Talk:2009 Lecture 21

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Developmental Models What makes one cell different from the next? Developmental Models drosophila- fruit fly c. elegans- worm xenopus- frog zebrafish- fish chicken- bird mouse- mammal Background to Patterning All cells contain the same genetic material and are initially equipotent Development is about pattern formation axis and tissue formation Regulators of pattern - signaling Contact (cell-cell, cell-ECM, surfaces) Morphogen (soluble, modified) Time “window”, undifferentiated/differentiated, stem Genome modification, regulators Drosophila Development Model Position-Specific Patterning Cascade of short range inductions Secretion of long range signal Long range secondary signal from primary inductive spinal cord /neural crest, examples of complex structure generated by such a signalling process

Short Range Inductive Cascade Long Range Signal Long Range Secondary Signal from Primary Inductive