File:Nuclear envelope during mitosis.jpg

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Nuclear Envelope Breakdown and Reassembly

Original file name: 1423-0127-16-96-3.jpg

This schematic image depicts the changes that the nuclear envelope goes through during mitosis. It shows the nuclear envelope breakdown and the consequent loss of NE-associated proteins during prophase. It also shows the reformation of the nuclear envelope and nuclear lamins around the condensed chromatin during anaphase and telophase respectively. --Z3331556 (talk) 16:29, 7 April 2013 (EST)

Original legend: Nuclear envelope breakdown and reassembly in mitosis. At the end of G2, the activation of cyclin-dependent kinases, including CDK1, triggers entry into mitotic prophase. The nuclear membrane breaks down, and the NE-associate proteins either translocate to kinetochores, distribute with the fragmented ER networks, or dissolve in the cytoplasm. During NE reassembly in anaphase, SUN1 and LAP2 first appear around the condensed chromatin, though at different regions. The nuclear lamins then join the nuclear periphery in telophase. This figure illustrates the important roles played by the NE and the nuclear lamina in normal mitosis.



The nuclear envelopathies and human diseases


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current15:51, 7 April 2013Thumbnail for version as of 15:51, 7 April 2013600 × 395 (50 KB)Z3331556 (talk | contribs)Original file name: 1423-0127-16-96-3.jpg The nuclear envelopathies and human diseases Nuclear envelope breakdown and reassembly in mitosis. At the end of G2, the activation of cyclin-dependent ki...

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