File:Nuclear proteins during mitosis.jpg

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Dynamics of Integral Membrane Protein of the NE

Original file name: JCB.14511f6.jpg

This is a schematic diagram showing what happens to the integral membrane proteins of the nuclear envelope before, during and after mitosis. The top image shows the nuclear envelope during interphase, with the outer nuclear membrane being continuous with the endoplasmic reticulum (ER) and the inner nuclear membrane containing integral membrane proteins which may be bound to lamins or chromatin. The middle image depicts the dispersion of the integral membrane proteins throughout the ER membranes after the nuclear envelope has broken down during metaphase/prometaphase The bottom image shows the return of the integral membrane proteins to the newly reformed NE during late anaphase. This is proposed to occur by diffusion through the ER. --Z3331556 (talk) 19:09, 28 May 2013 (EST)

Original legend: Model depicting the dynamics of integral membrane proteins of the NE during mitosis. The interphase NE is morphologically continuous with the peripheral ER but is a specialized ER subcompartment that contains integral membrane proteins specific to the inner nuclear membrane (top) and nuclear pore membrane (not shown). Integral proteins of the inner nuclear membrane may be bound to lamins, lamina-associated proteins, or chromatin. During mitosis when the NE is disassembled, integral membrane proteins of the NE are dispersed throughout all ER membranes, and the NE loses its identity as an ER subcompartment (middle). We propose that integral proteins are resorted to the NE during late anaphase by diffusion through a functionally continuous ER and subsequent association with binding sites at the chromosomes (bottom). The binding sites for inner membrane proteins may include lamins and chromatin (bottom); those for nuclear pore membrane proteins may include other pore complex components (not shown). These binding interactions would result in the net collection of nuclear membrane proteins at the reforming NE (bottom, arrows). Reformation of the NE may involve cooperative assembly of lamins and integral membrane proteins of the inner nuclear membrane (bottom).



Integral Membrane Proteins of the Nuclear Envelope Are Dispersed throughout the Endoplasmic Reticulum during Mitosis


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current18:40, 28 May 2013Thumbnail for version as of 18:40, 28 May 2013597 × 1,199 (180 KB)Z3331556 (talk | contribs)Original file name: JCB.14511f6.jpg Integral Membrane Proteins of the Nuclear Envelope Are Dispersed throughout the Endoplasmic Reticulum during Mitosis Model depicti...

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