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The activation of cyclin-dependent kinases by Cdc25 phosphatases

The coordinated action of kinases and phosphatases regulates cyclin-dependent kinase (Cdk) activity during cell-cycle progression. (A) Cdks are maintained in an inactive state through the phosphorylation of Thr 14 (T14) and Tyr 15 (Y15) in their amino-terminal ATP-binding regions by members of the Wee1/Mik1/Myt1 protein kinase family. The rate-limiting step in the activation of Cdks is dephosphorylation of these residues by Cdc25 dual-specificity phosphatases. (B) Cdc25A regulation of Cdk2/cyclin E during G1 and S phase. (C) Cdc25A, Cdc25B and Cdc25C regulation of Cdk1/cyclin B during G2 and M phase. Cdc, cell-division cycle; Cyc, cyclin.

References

http://www.nature.com/embor/journal/v4/n7/full/embor887.html

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