File:ECM elastic fiber assemby model.jpg

From CellBiology
Revision as of 23:59, 27 April 2009 by S8600021 (talk | contribs)
Original file(1,280 × 852 pixels, file size: 148 KB, MIME type: image/jpeg)

Figure 8. The Line DANCE model.

(A) This model illustrates how fibulin-5/DANCE promotes fibrillar deposition and cross-linking of tropoelastin molecules on microfibrils to promote the development of mature elastic fibers.

(B) Truncated fibulin-5 cannot be deposited on microfibrils, and therefore cannot promote elastic fiber assembly.

fibulin-5 - also called developing arteries and neural crest EGF-like [DANCE] or embryonic vascular EGF-like repeat–containing protein [EVEC] lysyl oxidase (LOX) enzymes cross-link

Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. Hirai M, Ohbayashi T, Horiguchi M, Okawa K, Hagiwara A, Chien KR, Kita T, Nakamura T. J Cell Biol. 2007 Mar 26;176(7):1061-71. Epub 2007 Mar 19. PMID: 17371835


Published online March 19, 2007 doi:10.1083/jcb.200611026

The Journal of Cell Biology, Vol. 176, No. 7, 1061-1071 The Rockefeller University Press, 0021-9525 $30.00 © 2007 Hirai et al.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current23:57, 27 April 2009Thumbnail for version as of 23:57, 27 April 20091,280 × 852 (148 KB)S8600021 (talk | contribs)Figure 8. The Line DANCE model. (A) This model illustrates how fibulin-5/DANCE promotes fibrillar deposition and cross-linking of tropoelastin molecules on microfibrils to promote the development of mature elastic fibers. (B) Truncated fibulin-5 cannot be
  • You cannot overwrite this file.

The following 3 pages uses this file:

Metadata