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Role of MFAP-4 in Elastic fiber assembly
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'''Role of MFAP-4 in Elastic fiber assembly'''
  
 
(a) Secreted MFAP-4 and fibrillin-1 interact directly, resulting in the assembly of microfibrils under normal conditions. Tropoelastins assembled with LOX recruited by fibulin-4 are subsequently cross-linked with microfibrils for the formation of complete mature elastic fibers. (b) In the absence of MFAP-4, fibrillin-1 cannot be assembled or matured for the formation of microfibrils.
 
(a) Secreted MFAP-4 and fibrillin-1 interact directly, resulting in the assembly of microfibrils under normal conditions. Tropoelastins assembled with LOX recruited by fibulin-4 are subsequently cross-linked with microfibrils for the formation of complete mature elastic fibers. (b) In the absence of MFAP-4, fibrillin-1 cannot be assembled or matured for the formation of microfibrils.

Revision as of 18:00, 23 April 2015

Role of MFAP-4 in Elastic fiber assembly

(a) Secreted MFAP-4 and fibrillin-1 interact directly, resulting in the assembly of microfibrils under normal conditions. Tropoelastins assembled with LOX recruited by fibulin-4 are subsequently cross-linked with microfibrils for the formation of complete mature elastic fibers. (b) In the absence of MFAP-4, fibrillin-1 cannot be assembled or matured for the formation of microfibrils.

Reference

<pubmed>PMC3240987</pubmed>

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current17:55, 23 April 2015Thumbnail for version as of 17:55, 23 April 2015946 × 624 (103 KB)Z3374116 (talk | contribs)Role of MFAP-4 in Elastic fiber assembly (a) Secreted MFAP-4 and fibrillin-1 interact directly, resulting in the assembly of microfibrils under normal conditions. Tropoelastins assembled with LOX recruited by fibulin-4 are subsequently cross-linked wi...

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