File:The early immediate hypersensitivity phase of antigen-induced airway inflammation.jpg
Original file (1,050 × 881 pixels, file size: 318 KB, MIME type: image/jpeg)
Role of mast cells in asthma
Original Image legend
The IgE molecules bound to FceRI molecules on a single mast cell. The binding of IgE to FcεRI αβγγ on mast cells (located in airway tissue) up regulates FcεRI surface expression and causes these cells to respond when later exposed to specific antigens. Furthermore, in mast cells, some IgE molecules can increase cytokine production and survival. Once FcεRI aggregation is induced through the recognition of antigens by at least two IgE molecules bound to adjacent FceRI molecules, mast cells become activated, leading to the initiation of an immediate hypersensitivity response. This involves the secretion of preformed mediators soon after antigen exposure. The mast cells further up regulate the production of many cytokines and growth factors. Minutes after exposure, the mediators lead to bronchoconstriction, vasodilatation and increased mucus production. Mast cell mediators can also contribute to late phase reaction by promoting an increase of circulating leukocytes, which can induce further inflammation and bronchoconstriction in the late phase of asthma.
<pubmed> 3597223 </pubmed>
Copyright Urb, Sheppard. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Please contact the site coordinator if the uploaded content does not meet the original copyright permission or requirements, for immediate removal.
Click on a date/time to view the file as it appeared at that time.
|current||23:02, 1 May 2016||1,050 × 881 (318 KB)||Z5015719||The IgE molecules bound to FceRI molecules on a single mast cell. The binding of IgE to FcεRI αβγγ on mast cells (located in airway tissue) up regulates FcεRI surface expression and causes these cells to respond when later exposed to specific ant...|