Proposed_model.jpg (691 × 283 pixels, file size: 59 KB, MIME type: image/jpeg)
Original File Name: Cam-7-142-g3.jpg
Figure Legend: Proposed model of LM-511 expression and function during cancer progression and metastasis.
Web Address: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544778/
Paper Title: Laminin-511 - A multi-functional adhesion protein regulating cell migration, tumor invasion and metastasis
Brief Comment: (1) The tissue organisation is disrupted as a result of the loss of LM - 111 and LM - 332, uncontrolled growth of the tumor and continued expression of LM - 511, exposing the tumor to the surrounding stroma. (2) All the tumor cells undergo the epithelial to mesenchymal transition, under the influence of stromal factors, losing cell - cell contacts. (3) Tumor cell attachment and intravasation is supported by the increased LM - 511 amounts and overall changes in tumor vasculature LM isoforms. (4) Invasion of tumor cells into metastatic sites is supported through integrin and laminin interaction. When these integrins bind with laminin, tumor cells survive and grow.
Copyright: This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
- Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Please contact the site coordinator if the uploaded content does not meet the original copyright permission or requirements, for immediate removal.
Click on a date/time to view the file as it appeared at that time.
|current||22:55, 16 April 2015||691 × 283 (59 KB)||Z3461763||Original File Name: Cam-7-142-g3.jpg Figure Legend: Proposed model of LM-511 expression and function during cancer progression and metastasis. Web Address: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544778/ Paper Title: Laminin-511 - A multi-funct...|