Difference between revisions of "File:Signalling of beta-cell.JPG"

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==Title==
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==Diagrammatic Representation of Beta Cell Intracellaular Signalling==
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In pancreatic beta cells, an increase in blood glucose levels blocks ATP-dependent potassium channels (seen in yellow in image on the right) thus leading to the depolarisation of the membrane. ATP-sensitive potassium channels are potassium channels that are inhibited by high intracellular concentrations of ATP. This depolarisation triggers voltage dependant calcium channels (seen in blue in image on the right) in the membrane to open, causing a calcium influx within the cell. This influx acts on exocytotic machinery, stimulating merging of vesicles containing insulin; preparing them for secretion.
  
 
===Reference===
 
===Reference===
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====Copyright====
 
====Copyright====
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Copyright: © 2006 MacDonald and Rorsman.  
 
Copyright: © 2006 MacDonald and Rorsman.  
  

Latest revision as of 19:17, 26 May 2017

Diagrammatic Representation of Beta Cell Intracellaular Signalling

In pancreatic beta cells, an increase in blood glucose levels blocks ATP-dependent potassium channels (seen in yellow in image on the right) thus leading to the depolarisation of the membrane. ATP-sensitive potassium channels are potassium channels that are inhibited by high intracellular concentrations of ATP. This depolarisation triggers voltage dependant calcium channels (seen in blue in image on the right) in the membrane to open, causing a calcium influx within the cell. This influx acts on exocytotic machinery, stimulating merging of vesicles containing insulin; preparing them for secretion.

Reference

<pubmed>16464129</pubmed>

Copyright

Copyright: © 2006 MacDonald and Rorsman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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current09:24, 26 May 2017Thumbnail for version as of 09:24, 26 May 2017799 × 288 (47 KB)Z5076777 (talk | contribs)==Title== caption ===Reference=== <pubmed>16464129</pubmed> ====Copyright==== Copyright: © 2006 MacDonald and Rorsman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestrict...

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