Difference between revisions of "Talk:2011 Group 4 Project"

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==Peer Assessment==
==Peer Assessment==
Group 4
*Introduction: Too short and it definitely needs at least a picture.
*History: A few more images would be better.
*Structure: Introduction to the structure of desmosomes, you do not need another intro when u already have one at the top. So, this one can be merged with the one at the top.Structures on 2 different levels; good organising.Outer dense plate; you might wanna consider making a brief intro to it , as it kind of so unfamiliar to  regular readers.
*Related diseases and research: They are alright.
*Overall: the headings are confusing , in particular ,in structural part.
'''Group 4-Desmosome'''
'''Group 4-Desmosome'''

Revision as of 03:07, 18 May 2011

Peer Assessment

Group 4

  • Introduction: Too short and it definitely needs at least a picture.
  • History: A few more images would be better.
  • Structure: Introduction to the structure of desmosomes, you do not need another intro when u already have one at the top. So, this one can be merged with the one at the top.Structures on 2 different levels; good organising.Outer dense plate; you might wanna consider making a brief intro to it , as it kind of so unfamiliar to regular readers.
  • Related diseases and research: They are alright.
  • Overall: the headings are confusing , in particular ,in structural part.

Group 4-Desmosome

  • Intro – needs more general description of desmosomes, its structure and function as well as a line or two on introducing the following content.
  • History – very extensive and no huge gaps in between.
  • Structure – The intro in this part could be simplified and maybe moved to the introduction section?
  • Function – addition of dot points might help to simplify the information and make it easy to read.
  • Related Diseases – one or two more diseases in this section would be good. Brief prevalence and treatment for each disease would be desirable.
  • Glossary – needs expansion by including words like haploinsufficiency etc.
  • Current research – more studies may be added.

Group 4

Very well done. This is very technical and is very well research. High level of detail requiring specific knowledge that is not covered on the page. This page needs a glossary to explain terms, although it is meant for peers the technical nature of the page requires some explanation of terms to make the page more accessible. Not sure if it's worth a mention, but the pubmed references could be done differently to give info about the resource on the page. The introduction is relevant but short, maybe including slightly more detail or theimportance of this junction would help. Besides these small details, I found this page incredibly informative with the amount of depth and detail, great work guys.

Group 4

Good work group 4. It is a very detailed yet concise page! However for the introduction and the function of this junction needs abit of fleshing out. The introduction seems abit to brief. Maybe the brief mention of what you will be talking about throughout the page or even just going into abit more detail to get the readers interested in this topic. For the function section, use of examples would be better to allow the readers to have a better grasp of what you are talking about. I like your groups use of pictures, they go really well with the text. Good work guys!

Group 4

-the introduction is too short ,it needed some images and “ the introduction to the structure of desmosomes” below the history should go to the actual introduction of the project , as it briefs through a little of each aspect of the topic.

-it is hard to follow , in particular when I reach the dense plate part, like where in desmosomes those dense plates are?

Peer review

  • Intro – Add ganglia to glossary? May be a labelled diagram showing the general anatomy of neuron, axon, ganglion, synaptic junction etc would be more illustrative and saves words.
  • History – has there been any discoveries after 1981?

What is a synaptic junction-Good use of diagrams and descriptions are clear and concise.

  • Types of synaptic junctions – Great summary at the end put into a table. How they function may be better illustrated by a video.
  • Synaptic Integration and Modulation – Brief description of what synaptic integration and modulation are at the beginning of the section may be helpful in providing the context to later contents. I assume that the content under subtitle “The action potential and summation” describes synaptic integration? “IPSPs or EPSPs” shouldn’t be abbreviated the first time they appear though I can see the full name in Glossary section.
  • Neurotransmitters – this section is greatly done! I like the combination of brief paragraphs, use of table and picture
  • Diseases Associated with Synaptic Junctions Dysfunctions – Medical jargons such as “substantia nigra”, ”lewy bodies” might be difficult for non-medical readers to understand. Add to the glossary in the end or links to external website may be helpful. Overall I think this section is too medical, it’ll be a great section for a med assignment but for cell biology I think there’s a bit too much information.
  • Current and Future Research and Developments – One or two more studies would be great; otherwise this section is well written and presented.


  • Intro: Too short and needs overview of what is occurring on the page. Maybe add an image as well.
  • History: More images maybe and put the image to the right side maybe, wrapped by text, Does that make sense? Well written.
  • Structure: Great that you got permission but it doesn't need to be included at the top on the page. Maybe make a reference to it when you discuss the paper.
  • Function: Heading a little confusing i would consider revising grammar for these ie: 'Desmodome as (a) cellular adhesion junction' - needs the a included at least. Also you launch straight into this section so maybe add a little preamble as to allow the reader to follow your thoughts rather than jumping from topic to topic. The images here need to have the website added into their image page and the last image falls bellow this section.
  • Hemidesmosomes: the link here needs to be formatted with the title of the page.
  • Regulation: Images should really move to be wrapped on a side so as not to impede flow and they need copyright info and a link to the location they came from.
  • Disease: Images here need captions and to be wrapped in the text rather than creating lots of extra white space.
  • Current Research: Too short and needs more articles and research being done.
  • Images and video: Add ALL the images from the page into here otherwise it is a bit of a waste of space. Also format the link properly!
  • No glossary???

Group 4

  • Obviously, introduction=not done.
  • At least a picture is needed to draw attention of the reader.
  • History good.
  • Structure needs to be fixed (add pictures, ordering the text, right subheadings).
  • Function is good.
  • “Knock out” is a good idea.
  • Regulation section maybe a table is needed.
  • Diseases are presented good (just fix the design).
  • Current research not finished.
  • References need to be fixed.
  • Overall, not enough text in many parts of this group project, not enough pictures, not tables etc, therefore this research is not completed yet.

-there is a few of grammar mistakes and typos,like under the intro part "neurones are a specialised cell", under the subheading of what is a synaptic junction , first line,"between to nerve cells".

-the terms or text in images are hardly seen as the text is either fainted or too tiny and the page isnt resourceful enough to me.

Group 4

  • Like the subdivisions in structure. There’s an excellent summary of function in this section “other roles including strengthening the internal structure of a cell, sensing environmental cues, regulating tissue homeostasis and assisting in tissue morphogenesis”, which I think would be better in the function section. It gives a better general outline of the roles than the info that is currently in functions. Some of the roles mentioned in the structure section aren’t even mentioned in the function section.
  • As with all of the groups there are a few typos and grammatical errors
  • Good use of relevant literature to explain desmosome regulation. Was also a good segue between function and disease
  • Surely there is more than one current study?

Hi guys, someone accidentally edited the template at the bottom of the project page instead of editing your project page so your group sub headings were on everyones project page instead of just yours. when you edit a page, make sure you are editing your group project page, it is really easy to edit another page without realising it. (ive done that before too). Ive fixed it for you :) Hope this makes sense :) -Jill (group 6)

Post Peer Assessment Discussion

Hey guys in response to the peers i moved around my pictures, gave them text under them, and added a lot of new information and some photos to the structure section. the only issue we have left is to clean up our reference list since it mostly looks like a bunch of pubmed IDs. i guess we will ask mark what to do with this.--Michael Orenstein 21:48, 25 May 2011 (EST)

Week 7

  • This is the week before the mid-session break.
  • In the lab this week we will have an opportunity to discuss any issues which are slowing progress on your project.
  • The Thursday of the week beginning 02 May will be when all projects will be open to Peer Assessment.
  • What you have on your page by Thursday of that week will be the content that others in the class will comment upon.

Week 6

  1. I see many groups now have subsection titles for their projects.
  2. Here are some searches: Pubmed search all databases junction | PLoS junction | JCB junction You can now simply put your own search term into each top window.
  3. Now's the time to get your images, movies, media etc uploaded. Biomed central | JCB | JCB Archive | PLoS. Once uploaded you can make a gallery on either your project or discussion page using <gallery>File:name here</gallery> tags with your image files listed between the tags. When you upload project images, add this text as it appears replacing # with your own Group number to the summary information [[Category:2011Project#]].
  4. Shown below are the criteria that will be used to assess your final project.

Group Assessment Criteria

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.

By Week 5

Each Group member has added to the discussion page:

  1. A Review Article
  2. A Historic Research Article
  3. A Current Research Article

No two students should add the same paper and there should be a link to the original article.


--Mark Hill 14:17, 20 April 2011 (EST) Looking at your discussion page there appears to be group members not actively contributing to the work. I remind all group members that your final mark will also be based upon your contribution to the project during its development phase.

ests edit

--Mark Hill 17:14, 30 March 2011 (EST) OK Group 4, Just one student (Z3288729) trying to organise an online discussion to date and no content added by any other group member to either your discussion or project page. Also no response to Z3288729 request about the project topic. You were meant to have already begun looking into both the topic and references, pasting links on your discussion page. I will see you in the lab tomorrow to discuss whether you are having problems or are simply not doing the work. This search should get you started. Search Pubmed: Desmosome

--Zaid Imtoual 20:37, 27 April 2011 (EST)


--Sarah Jenkins 13:25, 10 May 2011 (EST) Hey im just trying to fix up the glossary and all of the things i have in it are cadherins and its getting very repetitive. is it really necessary to have a glossary ??

After anzac day

--User:Z3129413 20:37, 27 April 2011 (EST) I have a question for the group: in Function I have started to take the individual protein components of the desmosome and am trying to outline from the relevant studies their individual function besides the obvious contribution synergistically as a whole to the binding of two cells together. Desmoplakin for instance and its implication in vascular proliferation via microtibule regulation. I can see no other way (at the moment) to tackle the function subject. Is this acceptable.?

--Sarah Jenkins 09:09, 29 April 2011 (EST) If this is the most effective way of doing it then it is fine. as long as at some point you show what its functions are as a whole. another way of organising it is, instead of dividing it into individual proteins and their functions, dividing it into functions and then relate it to each of the proteins? hope this helps.

Week 9

I went through and changed the references on our page like Mark suggested. from what I can see, the page is now working fine so feel free to upload your work now :) --Sarah Jenkins 07:41, 4 May 2011 (EST)

Week 7

who deleted some of the subheadings from our page??? is it not important to talk about hemidesmosomes and related abnormalities?? please explain why you are deleting things before you do it. the rest of the group is only going to get confused! --Sarah Jenkins 09:10, 15 April 2011 (EST)

== WEEK 6-7: I have set up some subheadings on our project page. We really need to get a move on and start some writing soon if it is possible. I think we may even have to meet up to discuss how our group work is going===--Sarah Jenkins 11:07, 10 April 2011 (EST)


It looks like everyone has found some articles, so would it now be possible to start the writing process this weekend? We dont need alot here but it would be good to start bringing our ideas together --Sarah Jenkins 10:47, 6 April 2011 (EST)

do we write straight to the other main page? z312--User:Z312 19:29, 10 April 2011 (EST)

Yes, it is probably easier that way as this page looks like a disaster at the moment. Just make sure that everything is also properly referenced. --Sarah Jenkins 17:10, 12 April 2011 (EST)

Firstly, is everybody happy with the topic that was decided upon last week? Next, we need to divide ourselves into sections of the topic. What if we divided it into:

Structure and function

Related abnormalities

Current research methods

Current and future possibilities for research

I personally would be most interested in researching the related abnormalities.\

(z3288729) S.J

(z3217345) M.B (Preference for structure and function)

(z3289066) E.K current research methods is good

I think that we need to go into a lot more detail with the layout and division of work between us. If anyone could help with this it would be much appreciated. We could possibly look into how they were first discovered also? I had a quick look at function, and there is HEAPS. This should become a separate subject area. With structure, we could look into location within the cell as well? Hemidesmosomes needs to be addressed, not in a huge amount of detail but it cannot be ignored. --Sarah Jenkins 11:01, 30 March 2011 (EST)

Since there won't be much information about current research methods, I'm happy to do hemidesmosomes as well.--Elisabeth Karsten 11:04, 30 March 2011 (EST)

Great. I was thinking that we shouldn't have way too much on related abnormalities, so I can work on the structure as well?? And then leave function to Z3217345 --Sarah Jenkins 11:07, 30 March 2011 (EST)


I am happy to take on the role of team manager if everyone thinks im up to it? I agree that we do need some authority and I like the idea of all of us working on each section before moving on to the next one. --Sarah Jenkins 08:52, 31 March 2011 (EST)

Research Areas

Structure and function


Journal Articles

Desmosome structure: http://www.ncbi.nlm.nih.gov/pubmed/17945476

Desmosome: http://www.ncbi.nlm.nih.gov/pubmed/20066089

Desmosomes: adhesive strength and signalling in health and disease: http://www.ncbi.nlm.nih.gov/pubmed/20626351

General desmosome information: http://www.ncbi.nlm.nih.gov/pubmed/20066089

Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes: http://www.ncbi.nlm.nih.gov/pubmed/21071449

Cellular and molecular biology of the desmosome: - Mechanical continuity is provided by desmosomes and adherens junctions http://www.ncbi.nlm.nih.gov/pubmed/20847325

The desmosome in the epidermis and myocardium: http://www.ncbi.nlm.nih.gov/pubmed/18957846

Desmosome structure, composition and function: http://www.ncbi.nlm.nih.gov/pubmed/17854763

Biochemical Characterization of the Desmosome: http://www.ncbi.nlm.nih.gov/pubmed/21270806

Regulation of desmosome assembly and adhesion: http://www.ncbi.nlm.nih.gov/pubmed/15561586

Mechanisms of desmosome assembly and disassembly: http://www.ncbi.nlm.nih.gov/pubmed/12472547

The desmosome: structure, function and acquired pathology: http://www.ncbi.nlm.nih.gov/pubmed/7854861

Articles From Respected Cell Biology Journals

Intermediate filaments and the initiation of desmosome assembly (Journal Of Cell Biology): http://www.ncbi.nlm.nih.gov/pubmed/3894376

Structure and assembly of desmosome junctions (Journal Of Cell Biology): http://www.ncbi.nlm.nih.gov/pubmed?term=Structure%20and%20assembly%20of%20desmosome%20junctions%3A%20biosynthesis%20and%20turnover%20of%20the%20major%20desmosome%20components%20of%20Madin-Darby%20canine%20kidney%20cells%20in%20low%20calcium%20medium.

Cross-Talk between Adherens Junctions and Desmosomes Depends on Plakoglobin: http://www.ncbi.nlm.nih.gov/pubmed?term=Cross-Talk%20between%20Adherens%20Junctions%20and%20Desmosomes%20Depends%20on%20Plakoglobin

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA : http://jcb.rupress.org/content/17/2/375.abstract?sid=984020cb-0141-4d27-90c2-5f0c533e9fcb

Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly: http://www.ncbi.nlm.nih.gov/pubmed?term=Breaking%20the%20connection%3A%20displacement%20of%20the%20desmosomal%20plaque%20protein%20desmoplakin%20from%20cell-cell%20interfaces%20disrupts%20anchorage%20of%20intermediate%20filament%20bundles%20and%20alters%20intercellular%20junction%20assembly.



  1. <pubmed>20066089</pubmed>

Related abnormalities


Current research methods


Current and future possibilities for research

Sarahs idea of z31 (me) doing function alright? So i cover ongoing/ future research and function?

Perhaps a collaboration of everyone for every topic, in that everyone submits the key pointers they think the allocated person for that topic should cover.. might lead to a more fluid overall project . I propose we elect a project manager, whom we all argue our cases to of how the project is being directed.

In terms of what a desmosome is and what it does maybe every team member will want a say on how this is portrayed. The project manager can then decide the best possible final content. One person kicks off structure and somebody does function, then individual team members forwards suggestions regarding improvements/ detractions to the project manager . Then the next topic is done. In sequence...might get the project done faster this way.

In this way every topic will become of the group mind. I've read some of the other previous projects and sometimes it looks like four individual projects stapled together.

So someone writes the structure - then we all submit our input to project manager

" ' writes the function - then we all ======================

In this way we know what is being previously said and can follow on....this will be particularly important for the current / ongoing research sections that might become bottle necked here.

The writer of the topic can confer with the group on the discussion page as to what they are writing as they are doing it.

If the writer of the topic disagrees with other group member's ideas the group manager will make a final decision based on a vote.

i dont think it matters who is the group manager but perhaps Sarah is the one for that job (Agree/ Disagree?)

I forward this proposal to the elected project manager and/ or for the group to vote on.


((please comment on ideas of what should be discussed in each topic to give the writer a structure to work with)).

These are my ideas:

1) z3217345 writer: Introduction-Importance of the desmosome in cell biology/who first described the existence of a desmosome? inherited mutations in families first seen / basic necessity of good desmosome function-very brief short description of pathological desmosome function /Structure: location/ histological description/ Em micrographs/ a hand drawn diagram. location of / microscopic appearance which stains are used

2) histological function will be here

3 )z3288729 writer: / abnormalities seen (introduced histologically) factors leading to desmosome pathology is it nutrition based or inherited

4) z3289066 writer: (abnormalities pathology((impact on humans)) leading onto) current research (aims of research/ successes of) what clinical manifestations or symptoms are experienced- the human impact what has research done about it so far

2)+5) z3129413 writer: Histological description of function -introduce the original investigations into desmosome function/ the researchers / due to its structure what is a desmosomes main function includes schematic diagrams and Where research still needs to be done/ any existing problems ( main future investigations of note ). Some sort of conclusion.

writers of topics 1 and 2 will probably have to confer on content.




My name is Sayanthan (Sai) or z3252635 and I'm really sorry I haven't actually said or put up anything on this page. I've read through everything and I'm sort of lost so I was wondering if we could go through the plan in class tommorrow. I've also done a bit of reading up on our topic just background information and sorts so I know what we are talking about. Here are the links i used


Search for MBoC Desmosomes

Article on Desmosomes In Vivo This may be helpful

Wiki Link


--Sayanthan Kumaran 23:38, 30 March 2011 (EST)

Working progress



Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis [1]</pubmed>



Early research on the structure of desmosomes <pubmed>14399189</pubmed> --Sarah Jenkins 10:53, 31 March 2011 (EST)

<pubmed>13845833</pubmed> --Elisabeth Karsten 17:36, 4 April 2011 (EST)




(historical article)






z3129413 (Current research article)







(Review article)





<pubmed>8666164</pubmed> --Elisabeth Karsten 17:41, 4 April 2011 (EST)

<pubmed>16757171</pubmed> --Elisabeth Karsten 18:09, 4 April 2011 (EST)

<pubmed>10367727</pubmed> --Elisabeth Karsten 18:09, 4 April 2011 (EST)

Necessity for functional desmosomes


Desmosomes are important in hyperadhesion, with their structure supporting function, assembly, and regulation. Desmosomes are important in tissue remodelling and are associated with autoimmune and genetic diseases<pubmed>20626351</pubmed> --Sarah Jenkins 10:48, 31 March 2011 (EST)

<pubmed>16303847</pubmed> --Elisabeth Karsten 18:11, 4 April 2011 (EST)



<pubmed>2501314</pubmed> --Elisabeth Karsten 16:38, 4 April 2011 (EST)

<pubmed>12126234</pubmed> --Elisabeth Karsten 16:43, 4 April 2011 (EST)



It is uncertain whether the disorder where desmosomes lose functionality and lead to loss of adhesion between cells, which in turn leaves a blistering effect on the skin, is a genetic, immunological or infectious problem <pubmed>20178467</pubmed> --Sarah Jenkins 10:50, 31 March 2011 (EST)

Abnormalities in the skin and heart have been associated with a lack of plakoglobins and non-functional desmosomes <pubmed>21320868</pubmed> --Sarah Jenkins 09:03, 1 April 2011 (EST)

Dysfunctional desmosomes means that electrical signalling between cardiac myocytes is impaired or lost. This results in arryhtmias, particularly in the right ventricle <pubmed>21360243</pubmed> --Sarah Jenkins 09:05, 1 April 2011 (EST)

Palmoplantar skin is a specialised tissue, whose function is affected by mutant or dysfunctional desmosomes <pubmed>15708285</pubmed> --Sarah Jenkins 14:07, 2 April 2011 (EST)

Research Methods and future research





  1. <pubmed>8608588