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Title: Spindle fibres
This image shows that by increasing the concentration of Op18 reduces the length of the spindle fiber. Op18 is a protein that destabilizes the microtubules.
Journal Title: Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.
Original Image Description: Increasing Op18 concentration decreases spindle length. (A) Proposed barrel model for the meiotic spindle (13). (B–F) Spindles formed in Xenopus laevis egg extract were labeled with 0.2 μM X-rhodamine tubulin and treated with either buffer alone or the indicated concentration of excess recombinant Op18. Following a 15-min incubation after addition of Op18, spindles were fixed and imaged. (Left) Widefield images of labeled tubulin. (Right) Merged images of labeled tubulin (red) and DNA (green). (G) Bar graph reporting the average spindle length of fixed spindles, measured as pole-to-pole distance, at indicated time points and concentrations of recombinant Op18. N = >60 spindles for each time point. Error bars represent one standard deviation. (Scale bar: 10 μm.)
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|current||19:23, 9 April 2013||1,159 × 1,280 (280 KB)||Z3371084||[[F1.large.jpg|300px|thumb|Spindle_fiber)] Title: Spindle fibers This image shows that by increasing the concentration of Op18 reduces the length of the spindle fiber. Op18 is a protein that destabilizes the microtubules. Journal Title: Op18 reveals...|