Talk:2009 Group 8 Project

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Revision as of 19:01, 29 March 2009 by Z3219393 (talk | contribs)

--Mark Hill 13:43, 19 March 2009 (EST) Adjusted your title format and moved your microscopy information to the discussion page (here). Note, only single square bracket for external links.

microscopy services offered at SOMS UNSW: [1]

--Bridget Josephs 20:01, 29 March 2009 (EST)Hi all just posting a timeline of the necrosis process that we can start working from:

Chronology of the pathologic process of necrosis

· Necrotic insult initiating the irreversible cell death eg - ischemic injury - chemical (toxic) injury

In general:

[[· Macroscopic (visible) level:]] - 0-24hrs: necrotic tissue undergoes a colour change and becomes firm (note however that this does not include necrotic tissue within the brain)

- 2-3 days: a border demarcated by an inflammatory response can be observed. A fibrinous exudate may additionally be observed - > 1week: healing by fibrosis begins to take place: observe a grey/white periphery zone - After several months: fibrous scar

[[· Microscopic level:]]

- Observation of an acute inflammatory infiltrate in the effected tissue (vasodilation of blood vessels, neutrophils predominating in early stages and later replaced by macrophages, edema etc) - 2-3 days: vascular granulation - 1 week: fibrous granulation tissue - Months: fibrosis

· Consequence: death of the affected tissue. Sometimes this can result in the death and loss of function of an entire organ