3187043

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Revision as of 18:58, 12 May 2009 by S8600021 (talk | contribs)

--Mark Hill 18:58, 12 May 2009 (EST)Your individual project (due week 10) needs significant work.

Individual Project

Rb Protein

"previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..."

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract

Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?

Human papillomavirus immortalization and transformation functions