File:ZFamilial Adenomatous Polyposis.jpg
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Familial Adenomatous Polyposis (FAP)
Familial Adenomatous Polyposis is a hereditary cancer syndrome caused by a germline APC mutation whereby one defective allele is inherited.  The effect is large numbers of adenomas or polyps (benign out growths) are developed in the colorectum [see picture b].  Inevitably, some of these polyps progress into cancers (CRC) [see picture b and c].
Original text and file name:
"Figure 2 (a) Image showing the entire colon of the third-generation Familial Adenomatous Polyposis (FAP) patient, which was removed by Abdomino Perineal Resection (APR) Method. (b) Image showing the inner lining of the colon, revealing hundreds of polyps all over the surface of the colon and a rosette-shaped malignant tumor at the transverse section of the colon. (c) A close-up of the rosette-shaped malignancy of the colon. The tumor was classified as T4N2M1. Histopathology revealed the tumor to be poorly-differentiated adenocarcinoma."
Indian J Hum Genet. 2009 Sep-Dec; 15(3): 143–144. doi: 10.4103/0971-6866.60192
Copyright © Indian Journal of Human Genetics
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|current||04:16, 13 May 2012||797 × 269 (185 KB)||Z3289738||Figure 2 (a) Image showing the entire colon of the third-generation Familial Adenomatous Polyposis (FAP) patient, which was removed by Abdomino Perineal Resection (APR) Method. (b) Image showing the inner lining of the colon, revealing hundreds of polyps|