File:Nuclear envelope and its proteins.jpg

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The Nuclear Envelope and its proteins

Original file name: 1423-0127-16-96-1.jpg

This image is a schematic drawing of the Nuclear Envelope (NE) showing its composite structures including the outer and inner nuclear membranes and NE proteins and their associations with surrounding nuclear and cytoplasmic elements including the lamina, microtubules and actin. It particularly depicts the three-layers of NE proteins which include the nuclear pore complex (NPC) that spans both membranes and inner nuclear membrane proteins (SUN1, LAP2, Emerin, MAN1 and LBR)that interact with the underlying lamina. It can be seen that the outer nuclear membrane is continuous with the endoplasmic reticulum (ER) and the space between the two nuclear membranes open up to the perinuclear space of the ER --Z3331556 (talk) 12:15, 7 April 2013 (EST)

Original legend: The three-layers of NE proteins. The nuclear pore complex (NPC) transverses the inner and outer nuclear membranes. INM proteins, including SUN1, LAP2, Emerin, MAN1 and LBR, are mostly associated with the nuclear lamina. Emerin, LAP2 and MAN1 harbor a LEM domain which interacts with BAF (barrier-to-autointegration factor), a chromatin-binding protein. The nuclear lamina forms a meshwork underlying the inner nuclear membrane.



The nuclear envelopathies and human diseases


Copyright ©2009 Chi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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current12:10, 7 April 2013Thumbnail for version as of 12:10, 7 April 2013600 × 361 (56 KB)Z3331556 (talk | contribs)Original file name: 1423-0127-16-96-1.jpg The nuclear envelopathies and human diseases The three-layers of NE proteins. The nuclear pore complex (NPC) transverses the inner and outer nuclear membr...

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