2011 Group 2 Project

From CellBiology

Introduction

Haley

History

Michael

Structure

Michael

Function

Haley

Location

Hadassah

Gap Junctions are located in cardiac muscle and smooth muscle

Comparison with Other Junctions

Hadassah

Comparison of Cell Junctions
Name of Junction Function Location Associated Proteins Diseases Diagram
Tight Junction Form a barrier which holds neighbouring cells together

preventing the mixing of apical and basolateral components helping to maintain cell polarity [1]

Apical junction of epithelial cells and endothelial cells [2] occludin

claudins junction adhesion molecules [3]

Inflammatory Bowel Disease (IBD)

Crohn's Disease and Ulcerative Colitis associated with loss of tight junction [4]

Adherens Junction cadherins

β-catenin or gamma-catenin α-catenin

Desmosomes anchors cells to each other Epethilum and cardiac muscle Cadherin Bullous Impetigo

Palmoplantar Keratoderma

Septate Junctions
Tunneling Nanotubes
Hemidesmosome
Neuromuscular Junction Invloved in communcation and muscle contraction forms between motor neurons and skeletal muscle fibres [5] Myasthenia Gravis

Lambert-Eaton Myasthenic syndrome - defective neurotransmitter release [6]

Diseases Associated with Gap Junctions

Liz

Current Research

Liz

Glossary

Connexin

Connexon

References

  1. <pubmed> 18415116 </pubmed>
  2. <pubmed> 18415116 </pubmed>
  3. <pubmed> 15151915 </pubmed>
  4. <pubmed> 19632896 </pubmed>
  5. <pubmed> 20215342 </pubmed>
  6. <pubmed> 10616683 </pubmed>


2011 Projects: Synaptic Junctions | Gap Junctions | Tight Junctions | Desmosomes | Adherens Junctions | Neuromuscular Junction