Difference between revisions of "3187043"

From CellBiology
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Rb Protein
 
Rb Protein
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"previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..."
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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract

Revision as of 19:44, 2 May 2009

Individual Project

Rb Protein

"previous studies indicate that the HCV RNA-dependent RNA polymerase, nonstructural protein 5B (NS5B), forms a complex with the retinoblastoma tumor suppressor protein (pRb), targeting it for degradation, activating E2F-responsive promoters, and stimulating cellular proliferation....the abundance of pRb is strongly downregulated, and its normal nuclear localization altered to include a major cytoplasmic component..."

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323300&tool=pmcentrez&rendertype=abstract