File:Prokaryotic and eukaryotic cytoskeleton 01.jpg
Original file (1,280 × 1,037 pixels, file size: 241 KB, MIME type: image/jpeg)
Homology between prokaryotic and eukaryotic cytoskeletal filaments
Despite low levels of sequence similarity, the homologous cytoskeletal proteins have considerable conservation of folding and also longitudinal interaction.
- Top - FtsZ/TubZ - tubulin (microtubules)
- Bottom - MreB/ParM - actin (microfilaments)
ParM and actin form similar helical filaments, but with opposite chirality (Orlova et al., 2007).
Structures of filament subunits are derived from the following Protein Data Bank accession numbers: 1W5A (FtsZ; Oliva et al., 2004), 1JFF (α/β-tubulin; Löwe et al., 2001), 1JCG (MreB; van den Ent et al., 2001), and 1YAG (actin; Vorobiev et al., 2003).
Rockefeller University Press Copyright Policy This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
Click on a date/time to view the file as it appeared at that time.
|current||20:44, 6 March 2012||1,280 × 1,037 (241 KB)||Z8600021||==Homology between prokaryotic and eukaryotic cytoskeletal filaments== Despite low levels of sequence similarity, the homologous cytoskeletal proteins FtsZ/TubZ/tubulin (top) and MreB/ParM/actin (bottom) have considerable conservation of folding and also|