 12:18, 1 May 2011 (EST)

Hey, hows everyone going with their sections? Page is looking a little empty compared to other groups. Let me know how you're all going!


--z3292208 12:06, 1 May 2011 (EST)

Hey guys - we are ONLY focusing on the 8 dot points mark has outlined for us bellow. Formatting of page, conclusion, Glossary, finalised references, editing and proofing are all to be done when we have finished those 8 dot points. See you all tomorrow? --Sally Clarke 20:32, 20 April 2011 (EST)

Hey 3291200 Kyung Ma, introduction is just opening the page, saying briefly what the junction is and what the page will be about etc. I dont think its fair if you do introduction and conclusion, if you dont want to do Importance and Regulation maybe change that and do Formation of Adherens Junctions instead? I dont think we need to worry about a conclusion yet, we can do that at the very very end, lets worry about the rest of the page for now. --z3292208 19:24, 20 April 2011 (EST)

--Kyung Ma 10:36, 20 April 2011 (EST)

1. A Review Article Dynein binds to b-catenin and may tether microtubules at adherens junctions Molecular architecture of adherens junctions

2. A Historic Research Article Spatial and temporal distribution of the adherens-junction-associated adhesion molecule A-CAM during avian embryogenesis

3. A Current Research Article

--Kyung Ma 10:20, 20 April 2011 (EST) I'm not confident with the research methods so I choose conclusion but does that mean when we are finished with all the other stuff i briefly summarise the things that everyone wrote?

--Kyung Ma 14:29, 12 April 2011 (EST)

Hey guys I choose introduction and importancce and regulation... introduction is meant by the general information about adherense junction right?

I think the most useful ones are the historical article above (2 or 3 from the bottom) in the not sure to freely reuse section but i think its not copyrighted... i couldn't find the copyright info anywhere so maybe you will have better luck on it. It gives a good overview at where they were at in 2002.

--Sally Clarke 09:26, 19 April 2011 (EST)

sure why not, thanks sally

--z3254433 07:55, 19 April 2011 (EST)

z3254433 if you are having problems with research methods You can do history instead and I can do research methods. A lot of the articles I have found above will be useful.

--Sally Clarke 20:56, 18 April 2011 (EST)

Hey these are the headings mark wants us to do so im not sure what he wants in a couple of them, i think im gonna ask him about my number 5, but for research methods it might be what research techniques scientists used to find out about the junction? It could also include any research that is currently being done about the junctions?

--z3292208 18:10, 13 April 2011 (EST)

  • sorry guys i'm not sure that i fully understand the heading research methods,is anyone able to give me a guide at what i need to write in this section?

--z3254433 10:35, 13 April 2011 (EST)

Z3254433 and Esther, you need to do 2 topics (as Tegan and i are doing 2!) there is conclusion and further research - Chuck your names next to them as you want and then lets get started! --Sally Clarke 09:15, 7 April 2011 (EST)

Hey guys so i was looking at the outline and we seem to have 2 headings unclaimed and one person missing?

This would be good for the development of the junction Model of the Evolution of Cell Adhesion Junctions


--z3292208 11:23, 6 April 2011 (EST)

The articles we need for this week:

1. review article Plasma membrane components of adherens junctions (Review)

2. historical article Polymorphonuclear Leukocyte Adhesion Triggers the Disorganization of Endothelial Cell-to-Cell Adherens Junctions]

3. current article aPKC Controls Microtubule Organization to Balance Adherens Junction Symmetry and Planar Polarity during Development

--z3254433 11:19, 6 April 2011 (EST)


1. A review article VE-cadherin: at the front, center, and sides of endothelial cell organization and function

2. A historic research article Discovering the Molecular Components of Intercellular Junctions—A Historical View

3. A current research article A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation

--z3292208 10:50, 5 April 2011 (EST)

Hi Guys, So i added a few (ok sorry but i just got on a role and was sitting around at work waiting) articles and I think they are mostly really good. They don't really go into specific antibodies etc but are more overviews of the Whole Adherens junctions themselves. Take a look if you like, i think we are still missing one person in our group. Hope you have a good one

--Sally Clarke 14:25, 1 April 2011 (EST)

Also just a thought maybe we should look into diseases where the Adherens junctions have been affected ie. Pathogenic Hantaviruses. This is a great paper on it and really interesting. Maybe we can make another small group for this info.

Pathogenic Hantaviruses Andes Virus and Hantaan Virus Induce Adherens Junction Disassembly by Directing Vascular Endothelial Cadherin Internalization in Human Endothelial Cells{triangledown}

--Sally Clarke 16:23, 31 March 2011 (EST)

Just wanted to put the links somewhere


Nature Cell Biology


I thought i would put my name against the ones i was going to do, hope this is ok with all. We now have 6 topics (the last three i think we should all just do together as we will know when we have references, new key words etc.) coolies? --Sally Clarke 10:30, 31 March 2011 (EST)

Hi guys, ill do number three by the way are there any other topics that you would like me to do?

--z3254433 21:42, 30 March 2011 (EST)

Ah i see good idea! I moved it around so it makes more sense now! --Sally Clarke 09:28, 30 March 2011 (EST)

Hey lots of articles! cool ill check them out today. also add stuff to the top of the discussion page so when we look at it we dont have to scroll all the way down to the bottom :)


--z3292208 09:27, 30 March 2011 (EST)

Hey Tegan, This looks great. I found some good articles about it as well.

This one is great Endothelial adherens junctions and the actin cytoskeleton: an 'infinity net'? - Free to re-use information and images - Free to re-use information and images

Adherens Junctions dynamic

The role of adherens junctions and VE-cadherin in the control of vascular permeability. I can see full article but can't find copyright info.

I would like to do number 6 - current research adn maybe 2. There are only 5 topics and there are 4 of us so I'm going to keep looking around and see if we can add any more.

--Sally Clarke 09:21, 30 March 2011 (EST)

So we should split up the sections if you guys think this layout is ok, I wouldnt mind doing 1 and 4. Tegan.

--z3292208 18:39, 29 March 2011 (EST)

Hey guys as Mark said this is a new topic so we might have trouble finding information on it, I reckon we should look at doing something else then because we'll need lots of references to make the page.

The last topic there is Adherens Junctions.

What do you guys think?

--z3292208 12:52, 27 March 2011 (EST)