Difference between revisions of "3187043"

From CellBiology
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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract
 
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract
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* "pRb"  [http://www.ncbi.nlm.nih.gov/sites/gquery?itool=toolbar&cmd=search&term=pRb Entrez all databases]

Revision as of 19:47, 2 May 2009

Individual Project

Rb Protein

"previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..."

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract