Difference between revisions of "File:Affect of Good Pasture's Disease on the glomerulus.jpg"
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Revision as of 08:28, 4 June 2015
Affect of Goodpasture's Disease on the glomerulus
Classic Kidney Lesions in Goodpasture’s Disease, and the Immunoreactivity of Circulating and Kidney-Bound Goodpasture Autoantibodies to Six Noncollagenous-1 Domain Monomers of Human Collagen IV. The specimen at left in Panel A (Jones’s silver stain) shows cellular crescents (arrows) and necrosis of glomerular tufts (arrowheads), features of glomerulonephritis mediated by anti–glomerular-basement-membrane (GBM) antibodies; the specimen at right shows a glomerulus with crescent and linear staining of the GBM with fluorescein-labeled antihuman IgG antibody. Panels B, C, and D show the reactivity of serum from a total of 57 patients with Goodpasture’s disease, grouped according to noncollagenous-1 (NC1) specificity. In Panel B, serum samples from 12 patients react only with α3NC1. In Panel C, samples from 12 different patients react with α3NC1 and α5NC1. In Panel D, samples from 33 different patients react with α1NC1, α3NC1, α4NC1, and α5NC1. These findings differed significantly from the findings in serum samples from 18 healthy volunteers, which showed non-reactivity (P<0.05). Panel E shows the binding of autoantibodies eluted from the kidneys of 14 patients with Goodpasture’s disease. Significant binding was detected only to the α3NC1, α5NC1, and α4NC1 domains, with less binding to the last than to the first two (P<0.05). Normal kidney eluates from 3 patients without Goodpasture’s disease were nonreactive with all NC1 domains. In Panels B through E, the circles indicate values in individual patients, the solid horizontal lines indicate medians, and the dotted horizontal lines indicate means plus 3 SD for normal samples.
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|current||08:26, 4 June 2015||725 × 299 (100 KB)||Z3417458||=Affect of Goodpasture's Disease on the glomerulus= This is a histological figure of the glomerulus affected by Goodpasture's Disease and antihuman IgG antibody fluorescein staining. Classic Kidney Lesions in Goodpasture’s Disease, and the Immuno...|