File:Transendothelial Migration of Eosinophils.jpg
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Multistep process of eosinophil trafficking
Figure 1 Circulating leukocytes initially tether and roll on endothelium via selectins and α4β1 integrin, followed by firm adhesion to endothelium via β1 and β2 integrins, and subsequent extravasation between endothelial cells. Cell adhesion-based therapeutic strategies specifically target adhesion molecules. For example, bimosiamose, a selectin antagonist, blocks the recruitment of eosinophils mediated by E-selectin. The antihistamine levocabastine, several small antagonists, and the monoclonal antibody natalizumab can interfere with the interaction between α4β1 integrin and VCAM-1, while efalizumab and levocabastine can affect αLβ2/ICAM-mediated adhesion.
Copyright © 2012 Baiula, Bedini, Carbonari, Dattoli and Spampinato.
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|current||22:30, 18 May 2016||756 × 331 (90 KB)||Z3414546||==Multistep process of eosinophil trafficking== [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530033/figure/F1/ Figure 1] Circulating leukocytes initially tether and roll on endothelium via selectins and α4β1 integrin, followed by firm adhesion to e...|