Difference between revisions of "File:Steroid hormone receptor signaling.gif"

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Figure 2: Steroid hormone receptor signalling.
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==Steroid hormone receptor signalling==
  
 
Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus. There, the receptor dimerizes, binds specific sequences in the DNA, called Hormone Responsive Elements or HREs, and recruits a number of coregulators that facilitate gene transcription. This latter step can be modulated by receptor antagonists like tamoxifen (T), and cellular signalling pathways. Examples of processes studied using biophysical techniques and discussed in this review include: hormone binding (1), chaperone interaction (2), nuclear translocation (3), receptor dimerization (4), DNA binding (5), putative membrane-bound receptors (6), coregulator recruitment (7), transcription (8), proteasomal degradation (9), modulation by cellular signalling pathways (10), and antagonist resistance (11).
 
Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus. There, the receptor dimerizes, binds specific sequences in the DNA, called Hormone Responsive Elements or HREs, and recruits a number of coregulators that facilitate gene transcription. This latter step can be modulated by receptor antagonists like tamoxifen (T), and cellular signalling pathways. Examples of processes studied using biophysical techniques and discussed in this review include: hormone binding (1), chaperone interaction (2), nuclear translocation (3), receptor dimerization (4), DNA binding (5), putative membrane-bound receptors (6), coregulator recruitment (7), transcription (8), proteasomal degradation (9), modulation by cellular signalling pathways (10), and antagonist resistance (11).
  
http://www.nursa.org/article.cfm?doi=10.1621/nrs.05003
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Figure 2:  http://www.nursa.org/article.cfm?doi=10.1621/nrs.05003
  
 
Nuclear Receptor Signaling (2007) 5, e003.
 
Nuclear Receptor Signaling (2007) 5, e003.

Revision as of 08:41, 17 May 2011

Steroid hormone receptor signalling

Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from heat shock proteins, and translocates to the nucleus. There, the receptor dimerizes, binds specific sequences in the DNA, called Hormone Responsive Elements or HREs, and recruits a number of coregulators that facilitate gene transcription. This latter step can be modulated by receptor antagonists like tamoxifen (T), and cellular signalling pathways. Examples of processes studied using biophysical techniques and discussed in this review include: hormone binding (1), chaperone interaction (2), nuclear translocation (3), receptor dimerization (4), DNA binding (5), putative membrane-bound receptors (6), coregulator recruitment (7), transcription (8), proteasomal degradation (9), modulation by cellular signalling pathways (10), and antagonist resistance (11).

Figure 2: http://www.nursa.org/article.cfm?doi=10.1621/nrs.05003

Nuclear Receptor Signaling (2007) 5, e003. Visualizing the action of steroid hormone receptors in living cells Alexander Griekspoor, Wilbert Zwart, Jacques Neefjes and Rob Michalides

Copyright © 2007, Griekspoor et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.

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current23:45, 18 May 2009Thumbnail for version as of 23:45, 18 May 2009442 × 500 (30 KB)S8600021 (talk | contribs)Figure 2: Steroid hormone receptor signalling. Steroid Hormone Receptors (SHR) act as hormone dependent nuclear transcription factors. Upon entering the cell by passive diffusion, the hormone (H) binds the receptor, which is subsequently released from he

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