Original file (1,159 × 1,280 pixels, file size: 280 KB, MIME type: image/jpeg)
Title: Spindle fibres
This image shows that by increasing the concentration of Op18 reduces the length of the spindle fiber. Op18 is a protein that destabilizes the microtubules.
Journal Title: Op18 reveals the contribution of nonkinetochore microtubules to the dynamic organization of the vertebrate meiotic spindle.
Original Image Description: Increasing Op18 concentration decreases spindle length. (A) Proposed barrel model for the meiotic spindle (13). (B–F) Spindles formed in Xenopus laevis egg extract were labeled with 0.2 μM X-rhodamine tubulin and treated with either buffer alone or the indicated concentration of excess recombinant Op18. Following a 15-min incubation after addition of Op18, spindles were fixed and imaged. (Left) Widefield images of labeled tubulin. (Right) Merged images of labeled tubulin (red) and DNA (green). (G) Bar graph reporting the average spindle length of fixed spindles, measured as pole-to-pole distance, at indicated time points and concentrations of recombinant Op18. N = >60 spindles for each time point. Error bars represent one standard deviation. (Scale bar: 10 μm.)
Beginning with articles submitted in Volume 106 (2009) the author(s) retains copyright to individual articles, and the National Academy of Sciences of the United States of America retains an exclusive license to publish these articles and holds copyright to the collective work. Volumes 90–105 copyright © (1993–2008) by the National Academy of Sciences. Volumes 1–89 (1915–1992), the author(s) retains copyright to individual articles, and the National Academy of Sciences holds copyright to the collective work.
- Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Please contact the site coordinator if the uploaded content does not meet the original copyright permission or requirements, for immediate removal.
Click on a date/time to view the file as it appeared at that time.
|current||18:23, 9 April 2013||1,159 × 1,280 (280 KB)||Z3371084||[[F1.large.jpg|300px|thumb|Spindle_fiber)] Title: Spindle fibers This image shows that by increasing the concentration of Op18 reduces the length of the spindle fiber. Op18 is a protein that destabilizes the microtubules. Journal Title: Op18 reveals...|