File:Transendothelial Migration of Eosinophils.jpg

From CellBiology
Revision as of 22:30, 18 May 2016 by Z3414546 (talk | contribs) (==Multistep process of eosinophil trafficking== [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530033/figure/F1/ Figure 1] Circulating leukocytes initially tether and roll on endothelium via selectins and α4β1 integrin, followed by firm adhesion to e...)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Transendothelial_Migration_of_Eosinophils.jpg(756 × 331 pixels, file size: 90 KB, MIME type: image/jpeg)

Multistep process of eosinophil trafficking

Figure 1 Circulating leukocytes initially tether and roll on endothelium via selectins and α4β1 integrin, followed by firm adhesion to endothelium via β1 and β2 integrins, and subsequent extravasation between endothelial cells. Cell adhesion-based therapeutic strategies specifically target adhesion molecules. For example, bimosiamose, a selectin antagonist, blocks the recruitment of eosinophils mediated by E-selectin. The antihistamine levocabastine, several small antagonists, and the monoclonal antibody natalizumab can interfere with the interaction between α4β1 integrin and VCAM-1, while efalizumab and levocabastine can affect αLβ2/ICAM-mediated adhesion.

Reference

<pubmed>23271999</pubmed>

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530033/


Copyright

Copyright © 2012 Baiula, Bedini, Carbonari, Dattoli and Spampinato.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Please contact the site coordinator if the uploaded content does not meet the original copyright permission or requirements, for immediate removal.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current22:30, 18 May 2016Thumbnail for version as of 22:30, 18 May 2016756 × 331 (90 KB)Z3414546 (talk | contribs)==Multistep process of eosinophil trafficking== [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530033/figure/F1/ Figure 1] Circulating leukocytes initially tether and roll on endothelium via selectins and α4β1 integrin, followed by firm adhesion to e...

The following 2 pages use this file:

Metadata