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Homology between prokaryotic and eukaryotic cytoskeletal filaments

Despite low levels of sequence similarity, the homologous cytoskeletal proteins have considerable conservation of folding and also longitudinal interaction.

  • Top - FtsZ/TubZ - tubulin (microtubules)
  • Bottom - MreB/ParM - actin (microfilaments)

ParM and actin form similar helical filaments, but with opposite chirality (Orlova et al., 2007).

Structures of filament subunits are derived from the following Protein Data Bank accession numbers: 1W5A (FtsZ; Oliva et al., 2004), 1JFF (α/β-tubulin; Löwe et al., 2001), 1JCG (MreB; van den Ent et al., 2001), and 1YAG (actin; Vorobiev et al., 2003).


Reference

<pubmed>21859859</pubmed>| JCB



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current19:44, 6 March 2012Thumbnail for version as of 19:44, 6 March 20121,280 × 1,037 (241 KB)Z8600021 (talk | contribs)==Homology between prokaryotic and eukaryotic cytoskeletal filaments== Despite low levels of sequence similarity, the homologous cytoskeletal proteins FtsZ/TubZ/tubulin (top) and MreB/ParM/actin (bottom) have considerable conservation of folding and also
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