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Latest revision as of 21:05, 17 May 2016
Underlying mechanisms in mast cell myositis in asthma
The mechanisms leading to an infiltration in of the airway smooth muscle (ASM) layer by mast cells in asthma firstly involves mast cell chemotaxis towards the ASM bundle, followed by direct mast cell-ASM call adhesion. The mast cell- extracellular matrix adheres to the ASM cell, leading to mast cell activation. Once this occurs, mast cells release mediators which in turn activate ASM cells such as TNF-α and tryptase. ASM cells then produce and secrete chemotactic factors for mast cells, thus leading to an auto-activation loop. Under the influence of Th1, Th2 and/ or pro-inflammatory cytokine stimulation, ASM cells also secrete a range of mast cell chemotactic factors.
<pubmed> PMC3246780 </pubmed>
Copyright © 2011 Annaïg Ozier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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