Protein - Caspase 3

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Introduction

  • early event that occurs concomitantly with the onset of apoptosis is the proteolytic breakdown of poly(ADP-ribose) polymerase by a protease with properties resembling those of caspase-1.
  • resulting cleavage (between asp216 and gly217) separates the N-terminal DNA-nick sensor of PARP from its C-terminal catalytic domain.

(From OMIM)

Extrinsic and Intrinsic pathways to caspase-3 activation


Links: Lecture - Cell Death

Antibodies

abcam (AUS Distributor - Sapphire Bioscience)

Cell Signaling

Millipore

Databases

References

Recent References



Reviews

<pubmed>22233886</pubmed>

Search Pubmed

Search Pubmed: Caspase 3 | Cleaved Caspase 3 | All databases

Search OMIM: Caspase 3

External Links

OMIM

Search OMIM: Caspase 3

IMDB