--Mark Hill 08:40, 20 March 2009 (EST) This is a working page for developing a quick glossary of cell biology designed for students at undergraduate level. The student group project glossary template is more basic than this current page and is available on this page's discussion tab.
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Cytoskeletal protein forming the backbone of the cytoplasmic microfilament system. Exists as globular actin monomer (G-actin) and microfilament polymer (F-actin). Lecture - Cytoskeleton 3 Microfilaments
Family of proteins that specifically bind actin within microfilament polymer (F-actin) or globular actin monomer (G-actin). Lecture - Cytoskeleton 3 Microfilaments
Actin Depolymerizing Factor
(ADF) alternative name Cofilin, actin-binding protein that can disassemble actin by severing and depolymerizing actin filaments. Lecture - Cytoskeleton 3 Microfilaments
A protein complex essential for actin assembly, generating new filaments and branch points. It is involved in cell motility in many cell processes. Lecture - Cytoskeleton 3 Microfilaments
Structure present outside bacteria and plant cells. Gram-positive bacteria, composed of the cytoplasmic membrane and peptidoglycan layer. Gram-negative bacteria, have an additional outer membrane composed of integral membrane proteins, lipids, and lipopolysaccharides. Lecture - Eukaryotes and Prokaryotes
Cytoplasmic microtubule organizing centre and thought to also regulate cell cycle events. PMID: 18437411
Alternative name Actin Depolymerizing Factor, actin-binding protein that can disassemble actin by severing and depolymerizing actin filaments. Lecture - Cytoskeleton 3 Microfilaments
correlative light/electron microscopy
(CAP) actin-binding protein that works in conjunction with Cofilin.
Dynamin family of GTPases member expressed in the nervous system and involved in many cellular pathways, implicated in clathrin-mediated endocytosis. Lecture - Cell Import - Endocytosis
Dynamin family of GTPases member ubiquitously expressed and involved in many cellular pathways, implicated in clathrin-mediated endocytosis. Lecture - Cell Import - Endocytosis
A microtubule-stabilizing agent isolated from a soft coral (Eleutherobia sp.).
hydrogenosome cytoplasmic anaerobic organelle related to mitochondria adaptated to extreme cellular anaerobic lifestyle. Lecture - Eukaryotes and Prokaryotes |
Cytoskeleton filament system required for cell mechanical stability and integrity. The name comes from the filaments being "intermediate" in cross-sectional size between microfilaments and microtubules. Lecture - Cytoskeleton - Intermediate Filaments
Cytoskeleton intermediate filament protein of epithelial cells required for cell mechanical stability and integrity. Humans have 54 functional keratin genes. Lecture - Cytoskeleton - Intermediate Filaments | PMID: 18461349
A genetically engineered mouse in which genetic information is inserted into a particular locus in the genome. The mouse can now express this inserted gene/protein. Lab - Cell Knockout Methods
A genetically engineered mouse in which genetic information is deleted from a particular locus in the genome. The mouse can now not express this modified or deleted gene and therefore protein. Lab - Cell Knockout Methods
Cytoplasmic phospholipid enclosed depots of neutral lipids found in many cell types. PMID: 18546013
Cytoplasmic organelle for the degradation of both endocytosed extracellular and autophagy of intracellular materials. Lecture - Cell Import - Endocytosis
(MDBs) liver disease associated protein aggregates consisting of ubiquitinated K8/K18, chaperones and sequestosome1/p62 (p62).
(MMPs) secreted family of proteins that can degrade or modify components of the extracellular matrix, cellular receptors, and cytokines. In humans, 24 different MMPs have roles in normal and pathophysiological cellular events. Lecture - Extracellular Matrix
Cytoskeleton filament system required for cell shape and motility. The name comes from the filaments being the smallest in cross-sectional size of the three filament systems including intermediate filaments and microtubules. Lecture - Cytoskeleton 3 Microfilaments
Cytoskeleton filament system required for intracellular transport and motility. The name comes from the system filaments forming "tubes", they are also the largest in cross-sectional size of the three filament systems including microfilaments and intermediate filaments. Lecture - Cytoskeleton 3 Microtubules
Cytoplasmic double membrane organelle, main functions include energy production from aerobic cell respiration and cell death by apoptosis. Lecture - Cell Energy Production - Mitochondria
multivesicular bodies (MVB)
A microtubule-stabilizing agent used in cancer therapy. Originally isolated from the Pacific yew tree (Taxus brevifolia) and called taxol, it is a member of the taxane family.
(cell membrane) The lipid based bilayer forming the container for each cell Lecture - Compartments and Cell Membranes
A protein complex that degrades cellular proteins by proteolysis. Lecture - Cell Import - Endocytosis
(PBs) cytoplasmic plant organelles that accumulate storage proteins in seeds, formed from endoplasmic reticulum or vacuole.
Human severe blistering skin disease caused by autoantibodies against desmosomal cadherins. Lecture - Cytoskeleton - Intermediate Filaments
Family of secreted transmembrane and GPI-linked proteins that alter the cytoskeletal organization of micofilaments and microtubules. Humans have 20 semaphorins, defined by cysteine-rich semaphorin protein domains, expressed in the nervous system and other tissues.
A highly conserved GTPase family found in fungi and animals implicated in a diversity of cellular processes including cytokinesis, formation of diffusion barriers and vesicle trafficking. Septin2 partially co-localises with actin bundles in mammalian interphase cells.
A bacterial protein toxin produced by Shigella dysenteriae is transported directly from the plasma membrane to the endoplasmic reticulum by early endosomes and the Golgi apparatus. Lecture - Cell Import - Endocytosis | PMID: 11514628
(Ub) PMID: 17689064
Wiskott-Aldrich syndrome protein (WASP)
Bacterial protein toxins produced by enterohemorrhagic strains of Escherichia coli these are transported directly from the plasma membrane to the endoplasmic reticulum by early endosomes and the Golgi apparatus. Lecture - Cell Import - Endocytosis | PMID: 11514628