Difference between revisions of "Talk:2009 Lecture 21"

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Developmental Models
 
What makes one cell different from the next?
 
Developmental Models
 
drosophila- fruit fly
 
c. elegans- worm
 
xenopus- frog
 
zebrafish- fish
 
chicken- bird
 
mouse- mammal
 
Background to Patterning
 
All cells contain the same genetic material and are initially equipotent
 
Development is about pattern formation
 
axis and tissue formation
 
Regulators of pattern - signaling
 
Contact (cell-cell, cell-ECM, surfaces)
 
Morphogen (soluble, modified)
 
Time
 
“window”, undifferentiated/differentiated, stem
 
Genome modification, regulators
 
Drosophila Development Model
 
Position-Specific Patterning
 
Cascade of short range inductions
 
Secretion of long range signal
 
Long range secondary signal from primary inductive
 
spinal cord /neural crest, examples of complex structure generated by such a signalling process
 
 
Short Range Inductive Cascade
 
Long Range Signal
 
Long Range Secondary Signal from Primary Inductive
 

Latest revision as of 10:12, 2 June 2009