Diagram depicting some of the dynamic processes shared by Trk receptors. Multiple transduction pathways are employed to illicit specific responses regulating survival and differentiation. The end point of signal transduction is often gene regulation and may involve Calcium second messenger events to preciptate expressor/repressor protein dissociation/association from promoter regions. It is important to note that, although phosphorylation is an important event in signal transduction, manny signalling pathways employed by Trk's also utilize allosteric modulation to facilitate binding or oncoupling of signal transduction proteins.
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