Talk:2009 Group 8 Project

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--Mark Hill 13:43, 19 March 2009 (EST) Adjusted your title format and moved your microscopy information to the discussion page (here). Note, only single square bracket for external links.

microscopy services offered at SOMS UNSW: [1]

--Bridget Josephs 20:01, 29 March 2009 (EST)Hi all just posting a timeline of the necrosis process that we can start working from:


Chronology of the pathologic process of necrosis

· Necrotic insult initiating the irreversible cell death eg - ischemic injury - chemical (toxic) injury

In general:

Macroscopic (visible) level:

0-24hrs: necrotic tissue undergoes a colour change and becomes firm (note however that this does not include necrotic tissue within the brain)
2-3 days: a border demarcated by an inflammatory response can be observed. A fibrinous exudate may additionally be observed
> 1week: healing by fibrosis begins to take place: observe a grey/white periphery zone
After several months: fibrous scar


Microscopic level:

Observation of an acute inflammatory infiltrate in the effected tissue (vasodilation of blood vessels, neutrophils predominating in early stages and later replaced by macrophages, edema etc)
2-3 days: vascular granulation
1 week: fibrous granulation tissue
Months: fibrosis

· Consequence: death of the affected tissue. Sometimes this can result in the death and loss of function of an entire organ

Thanks Bridget! Since our group meeting today fell through lol, we decided it was probably best to post on to this discussion board what proteins we're interested in doing for our individual projects and also which parts of the group project we're keen to do. But we can discuss this more tomorrow during the lab.