File:Neuron necrosis apoptosis.jpg

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Two Electron Micrograph Images of Neuronal Death

Figure 3. ProTα induced cell death mode switch. (b)

Transmission EM analysis at 12 h. Necrosis is characterized by membrane destruction and loss of electron density in the cytosol. Apoptotic features of nuclear fragmentation, but no substantial necrotic features, are observed in neurons treated with 25 pmol/cm2 ProTα or 20% CM. The CM, which had been preabsorbed with α-ProTα IgG, shows no apoptosis induction.

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Reference

Ueda H, Fujita R, Yoshida A, Matsunaga H & Ueda M. (2007). Identification of prothymosin-alpha1, the necrosis-apoptosis switch molecule in cortical neuronal cultures. J. Cell Biol. , 176, 853-62. PMID: 17353361



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current22:50, 11 May 2009Thumbnail for version as of 22:50, 11 May 2009528 × 282 (26 KB)S8600021 (talk | contribs)Two tem images of neuronal death from Figure 3. ProTα induced cell death mode switch. (b) Transmission EM analysis at 12 h. Necrosis is characterized by membrane destruction and loss of electron density in the cytosol. Apoptotic features of nuclear frag