Difference between revisions of "2009 Group 4 Project"

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===Structure===
 
===Structure===
TrK receptors act as dimeric transmembrane proteins. Distally, three cysteine-rich motiffs and two Leucine rich regions form conserved NGF binding region which is common to all TrK's near the amino terminus(in addition, Trk A is possesed of an additional NGF binding region, see TrK A).
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TrK receptors act as dimeric transmembrane proteins. Distally, three cysteine-rich motiffs and two Leucine rich regions form a conserved NGF binding region which is common to all TrK's near the amino terminus(in addition, Trk A is possesed of an additional NGF binding region, see TrK A).
 
Additionally, the common binding region is flanked by a pair of extracelluar immunoglobin-like domains located proximally to the cell membrane. The juxtamembrane complex contains a variable amino acid sequence suggested to determine ligand bindng affinity and specificiy and may bind directly to some ligands.
 
Additionally, the common binding region is flanked by a pair of extracelluar immunoglobin-like domains located proximally to the cell membrane. The juxtamembrane complex contains a variable amino acid sequence suggested to determine ligand bindng affinity and specificiy and may bind directly to some ligands.
  

Revision as of 20:32, 23 April 2009

Tropomyosin Receptor Kinases (Trk) Receptors

                                        "Under Construction"


Introduction

Trk receptors are a family of tyrosine kinases commonly associated with growth and function regulation in neuronal cells. Binding of ligands to Trks can effect growth, plasticity and synaptic strength of neuronal junctions - although it is notable that Ligand binding does not itself illicit an action potential event.

Structure

TrK receptors act as dimeric transmembrane proteins. Distally, three cysteine-rich motiffs and two Leucine rich regions form a conserved NGF binding region which is common to all TrK's near the amino terminus(in addition, Trk A is possesed of an additional NGF binding region, see TrK A). Additionally, the common binding region is flanked by a pair of extracelluar immunoglobin-like domains located proximally to the cell membrane. The juxtamembrane complex contains a variable amino acid sequence suggested to determine ligand bindng affinity and specificiy and may bind directly to some ligands.

Function

Dynamic Process

Current Research

Timeline

References

Glossary

2009 Group Projects

--Mark Hill 14:02, 19 March 2009 (EST) Please leave these links to all group projects at the bottom of your project page.

Group 1 Meiosis | Group 2 Cell Death - Apoptosis | Group 3 Cell Division | Group 4 Trk Receptors | Group 5 The Cell Cycle | Group 6 Golgi Apparatus | Group 7 Mitochondria | Group 8 Cell Death - Necrosis | Group 9 Nucleus | Group 10 Cell Shape