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The Dynamic Membrane Events Involved in Autophagy

(A) Upon induction of autophagy, a membrane sac called the isolation membrane (IM) forms and engulfs portions of the cytoplasm. Sealing of its edges gives rise to the double-membrane bound autophagosome. Fusion of the outer membrane with a lysosome results in formation of an autolysosome, in which the inner autophagosomal membrane and its contents are degraded.

(B) Starvation-induced autophagosomes (AP) and autolysosomes (AL) in the fat body (the functional analogue of the liver) of a fruit fly larva. Note that APs contain intact cytoplasm, whereas the contents of ALs show various stages of degradation.

(C) Liver cells of starved mice carrying a fluorescently tagged LC3 transgene, labeling cup-shaped and ring-shaped structures that correspond to IMs and autophagosomes, respectively. Images courtesy of Ryan Scott (B) and Dr. Noboru Mizushima (C).

doi:10.1371/journal.pbio.0040036.g001

Figure 1.


Citation: Juhasz G, Neufeld TP (2006) Autophagy: A Forty-Year Search for a Missing Membrane Source. PLoS Biol 4(2): e36. doi:10.1371/journal.pbio.0040036

http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0040036

Published: February 14, 2006

Copyright: © 2006 Juhasz and Neufeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in ay medium, provided the original author and source are credited.

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