Difference between revisions of "Stem Cells 2"

From CellBiology
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* Easily available - human embryos from fertility clinics.
 
* Easily available - human embryos from fertility clinics.
  
===Embryonic Stem Cell Dis advantages===
+
===Embryonic Stem Cell Disadvantages===
 
* Unstable - difficult to control differentiation into specific cell type.
 
* Unstable - difficult to control differentiation into specific cell type.
* Immunogenic - potential immuno rejection when transplanted into patients.
+
* Immunogenic - potential immune rejection when transplanted into patients.
 
* Teratomas - tumor composed of tissues from 3 embryonic germ layers.
 
* Teratomas - tumor composed of tissues from 3 embryonic germ layers.
 
* Ethical Controversy - unethical for those who believes that life begins at conception.
 
* Ethical Controversy - unethical for those who believes that life begins at conception.
 +
 +
 +
===Adult Stem Cell Advantages===
 +
 +
* Already ‘specialised’ - induction of differentiation into specific cell types will be easier.
 +
* Plasticity - Recent evidences suggest wider than previously thought ranges of tissue types can be derived.
 +
* No Immune-rejection - if used in autologous transplantations.
 +
* No Teratomas - unlike ES cells.
 +
* No Ethical Controversy - sourced from adult tissues.
 +
 +
===Adult Stem Cell Disadvantages===
 +
* Minimal quantity - number of isolatable cells may be small.
 +
* Finite life-span - may have limited lifespan in culture.
 +
* Ageing - stem cells from aged individuals may have higher chance of genetic damage due to ageing.
 +
* Immunogenic - potential immune rejection if donor cells are derived from another individual.
  
 
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Revision as of 09:11, 23 May 2011

ANAT3231 Cell Biology online lectures from the 2017 course.


Embryonic vs Adult Stem Cells

Embryonic Stem Cell Advantages

  • Pluripotency - ability to differentiateinto any cell type.
  • Immortal - one cell can supply endless amounts of cells.
  • Easily available - human embryos from fertility clinics.

Embryonic Stem Cell Disadvantages

  • Unstable - difficult to control differentiation into specific cell type.
  • Immunogenic - potential immune rejection when transplanted into patients.
  • Teratomas - tumor composed of tissues from 3 embryonic germ layers.
  • Ethical Controversy - unethical for those who believes that life begins at conception.


Adult Stem Cell Advantages

  • Already ‘specialised’ - induction of differentiation into specific cell types will be easier.
  • Plasticity - Recent evidences suggest wider than previously thought ranges of tissue types can be derived.
  • No Immune-rejection - if used in autologous transplantations.
  • No Teratomas - unlike ES cells.
  • No Ethical Controversy - sourced from adult tissues.

Adult Stem Cell Disadvantages

  • Minimal quantity - number of isolatable cells may be small.
  • Finite life-span - may have limited lifespan in culture.
  • Ageing - stem cells from aged individuals may have higher chance of genetic damage due to ageing.
  • Immunogenic - potential immune rejection if donor cells are derived from another individual.

2012 Course Content

Lectures: Cell Biology Introduction | Cells Eukaryotes and Prokaryotes | Cell Membranes and Compartments | Cell Nucleus | Cell Export - Exocytosis | Cell Import - Endocytosis | Cell Mitochondria | Cell Junctions | Cytoskeleton Introduction | Cytoskeleton - Intermediate Filaments | Cytoskeleton - Microfilaments | Cytoskeleton - Microtubules | Extracellular Matrix 1 | Extracellular Matrix 2 | Cell Cycle | Cell Division | Cell Death 1 | Cell Death 2 | Signal 1 | Signal 2 | Stem Cells 1 | Stem Cells 2 | 2012 Revision | Development


Laboratories: Introduction to Lab | Microscopy Methods | Preparation/Fixation | Immunochemistry | Cell Knockout Methods | Cytoskeleton Exercise | Confocal Microscopy | Microarray Visit | Tissue Culture 1 | Tissue Culture 2 | Stem Cells Lab | Stem Cells Analysis



2012 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8 | Group 9

Dr Mark Hill 2015, UNSW Cell Biology - UNSW CRICOS Provider Code No. 00098G