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Lecture Feedback

Lecture 4 - Nucleus

I found "Protein Postcodes" to be an interesting concept; in order for proteins to reach their appropriate sites for post-translational changes to occur, the mRNA is first translated by cytoplasmic ribosomes. The initial amino sequence determines whether the mRNA-Amino-ribsomal complex remains in the cytoplasm or is translocated and becomes fixed in the Rough ER. Normal translation occurs from here using local ribosomes(be they cytoplasmic or reticular) and, in the case of ER translation, Peptide products are ejected from complex into the ER lumen for further post-translational modification.