File:Membrane events involved in autophagy.jpg
Original file (736 × 1,000 pixels, file size: 153 KB, MIME type: image/jpeg)
The Dynamic Membrane Events Involved in Autophagy
(A) Upon induction of autophagy, a membrane sac called the isolation membrane (IM) forms and engulfs portions of the cytoplasm. Sealing of its edges gives rise to the double-membrane bound autophagosome. Fusion of the outer membrane with a lysosome results in formation of an autolysosome, in which the inner autophagosomal membrane and its contents are degraded.
(B) Starvation-induced autophagosomes (AP) and autolysosomes (AL) in the fat body (the functional analogue of the liver) of a fruit fly larva. Note that APs contain intact cytoplasm, whereas the contents of ALs show various stages of degradation.
(C) Liver cells of starved mice carrying a fluorescently tagged LC3 transgene, labeling cup-shaped and ring-shaped structures that correspond to IMs and autophagosomes, respectively. Images courtesy of Ryan Scott (B) and Dr. Noboru Mizushima (C).
Citation: Juhasz G, Neufeld TP (2006) Autophagy: A Forty-Year Search for a Missing Membrane Source. PLoS Biol 4(2): e36. doi:10.1371/journal.pbio.0040036
Published: February 14, 2006
Copyright: © 2006 Juhasz and Neufeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in ay medium, provided the original author and source are credited.
Click on a date/time to view the file as it appeared at that time.
|current||08:04, 10 May 2011||736 × 1,000 (153 KB)||S8600021||==The Dynamic Membrane Events Involved in Autophagy== (A) Upon induction of autophagy, a membrane sac called the isolation membrane (IM) forms and engulfs portions of the cytoplasm. Sealing of its edges gives rise to the double-membrane bound autophagoso|