Difference between revisions of "3187043"
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| − | + | '''Retinoblastoma Protein''' | |
| − | + | named from a chidhood cancer where it was first discovered | |
| + | rb inhibits the cell cycle | ||
| + | becomes inactive when it is phosphorylated by protein cyclin-dependent kinases Cdk4 and Cdk2, unblocking and allowing the cell to pass the restriction point in order to progress from the G1 phase into the S phase of the cell cycle. Prior to this crutial step, the activation of Cdk4 and Cdk2 must occur through the synthesis and binding of cyclins D and E to Cdk4 and Cdk2, respectively, which form cyclin-cdk complexes. | ||
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| + | Purves et al. Life The Science Of Biology 7E | ||
"previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..." | "previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..." | ||
Revision as of 16:39, 13 May 2009
Retinoblastoma Protein
named from a chidhood cancer where it was first discovered rb inhibits the cell cycle becomes inactive when it is phosphorylated by protein cyclin-dependent kinases Cdk4 and Cdk2, unblocking and allowing the cell to pass the restriction point in order to progress from the G1 phase into the S phase of the cell cycle. Prior to this crutial step, the activation of Cdk4 and Cdk2 must occur through the synthesis and binding of cyclins D and E to Cdk4 and Cdk2, respectively, which form cyclin-cdk complexes.
Purves et al. Life The Science Of Biology 7E
"previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..."
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract
- "pRb" Entrez all databases
Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?
Human papillomavirus immortalization and transformation functions
