Talk:2011 Group 1 Project

From CellBiology
Revision as of 04:22, 26 April 2011 by Z3305561 (talk | contribs)

Post Peer Assessment Discussion

Hey guys in response to the peers i moved around my pictures, gave them text under them, and added a lot of new information and some photos to the structure section. the only issue we have left is to clean up our reference list since it mostly looks like a bunch of pubmed IDs. i guess we will ask mark what to do with this.--Michael Orenstein 21:48, 25 May 2011 (EST)

Week 7

  • This is the week before the mid-session break.
  • In the lab this week we will have an opportunity to discuss any issues which are slowing progress on your project.
  • The Thursday of the week beginning 02 May will be when all projects will be open to Peer Assessment.
  • What you have on your page by Thursday of that week will be the content that others in the class will comment upon.

Week 6

  1. I see many groups now have subsection titles for their projects.
  2. Here are some searches: Pubmed search all databases junction | PLoS junction | JCB junction You can now simply put your own search term into each top window.
  3. Now's the time to get your images, movies, media etc uploaded. Biomed central | JCB | JCB Archive | PLoS. Once uploaded you can make a gallery on either your project or discussion page using <gallery>File:name here</gallery> tags with your image files listed between the tags. When you upload project images, add this text as it appears replacing # with your own Group number to the summary information [[Category:2011Project#]].
  4. Shown below are the criteria that will be used to assess your final project.

Group Assessment Criteria

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.

By Week 5

Each Group member has added to the discussion page:

  1. A Review Article
  2. A Historic Research Article
  3. A Current Research Article

No two students should add the same paper and there should be a link to the original article.

Hey again guys .. I already did my part which is the neurotransmitters (although some of the references are missing .. i will slowly add them up !! Lol ..) please feel free to add or delete anything up there..!! I just realized i will be missing the group meeting .. please update me here of whats going on .. sorry again guys for not being able to attend the meeting .. and if you need my help for anything just post them here .. i promise to check it regularly lol!!! xoxo --Navneet Ahuja 03:49, 26 April 2011 (EST)

hey guys .. i saw that my section is neurotransmitters .. am more than happy to do it !!! I will totally keep in touch and start adding on my parts little by little .. sorry for not being there at todays lab though !! (hope i didnt miss out on alot??) anyways .. just letting you guys know great work with the subheading !!! Laslt, does anyone know if when this is due ? is it still on the 1st of May ? cya soon guys ... !!! xoxo --Navneet Ahuja 12:31, 21 April 2011 (EST)

Ok so those subheadings work;

1) Introduction

2) History? --> although I'm not sure if that's easy to find! however if it's important to be included, why not?

3) what is synaptic Junction? a different pictures

4) types of synaptic junctions! Table is essential + images to demonstrate the difference between types!

5) Neurotransmitters??

6) Synaptic integration

7) Diseases associated with synaptic junctions dysfunctions--> pictures needed!

8) Current and future research and developments ( where it's aimed, potential medical applicaitons)

9) Gallery (pretty much just thumbnails showing a whole lot of images we've come across. Will help ppl with visualizing)

10) Glossary

--Mark Woods 10:43, 21 April 2011 (EST)

Hey Guys,

Let me start by Saying that a Proper meeting would be great to See what parts we are going to write about. Since I find it a little difficult to see comments about neurotransmitters or types of synaptic junctions. I reckon it would be wonderful if we meet up and write the outline of the project for a start. After all, we can get starting with an actual progress! I know all of us want to get a good grade for this subject and get the most out of it! Note: it's essential for the meeting to be prior the holiday :)

What do you guys all think? Sorry for all that, it's my first time doing online project and stuff, so my way is by actual meetings

Oh, and I like the idea of neurotransmitters + synaptic junctions types!

A simple Outline I see commonly is;

1) Introduction

2) History? --> although I'm not sure if that's easy to find! however if it's important to be included, why not?

3) what is synaptic Junction? a different pictures

4) types of synaptic junctions! Table is essential + images to demonstrate the difference between types!

5) Neurotransmitters??

6) Synaptic integration

7) Diseases associated with synaptic junctions dysfunctions--> pictures needed!

8) Future research or developments!

9) Conclusion

Hope that wasn't much for a start!

--z3284061 22:53, 20 April 2011 (EST)

a section on neurotransimmtters is a gud idea, theres plenty in this textbook i got which we can use as a starting point. Also, the book (Principles of Neuroscience 4th edition- Kandel) splits up synaptic junctions as either chemical or electrical. Here is a little from it's intro pages:

Two types of synapse, electricaland chemical. Chemical synaptic junctions have synaptic clefts , electrical synaptic junctions have gap junctions 176.

Electrical distance between pre and post synaptic cell membrances: Electrical is 3.5nm and chemical is 30-40nm.

Electrical transmission is graded and occurs even when the currents in the presynaptic cell are below threshold for an action potential. 178

I think it would be helpful in terms of a starting point to look for additional references, as well as a good reference itself. ALso, we should cover synaptic intergration and modulation by second second messengers. What do you guys think?

I'm also happy with being allocated any subheadings =)

--Mark Woods 20:11, 20 April 2011 (EST)

hey guys --i totally agree with mark that we gotta start splitting up and i think the types of neurotransmitters should also be included somewhere in the page and i am more than happy to do anything u guys assign to me but in particular - i dont mind doing this table thing !! I will be missing thursday lab but of course i will be in touch and like what i said .. i am happy to do anything and i guess we should really get started since the deadline is not very far away .. ?? do u guys think we should do the timeline too ??!! --Navneet Ahuja 00:06, 20 April 2011 (EST)

Okay guys lets start getting some stuff up. So should we divide up the subheadings and each work on one? Some of the sections seem bigger than the others, maybe the Role shud be included in the intro?

--z3254753 21:08, 19 April 2011 (EST)

Hey guys, realised my historic article probably isn't old enough. Here's another one from a fair while back

Pharmacology and Nerve-endings (Walter Ernest Dixon Memorial Lecture): (Section of Therapeutics and Pharmacology)


--Mark Hill 17:02, 30 March 2011 (EST) OK Group 1, No content has been added to either your discussion or project page. You were meant to have already begun looking into both the topic and references, pasting links on your discussion page. I will see you in the lab tomorrow to discuss whether you are having problems or are simply not doing the work. This search should get you started. Search Pubmed: Synaptic Junction

Hey everyone. I was doing some research on our topic but it will be so similar to one of the other pages being done. Have a look yourself before tomorrow and we should make a final decision in the lab if this is what we should do.--Nathan Weller 23:37, 30 March 2011 (EST)

Good Idea, we should make a final decision before we can start posting references. See you guys tomo --z3254753 00:14, 31 March 2011 (EST)

hey guys ... sounds good .. and nathan i think u put the content in the wrong page.. (its in group 2's page) lol .. :) --Navneet Ahuja 09:11, 31 March 2011 (EST)

I think Nathan has done a remarkable Job for a start :)... Well, we can re-adjust it and have a look at the previous projects for more enlightments.. Maqdad Alsaif

Hey guys i did research some articles and here are some of it --Navneet Ahuja 16:12, 2 April 2011 (EST)

1)Synapse Formation in Developing Neural Circuits - general discription on how synapse work !!

Abstract [2]

The nervous system consists of hundreds of billions of neurons interconnected into the functional neural networks that underlie behaviors. The capacity of a neuron to innervate and function within a network is mediated via specialized cell junctions known as synapses. Synapses are macromolecular structures that regulate intercellular communication in the nervous system, and are the main gatekeepers of information flow within neural networks. Where and when synapses form determines the connectivity and functionality of neural networks. Therefore, our knowledge of how synapse formation is regulated is critical to our understanding of the nervous system and how it goes awry in neurological disorders.

Synapse formation involves pairing of the pre- and postsynaptic partners at a specific neurospatial coordinate. The specificity of synapse formation requires the precise execution of multiple developmental events, including cell fate specification, cell migration, axon guidance, dendritic growth, synaptic target selection, and synaptogenesis (Juttner and Rathjen in Cell. Mol. Life Sci. 62:2811, 2005; Salie et al., in Neuron 45:189, 2005; Waites et al., in Annu. Rev. Neurosci. 28:251, 2005). Remarkably, during the development of the vertebrate nervous system, these developmental processes occur almost simultaneously in billions of neurons, resulting in the formation of trillions of synapses. How this remarkable specificity is orchestrated during development is one of the outstanding questions in the field of neurobiology, and the focus of discussion of this chapter.

2) Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias.

Abstract [3]

The most common causes of neurodegenerative dementia include Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). We believe that, in all 3, aggregates of pathogenic proteins are pathological substrates which are associated with a loss of synaptic function/plasticity. The synaptic plasticity relies on the normal integration of glutamate receptors at the postsynaptic density (PSD). The PSD organizes synaptic proteins to mediate the functional and structural plasticity of the excitatory synapse and to maintain synaptic homeostasis. Here, we will discuss the relevant disruption of the protein network at the PSD in these dementias and the accumulation of the pathological changes at the PSD years before clinical symptoms. We suggest that the functional and structural plasticity changes of the PSD may contribute to the loss of molecular homeostasis within the synapse (and contribute to early symptoms) in these dementias.

3)Recent research Early Events of HIV-1 Infection: Can Signaling be the Next Therapeutic Target?

Abstract [4]

Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.


and lastly this article might be helpful to us old neurons


  1. <pubmed>20914505</pubmed>
  2. <pubmed>19427516</pubmed>
  3. <pubmed>20858652</pubmed>
  4. <pubmed>21373988</pubmed>
  5. <pubmed>13278916</pubmed>

Hey guys,

I found I've covered a fair bit of relevant stuff in my lecture notes for another course lol. Maybe they could help us direct our research a bit. Speak more about it in person in the lab :)

here are my research articles;

Gray Matter NG2 Cells Display Multiple Ca-Signaling Pathways and Highly Motile Processes. - current research


The importance of sensory nerve endings as sites of drug action. - review article


Electrophysiologic evidence for an intersegmental reflex pathway between lumbar paraspinal tissues - historical research


--z3254753 12:48, 6 April 2011 (EST)


  1. <pubmed>21455301</pubmed>
  2. <pubmed>1099463</pubmed>
  3. <pubmed>11805709</pubmed>

--z3254753 23:55, 5 April 2011 (EST) Hello Team,

After searching for a while, I came up with these related Articles--z3284061 20:35, 6 April 2011 (EST):

Historic Article:

Morphological changes in the neuritic growth cone and target neuron during synaptic junction development in culture


Current Research:

Turnover of synapse and dynamic nature of synaptic molecules in vitro and in vivo.



Synaptic next term structure and function: Dynamic organization yields architectural precision

*Note: Since this Article is not from Pubmed, I've added an external link.


  1. <pubmed>173724</pubmed>
  2. <pubmed>21448313</pubmed>

--Nathan Weller 00:24, 7 April 2011 (EST)

Review article:

To build a synapse: signaling pathways in neuromuscular junction assembly

Historical article:

Electron microscopy of the cerebral cortex. I. The ultrastructure and histochemistry of synaptic junctions.

Current article:

Ca2+ signaling in the regulation of dendritic cell functions.


Review article

To build a synapse: signaling pathways in neuromuscular junction assembly, Haitao Wu, Wen C. Xiong and Lin Mei*, doi: 10.1242/dev.038711 April 1, 2010 Development 137, 1017-1033. article link

Historical article

Electron microscopy of the cerebral cortex. I. The ultrastructure and histochemistry of synaptic junctions,DE LORENZO AJ., Bull Johns Hopkins Hosp. 1961 Apr;108:258-79. [1]

Current article

Ca2+ signaling in the regulation of dendritic cell functions, Am J Physiol Cell Physiol. 2011 Mar 30, Shumilina E, Huber SM, Lang F. University of Tuebingen.