- 1 Lab Attendance
- 2 Individual Assessments
- 3 Peer Review
- 4 Project Page
- 5 Work Area
- 6 References
--Elisabeth Karsten 10:42, 10 March 2011 (EST)
--Elisabeth Karsten 09:03, 17 March 2011 (EST)
--Elisabeth Karsten 09:10, 24 March 2011 (EST)
--Elisabeth Karsten 08:49, 31 March 2011 (EST)
--Elisabeth Karsten 08:40, 7 April 2011 (EST)
--Elisabeth Karsten 09:01, 14 April 2011 (EST)
--Elisabeth Karsten 08:40, 21 April 2011 (EST)
--Elisabeth Karsten 09:25, 5 May 2011 (EST)
--Elisabeth Karsten 09:49, 12 May 2011 (EST)
--Elisabeth Karsten 08:58, 19 May 2011 (EST)
--Elisabeth Karsten 09:12, 26 May 2011 (EST)
--Elisabeth Karsten 08:43, 2 June 2011 (EST)
1. What are the key cell biology journals?
- The Journal of Cell Biology
- BMC Cell Biology
- Nature Cell Biology
- PLoS Biology
2. Which Journals allow reuse of their published content
- The Journal of Cell Biology
- BMC Cell Biology
- Public Library of Science
1. Which chromosomes contribute to the nucleolus?
The nucleolus is the site of ribosomal (rRNA) gene transcription, processing, and ribosomal assembly. Chromosomes 13, 14, 15, 21, 22 contain clusters of rRNA genes that contribute to the nucleolus and its function.
2. Identify and add a link to your page of a recent cell biology article using confocal microscopy.
1. Find the SDS information for Chloroform and identify the hazards associated with this chemical.
Biological Limit Values
- No biological limit allocated.
- Avoid inhalation. Use in well ventilated areas. Where an inhalation risk exists, mechanical extraction ventilation is recommended.
- S6 - Classified as a Schedule 6 (S6) Poison using the criteria in the Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP).
- Wear splash-proof goggles, viton (R) or PVA gloves and coveralls. Where an inhalation risk exists, wear: a Type A (Organic vapour) respirator. At high vapour levels, wear: an Air-line respirator.
Health Hazard Summary
- Toxic - irritant. This product has the potential to cause adverse health effects. Use safe work practices to avoid eye or skin contact and inhalation. Over exposure may result in nerve, liver, kidney and lung damage. Central nervous system and cardiac depressant. Experimental teratogen. Chloroform is classified as possibly carcinogenic to humans (IARC Group 2B).
- Irritant. Contact may result in irritation, lacrimation, pain, redness and conjunctivitis. May result in burns with prolonged contact.
- Toxic - irritant. Over exposure may result in irritation of the nose and throat, coughing, nausea, headache, fatigue, loss of appetite and vomiting. High level exposure may result in dizziness, breathing difficulties, pulmonary oedema and unconsciousness.
- Irritant. Contact may result in drying and defatting of the skin, rash and dermatitis. May be absorbed through skin with harmful effects.
- Toxic. Ingestion may result in nausea, vomiting, abdominal pain, dizziness, fatigue and diarrhoea. Ingestion of large quantities may result in liver and kidney damage, and unconsciousness. Aspiration may result in chemical pneumonitis and pulmonary oedema.
2. You will need to upload an image and add it to your page, with the reference and copyright information with the image.
Lipid droplets as ubiquitous fat storage organelles in C. elegans.
Zhang SO, Trimble R, Guo F, Mak HY. BMC Cell Biol. 2010 Dec 8;11:96. 
1. Identify a commercial supplier of an antibody that relates to your group project topic.
Sigma-Aldrich produces 'Monoclonal Anti-Pinin antibody produced in mouse' which is a desmosome associated protein.
2. In mitochondria, where is the gene located that encodes Cytochrome C and what keeps this protein trapped within the mitochondria?
It is encoded by genomic DNA, by CYCS gene.
Cytochrome C is localised within the crista of the mitochondria. This is because it is water-soluble and so cannot pass the lipid membrane.
1. What are the changes in phenotypes that you observe between Group A and Group B?
Group A showed an increase in the percentage of "pronged" and "stringed" phenotype of the B35 neuro-epithelial cells This is opposed to Group B (the control) that showed a much higher percentage of rounder "stumped" lamella, also including "fan" and "broken fan" phenotypes. Group B tended to clump together, altering the morphology of the cells, while - due to the pronged and stringed phenotype - there was still significant cell-cell contact, it only occurred at the tips of the lamella.
There was also moderate colour change observed between the two. In group B, the nucleus was distinctly blue, surrounded by a red cytoskeleton, however in group A, the nucleus was barely discernible as a pink colour while a surrounding pink cytoskeleton. There was also a yellow colour present at the edges of the lamella.
2. How does Tm4 mediate these changes?
Tropomyosin is an integral coiled coil protein that attaches to actin and regulating most, if not all, of its function. There are a number of different isoforms of tropomyosin that are present in different areas of the cell and act on different actin isoforms. They help to confer structure and function to the actin and cytoskeleton. This particular isoform (Tm4) stimulated movement. Tropomyosin inhibits lamellipodium formation and encourages the development of lamellae while enhancing migration. However, the complete mechanism still remains unknown.
1. Identify from one of the cell line repositories: a neural cell line and a muscle cell line.
Neuro-2a (CCL-131) - Neuroblastoma Neuroblastoma
L6 (CRL-1458) - Myoblast Myoblast
2. Identify the species and growth conditions for these cell lines.
- Mus musculus (mouse)
- Base medium: fetal bovine serum to a final concentration of 10%
- Atmosphere: air, 95%; carbon dioxide (CO2), 5%
- Temperature: 37.0°C
- Rattus norvegicus (rat)
- Base medium: fetal bovine serum to a final concentration of 10%
- Atmosphere: air, 95%; carbon dioxide (CO2), 5%
- Temperature: 37.0°C
- Growth Conditions: The myoblastic component of this line will be depleted rapidly if the cells are allowed to become confluent.
- Some gramatical errors under “what is a synaptic junction”
- What happens at each part of the synaptic junctions? Ie what happens at the synaptic cleft?
- Need the basics before getting into different types of junctions ,
- Lots of good information in “types of synaptic junctions” section, but there are many points without much elaboration. For example, if you mentioned two or three important discerning features of electrical synapses, it would be easier to read that 10 different points and minimal explanation
- The chemical synapses section is a lot easier to read, if you follow a similar path for the electrical synapses (how not only what) it’d show your effort a bit better.
- The links for ‘other synapses’ don’t lead to anything
- Good table, it is succinct and information but regulated your use of capital letters
- Need a section to explain function before getting into modulation and regulation, where they’re present etc (everywhere I know, but it would make it clearer to state it)
- In ‘synaptic regulation and modulation’ section, the following paragraph doesn’t make sense – “Graded potentials can vary in size because they depend on the amount of neurotransmitter releasedThis is achieved through the regulation of free calcium inside the cell. Axoaxonic synapses control calcium influx into the presynaptic terminal of . If more neurotransmitters bind to receptors, the amplitude of the depolarization increases. Summation to threshold can occur in two ways, or a combination of these two ways;”
- Need to explain what axoaxonic synapses are
- Neurotransmitter table looks really good
- The abnormalities section looks really good and detailed, lots of information there
- Fantastic pictures that have been drawn, they look really good and concise
- There seem to be lots of spelling errors and gramatical errors throughout, I suggest you go through the whole thing and do a quick edit
- Really good set out, nice and organized, making it easy to read
- The history is really long and detailed. There’s a lot of really good information in it, but it could be a bit better if only the really important bits were outlined. Of course, this isn’t a very big criticism as you can’t really have too much information.
- Good description of the structure. Could you note differences between human gap junctions and their homologues in plants?
- Good incorporation of KO mice in explaining the function of Cx32
- I like how you’ve done the locations of gap junctions, well structured
- It’s a good idea to give a comparison with the other junctions. The table is nice, but since you’re not doing the other junctions do you need that much detail? You could always make links to the other pages or something
- Good variety of abnormalities and nice, brief descriptions
- Nice incorporation of the really recent research, show’s how up to date your information is
- Overall a really good page. Nice work!
- The history looks quite good, nice and concise
- For the structure can we get a bit of a general overview? You seem to have gone straight into the specifics. Or maybe if you refer to the picture or something? There just doesn’t seem to be quite enough information to get my head around the precise structure.
- The ‘molecular components’ section looks really good, well set out and informative, I found it quite readable
- “barrier function” not “barrier funciton”; subheading in “function”
- The “function” section was really good, the pictures there correlated nicely with the content
- Clever integration of tight junction distribution
- In the “classification of epithelia” section, could you break it up a bit? There is a whole lot of information in one go. Maybe put a few subheading? Dot points? Even another picture or so would help.
- I really like how you’ve the table for disease. Really well set out, I like the idea of the links, but what exactly are they leading to? When I click on them I get some random NCBI page. Might want to fix that up a bit. If you could like it back to the page where those structures are discussed I think that’d be pretty useful.
- Some sort of discussion of current research could also be good.
- There isn’t too much to the history, check for some more recent work, ie after 2000.
- You might want to rethink some of the wording in the intro, not a huge problem but it might help with the flow.
- The pictures and info in the “structure” section is really good. I like the addition of the video, it keeps it interesting. Cool video.
- Function is alright, I see you’ve said there isn’t much known about it, but can you maybe elaborate a bit more on the points you have made? Are there examples to show this? Any idea of the mechanism behind embryogenesis? etc
- A couple of grammatical errors in “regulation” section
- In regulation section, “growth factors, the peptide hormones and …etc.”. What exactly do you mean by “and…etc”? Come up with one more example and replace the etc, it would just seem more official.
- Other than that, the information in the regulation section is quite good, I like the set out.
- “Abnormalities in Disease” doesn’t quite make sense. Maybe “Abnormalities and disease”, “Abnormalities causing disease”? Something like that.
- Abnormalities section is quite good, good overview of a few diseases, interesting.
- The addition of the current research is really good
- The table at the end is pretty good, nice overview of other junctions.
- Good history, nicely detailed, but has there been anything since 2000? Surely there has.
- For the mechanism of action, I see what you’ve done with the dot points, but it could be even more effective as a sort of flow chart? That’d be really fantastic.
- A bit further down, I’m getting a bit confused with the format. I know we shouldn’t be commenting on it, but how you’ve structured your information is a bit inconsistent. Ie the dot points. If you could compile it into a succinct paragraph? Or at least elaborate a bit more into the dot points. They are good in a lecture setting (where more information is provided vocally to “fill in the blanks”) but I personally get confused without the complete sentences.
- None-the-less, you’ve got some great information there
- AWESOME table of components. Really good and helpful, especially with the addition of the pictures. I really liked that bit.
- Nice microscopy section, clever addition with some nice pictures.
- Some fantastic information in “skeletal muscle” section, but it’s not entirely applicable to NMJs. Focus more on the NMJ involvement in contraction, as opposed to the details about the structure of actin and myosin etc.
- Interesting stuff about embryology, good work there
- Nice table for the abnormalities, lots of good stuff there
- The research area looks really good, and a clever input of potential future research
- Looks like a pretty good project!
Calcium ion levels are integral in junction assembly. In vitro, extracellular calcium levels have been found to trigger the formation of the junctions.  After cells that have been incubated in low calcium medium, were switched into a medium containing standard calcium concentrations, the formation of desmosomes was seen as soon as 5 minutes.  The deregulation of calcium levels within cells have been associated with junctional defects. Hailey-Hailey disease and Darier's disease are caused by defects in Golgi and ER calcium pumps.  These both lead to a loss of integrity in skin epithelium, due to a lack of cell-cell attachment via desmosomes.  
It has been suggested that regulation of desmosome assembly is closely associated with the assembly of adherens junctions.  Desmoplakin is the only protein, so far identified, that is common to both junctions. In vitro, cells that did not express desmoplakin were unable to localise the proteins specific for the adherens junctions and the desmosomes.  Thus, it has been suggested that it plays a role in segregating the proteins relative to each junction and so affecting assembly.
Phosphorylation has been found to be largely involved in activating and deactivating desmosome assembly. It has been suggested that protein kinase C (PKC) is involved in the regulation of this action.  PKC inhibition is required for desmosome assembly to occur, that is, dephosphorylation encourages formation. Phosphorylation onto serine of desmoplakin by protein kinase C can lead to the disassembly of the cytoskeleton, junctions, and a loss of cell-cell contact. An increase in level of serine phosphorylation has also been linked with an increase in junction solubility of the desmoplakin. This suggests that phosphorylation may play an integral role in the dissociation of the desmosomal plaque from the keratin filaments.  The outcome of plakoglobin (an important desmosomal protein) is also largely dependent on its phosphorylation. 
Images and Videos
[http://www.pnas.org/content/early/2011/03/30/1019469108.full.pdf The three-dimensional molecular structure of the desmosomal plaque]
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- "cell nucleus" Molecular Biology of the Cell
- "nuceolus" Search MBoC Nucleolus
Leena Latonen Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer. Bioessays: 2011, 33(5);386-95 PubMed 21425306
- Constanze C Maresch, Dina C Stute, Marco G Alves, Pedro F Oliveira, David M de Kretser, Thomas Linn Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Hum. Reprod. Update: 2017;1-20 PubMed 29136166 Leslie Citrome Deutetrabenazine for tardive dyskinesia: A systematic review of the efficacy and safety profile for this newly approved novel medication-What is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2017; PubMed 29024264 Valeria Dipasquale, Claudio Romano Vaccination strategies in pediatric inflammatory bowel disease. Vaccine: 2017; PubMed 28967524 Iben W Fischer, Tine M Hansen, Dina Lelic, Anne Brokjaer, Jens Frøkjær, Lona L Christrup, Anne E Olesen Objective methods for the assessment of the spinal and supraspinal effects of opioids. 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Arthritis Rheum.: 2017; PubMed 28465078 Simona Valenti, Romina Gallizzi, Dominique De Vivo, Claudio Romano Intestinal Behçet and Crohn's disease: two sides of the same coin. Pediatr Rheumatol Online J: 2017, 15(1);33 PubMed 28427473 Claudio Romano, Salvatore Oliva, Stefano Martellossi, Erasmo Miele, Serena Arrigo, Maria Giovanna Graziani, Sabrina Cardile, Federica Gaiani, Gian Luigi de'Angelis, Filippo Torroni Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology. World J. Gastroenterol.: 2017, 23(8);1328-1337 PubMed 28293079 Brock E Boehm, John E Cornell, Hanzhang Wang, Neelam Mukherjee, Jacob S Oppenheimer, Robert S Svatek Efficacy of Bacillus Calmette-Guérin Strains for Treatment of Nonmuscle Invasive Bladder Cancer: A Systematic Review and Network Meta-Analysis. J. Urol.: 2017; PubMed 28286068 Miao Wang, Lu Wang, Changfu Liu, Xiangbing Bian, Zhao Dong, Shengyuan Yu Cardiac cephalalgia: one case with cortical hypoperfusion in headaches and literature review. J Headache Pain: 2017, 18(1);24 PubMed 28220375 Martin Vazan, Jens Gempt, Bernhard Meyer, Niels Buchmann, Yu- Mi Ryang Minimally invasive transforaminal lumbar interbody fusion versus open transforaminal lumbar interbody fusion: a technical description and review of the literature. Acta Neurochir (Wien): 2017; PubMed 28160064 Mikael Boesen, Karen Ellegaard, Marius Henriksen, Henrik Gudbergsen, Philip Hansen, Henning Bliddal, Else Marie Bartels, Robert Gabriel Riis Osteoarthritis Year in Review 2016: Imaging. Osteoarthr. Cartil.: 2016; PubMed 27965137 Ana L Neves, Tiago Henriques-Coelho, Adelino Leite-Moreira, José C Areias Cardiac injury biomarkers in paediatric age: Are we there yet? Heart Fail Rev: 2016; PubMed 27255332 Miao Wang, Meichen Zhang, Lei Wu, Zhao Dong, Shengyuan Yu Leukoencephalopathy with cerebral calcification and cysts: Cases report and literature review. J. Neurol. Sci.: 2016, 370;173-179 PubMed 27772754 Ana L Neves, Tiago Henriques-Coelho, Adelino Leite-Moreira, José C Areias The Utility of Brain Natriuretic Peptide in Pediatric Cardiology: A Review. Pediatr Crit Care Med: 2016; PubMed 27749513 Domenico Corica, Claudio Romano Biological Therapy in Pediatric Inflammatory Bowel Disease: A Systematic Review. J. Clin. Gastroenterol.: 2016; PubMed 27636407 Tomokazu Ohishi, Shingo Goto, Pervin Monira, Mamoru Isemura, Yoriyuki Nakamura Anti-inflammatory Action of Green Tea. Antiinflamm Antiallergy Agents Med Chem: 2016, 15(2);74-90 PubMed 27634207 Egemen Küçük, İbrahim Kocayiğit, Candan Günel, Hasan Düzenli Neutrophil-to-lymphocyte ratio in occlusive vascular diseases: the literature review of the past 10 years. World J Emerg Med: 2016, 7(3);165-72 PubMed 27547274 Mehdi Agoumi, Joshua Giambattista, Malcolm M Hayes Practical Considerations in Breast Papillary Lesions: A Review of the Literature. Arch. Pathol. Lab. Med.: 2016, 140(8);770-790 PubMed 27472236 Claudio Romano, Simona Valenti, Sabrina Cardile, Marc A Benninga Functional Dyspepsia: An Enigma in a Conundrum. J. Pediatr. Gastroenterol. Nutr.: 2016; PubMed 27437927 Jing Wang, Lei Zhao, Han Yan, Juanjuan Che, Li Huihui, Wu Jun, Bing Liu, Bangwei Cao A Meta-Analysis and Systematic Review on the Association between Human Papillomavirus (Types 16 and 18) Infection and Esophageal Cancer Worldwide. PLoS ONE: 2016, 11(7);e0159140 PubMed 27409078 A S Lau, G H Adan, M Krishnan, S C Leong What is the publication rate for presentations given at the British Academic Conference in Otolaryngology (BACO)? Clin Otolaryngol: 2016; PubMed 27389579 Javier Vaquero, Francisco Forriol Meniscus tear surgery and meniscus replacement. Muscles Ligaments Tendons J: 2016, 6(1);71-89 PubMed 27331034 Flavio Nigri, Gabriel Neffa Gobbi, Pedro Henrique da Costa Ferreira Pinto, Elington Lannes Simões, Egas Moniz Caparelli-Daquer Hydrocephalus caused by unilateral foramen of Monro obstruction: A review on terminology. Surg Neurol Int: 2016, 7(Suppl 12);S307-13 PubMed 27274402 C F Rocha, R B Vasques, S R Santos, C L A Paiva Mini-Review Monosomy 1p36 syndrome: reviewing the correlation between deletion sizes and phenotypes. Genet. Mol. Res.: 2016, 15(1); PubMed 26910004 K A Jendrissek, T Hotfiel, B Swoboda, S Söder, R Janka [Pigmented villonodular synovitis : A rare differential diagnosis of synovial joint swelling]. [Pigmentierte villonoduläre Synovialitis : Eine seltene Differenzialdiagnose der synovialen Gelenkschwellung.] Z Rheumatol: 2016; PubMed 26768272 L Sharma Osteoarthritis year in review 2015: clinical. Osteoarthr. Cartil.: 2016, 24(1);36-48 PubMed 26707991 Yoshiharu Kawaguchi, Pedro Guarise da Silva, Francine Wurzius Quadros, Luiz Henrique Merlin, Lucas Radaelli, Juan Pablo Guyot, Diego Dozza, Délio Martins, Nicolas Scheverin, Daniel K Riew, Tomoatsu Kimura, Asdrubal Falavigna Analysis of scientific output by spine surgeons from Japan: January 2000 to December 2013. J Orthop Sci: 2015; PubMed 26671572 H Nandeesha, Zachariah Bobby, N Selvaraj, Medha Rajappa Pre-hypertension: Is it an inflammatory state? Clin. Chim. Acta: 2015; PubMed 26525963 Jigar M Dhuvad, Mukesh M Dhuvad, Rajesh A Kshirsagar Have Smartphones Contributed in the Clinical Progress of Oral and Maxillofacial Surgery? J Clin Diagn Res: 2015, 9(9);ZC22-4 PubMed 26501006 C Cavallo, G Faragò, M Broggi, P Ferroli, F Acerbi Developmental venous anomaly as a rare cause of obstructive hydrocephalus: literature review and a case report. J Neurosurg Sci: 2015; PubMed 26439454 Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar PLASMA URIC ACID CONCENTRATIONS ARE REDUCED BY FENOFIBRATE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED PLACEBO-CONTROLLED TRIALS. Pharmacol. Res.: 2015; PubMed 26384444 L Citrome Brexpiprazole for schizophrenia and as adjunct for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antipsychotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2015; PubMed 26250067 Cagri Yuksel, Cuneyt Tegin, Lauren O'Connor, Fei Du, Ezgi Ahat, Bruce M Cohen, Dost Ongur Phosphorus magnetic resonance spectroscopy studies in schizophrenia. J Psychiatr Res: 2015, 68;157-66 PubMed 26228415 Darpan Bhargava, Shaji Thomas, Nupur Chakravorty, Ashutosh Dutt Trigeminocardiac Reflex: A Reappraisal with Relevance to Maxillofacial Surgery. J Maxillofac Oral Surg: 2014, 13(4);373-7 PubMed 26224999 Payam Behzadi, Elham Behzadi, Reza Ranjbar Urinary tract infections and Candida albicans. Cent European J Urol: 2015, 68(1);96-101 PubMed 25914847 Sonja Grunewald, Alexander Jank New systemic agents in dermatology with respect to fertility, pregnancy, and lactation. J Dtsch Dermatol Ges: 2015, 13(4);277-89; quiz 290 PubMed 25819232 L Citrome Lisdexamfetamine for binge eating disorder in adults: a systematic review of the efficacy and safety profile for this newly approved indication - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2015, 69(4);410-21 PubMed 25752762 Francesco Brigo, Stanley C Igwe, Harald Ausserer, Raffaele Nardone, Frediano Tezzon, Luigi Giuseppe Bongiovanni, Michele Tinazzi, Eugen Trinka Terminology of psychogenic nonepileptic seizures. Epilepsia: 2015, 56(3);e21-5 PubMed 25631657 Weisong Liu, Stanley J F Laulederkind, G Thomas Hayman, Shur-Jen Wang, Rajni Nigam, Jennifer R Smith, Jeff De Pons, Melinda R Dwinell, Mary Shimoyama OntoMate: a text-mining tool aiding curation at the Rat Genome Database. Database (Oxford): 2015, 2015; PubMed 25619558 Karsten Gjessing Jensen, Klaus Juul, Anders Fink-Jensen, Christoph U Correll, Anne Katrine Pagsberg Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials. J Am Acad Child Adolesc Psychiatry: 2015, 54(1);25-36 PubMed 25524787 Ammar H Hawasli, Timothy E Hullar, Ian G Dorward Idiopathic scoliosis and the vestibular system. Eur Spine J: 2015, 24(2);227-33 PubMed 25430569 H Laviers, H Zambarakji Enhanced depth imaging-OCT of the choroid: a review of the current literature. Graefes Arch. Clin. Exp. Ophthalmol.: 2014, 252(12);1871-83 PubMed 25363655 Yunhai Zhou, Xiang Zhang, Chen Gu, Jiazeng Xia Influence of diabetes mellitus on mortality in breast cancer patients. ANZ J Surg: 2014; PubMed 25312511 Andrey Bryukhovetskiy, Valeriy Shevchenko, Sergey Kovalev, Vladimir Chekhonin, Vladimir Baklaushev, Igor Bryukhovetskiy, Maria Zhukova To the novel paradigm of proteome-based cell therapy of tumors: through comparative proteome mapping of tumor stem cells and tissue-specific stem cells of humans. Cell Transplant: 2014, 23 Suppl 1;S151-70 PubMed 25303679 L Citrome Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2014, 68(12);1429-41 PubMed 25231363 Wenyan Li, Feng Yang, Yongxian Gui, Junjie Bian DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta-analysis. Oncol Lett: 2014, 8(4);1725-1730 PubMed 25202399 K Nouette-Gaulain, X Capdevila, F Robin, H Beloeil [Intravenous lipid emulsion and local anesthetic-induced systemic toxicity: mechanisms and limits]. [Émulsions lipidiques intraveineuses et toxicité systémique des anesthésiques locaux: mécanismes et limites.] Ann Fr Anesth Reanim: 2014, 33(6);411-7 PubMed 24954124 M Tariq Bhatti, Jonathan J Dutton Thyroid eye disease: therapy in the active phase. J Neuroophthalmol: 2014, 34(2);186-97 PubMed 24821102 Magnus Bruze, An Goossens, Marléne Isaksson Recommendation to increase the test concentration of methylchloroisothiazolinone/methylisothiazolinone in the European baseline patch test series - on behalf of the European Society of Contact Dermatitis and the European Environmental and Contact Dermatitis Research Group. Contact Derm.: 2014, 71(1);35-40 PubMed 24712382 Anatte E Karmon, Eden R Cardozo, Bo R Rueda, Aaron K Styer MicroRNAs in the development and pathobiology of uterine leiomyomata: does evidence support future strategies for clinical intervention? Hum. Reprod. Update: 2014, 20(5);670-87 PubMed 24706045 Massimiliano Cantinotti, Yuk Law, Simona Vittorini, Maura Crocetti, Marotta Marco, Bruno Murzi, Aldo Clerico The potential and limitations of plasma BNP measurement in the diagnosis, prognosis, and management of children with heart failure due to congenital cardiac disease: an update. Heart Fail Rev: 2014, 19(6);727-42 PubMed 24473828 Thomas O Clanton, Lauren M Matheny, Hannah C Jarvis, Anastasia B Jeronimus Return to play in athletes following ankle injuries. Sports Health: 2012, 4(6);471-4 PubMed 24179584 L Citrome Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2014, 68(1);60-82 PubMed 24165478 P Rizzolo, V Silvestri, S Tommasi, R Pinto, K Danza, M Falchetti, M Gulino, P Frati, L Ottini Male breast cancer: genetics, epigenetics, and ethical aspects. Ann. Oncol.: 2013, 24 Suppl 8;viii75-viii82 PubMed 24131976 L Citrome Levomilnacipran for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant--what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2013, 67(11);1089-104 PubMed 24016209 Patrick Francis Chinnery, Gavin Hudson Mitochondrial genetics. Br. Med. Bull.: 2013, 106;135-59 PubMed 23704099 Shoji Yokobori, Zhiqun Zhang, Ahmed Moghieb, Stefania Mondello, Shyam Gajavelli, W Dalton Dietrich, Helen Bramlett, Ronald L Hayes, Michael Wang, Kevin K W Wang, M Ross Bullock Acute diagnostic biomarkers for spinal cord injury: review of the literature and preliminary research report. World Neurosurg: 2015, 83(5);867-78 PubMed 23524031 Steven Hofstetter, Lee Stern, Jacob Willet Key issues in addressing the clinical and humanistic burden of short bowel syndrome in the US. Curr Med Res Opin: 2013, 29(5);495-504 PubMed 23480444 Sobha Sivaprasad, Philip Hykin What is new in the management of wet age-related macular degeneration? Br. Med. Bull.: 2013, 105;201-11 PubMed 23393060 Mohammed Hammoudeh, Abdurhman Alarfaj, Der-Yuan Chen, Hachemi Djoudi, Ehab Youseif, Jian Zhu Safety of tumor necrosis factor inhibitors use for rheumatoid arthritis and ankylosing spondylitis in Africa, the Middle East, and Asia: focus on severe infections and tuberculosis. Clin. Rheumatol.: 2013, 32(3);293-300 PubMed 23242389 B Karahalil, V A Bohr, D M Wilson Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk. Hum Exp Toxicol: 2012, 31(10);981-1005 PubMed 23023028 Fredrik Johansson, Simon Ekman, Erik Blomquist, Roger Henriksson, Stefan Bergström, Michael Bergqvist A review of dose-dense temozolomide alone and in combination with bevacizumab in patients with first relapse of glioblastoma. Anticancer Res.: 2012, 32(9);4001-6 PubMed 22993350 J M Findlay, S Q Ashraf, P Congahan Transversus abdominis plane (TAP) blocks-a review. Surgeon: 2012, 10(6);361-7 PubMed 22975402 Aurélie Névéol, W John Wilbur, Zhiyong Lu Improving links between literature and biological data with text mining: a case study with GEO, PDB and MEDLINE. Database (Oxford): 2012, 2012;bas026 PubMed 22685160 J M Ong, L da Cruz A review and update on the current status of stem cell therapy and the retina. Br. Med. Bull.: 2012, 102;133-46 PubMed 22577179 L Citrome Vilazodone for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? Int. J. Clin. Pract.: 2012, 66(4);356-68 PubMed 22284853 Amnon Peled, Ori Wald, Jan Burger Development of novel CXCR4-based therapeutics. Expert Opin Investig Drugs: 2012, 21(3);341-53 PubMed 22283809 Silvio Altarac, Vedran Cindro, Nikola Radović, Zoran Rajković, Stanko Belina [Feasibility of alpha-blockers in chronic category III prostatitis]. [Uloga alfa-blokatora kod kronicnog prostatitisa tipa III.] Lijec Vjesn: 2011, 133(5-6);177-80 PubMed 21888082 Jasmina Kovacević, Selma Sogorić, Aleksandar Dzakula [Health system research in the Republic of Croatia 1990-2010]. [Istrazivanja zdravstvenog sustava u Republici Hrvatskoj 1990-2010.] Acta Med Croatica: 2010, 64(5);341-8 PubMed 21692257 Maria Aparecida Azevedo Koike Folgueira, Igor Moyses Longo Snitcovsky, Paulo Roberto Del Valle, Maria Lucia Hirata Katayama, Maria Mitzi Brentani, René Aloisio da Costa Vieira Transcriptional profile and response to neoadjuvante chemotherapy in breast cancer. Rev Assoc Med Bras: 2010, 57(3);347-52 PubMed 21691702 D Meininger, M Bück, S Bohlmann, C F Weber, U Strouhal, K Ihlow, K Zacharowski, C Byhahn [Gone with the wind or... Fate of scientific articles presented at large anesthesia congresses--an update]. [Vom Winde verweht oder... "Schicksal" wissenschaftlicher Beiträge auf großen Anästhesiekongressen--ein Update.] Anaesthesist: 2011, 60(2);118-24 PubMed 21060981 Polina Frolov, Jasem Alali, Michael D Klein Clinical risk factors for gastroschisis and omphalocele in humans: a review of the literature. Pediatr. Surg. Int.: 2010, 26(12);1135-48 PubMed 20809116 Daniele Manfredini, Fabio Piccotti, Luca Guarda-Nardini Hyaluronic acid in the treatment of TMJ disorders: a systematic review of the literature. Cranio: 2010, 28(3);166-76 PubMed 20806734 Rezarta Islamaj Dogan, G Craig Murray, Aurélie Névéol, Zhiyong Lu Understanding PubMed user search behavior through log analysis. Database (Oxford): 2009, 2009;bap018 PubMed 20157491 Milind S Tullu, Sunil Karande Leptospirosis in children: a review for family physicians. Indian J Med Sci: 2009, 63(8);368-78 PubMed 19770531 B L Pedersen, N Baekgaard, B Quistorff Muscle mitochondrial function in patients with type 2 diabetes mellitus and peripheral arterial disease: implications in vascular surgery. Eur J Vasc Endovasc Surg: 2009, 38(3);356-64 PubMed 19524462 Ciprian C Secasan Prognostic markers and new, innovative treatments in renal cell carcinoma. Saudi J Kidney Dis Transpl: 2009, 20(3);355-61 PubMed 19414934 Lydia Mary Furman Attention-deficit hyperactivity disorder (ADHD): does new research support old concepts? J. Child Neurol.: 2008, 23(7);775-84 PubMed 18658077 Sotirios Kotsovilis, Ioannis K Karoussis, Ioannis Fourmousis A comprehensive and critical review of dental implant placement in diabetic animals and patients. Clin Oral Implants Res: 2006, 17(5);587-99 PubMed 16958701 Sean A Bydder, David J Joseph, Nigel A Spry Publication rates of abstracts presented at annual scientific meetings: how does the Royal Australian and New Zealand College of Radiologists compare? Australas Radiol: 2004, 48(1);25-8 PubMed 15027917 D W Oliver, I S Whitaker, D P K Chohan Publication rates for abstracts presented at the British Association of Plastic Surgeons meetings: how do we compare with other specialties? Br J Plast Surg: 2003, 56(2);158-60 PubMed 12791363
- F M Watt, D L Mattey, D R Garrod Calcium-induced reorganization of desmosomal components in cultured human keratinocytes. J. Cell Biol.: 1984, 99(6);2211-5 PubMed 6209289
- H Hennings, K A Holbrook Calcium regulation of cell-cell contact and differentiation of epidermal cells in culture. An ultrastructural study. Exp. Cell Res.: 1983, 143(1);127-42 PubMed 6186504
- Taofei Yin, Kathleen J Green Regulation of desmosome assembly and adhesion. Semin. Cell Dev. Biol.: 2004, 15(6);665-77 PubMed 15561586
- R Sudbrak, J Brown, C Dobson-Stone, S Carter, J Ramser, J White, E Healy, M Dissanayake, M Larrègue, M Perrussel, H Lehrach, C S Munro, T Strachan, S Burge, A Hovnanian, A P Monaco Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump. Hum. Mol. Genet.: 2000, 9(7);1131-40 PubMed 10767338
- A Sakuntabhai, S Burge, S Monk, A Hovnanian Spectrum of novel ATP2A2 mutations in patients with Darier's disease. Hum. Mol. Genet.: 1999, 8(9);1611-9 PubMed 10441323
- H Hennings, D Michael, C Cheng, P Steinert, K Holbrook, S H Yuspa Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell: 1980, 19(1);245-54 PubMed 6153576
- E A Bornslaeger, C M Corcoran, T S Stappenbeck, K J Green Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J. Cell Biol.: 1996, 134(4);985-1001 PubMed 8769422
- L S Amar, Shabana al-HM, M Oboeuf, N Martin, N Forest Desmosomes are regulated by protein kinase C in primary rat epithelial cells. Cell Adhes. Commun.: 1998, 5(1);1-12 PubMed 9638337
- L S Amar, A H Shabana, M Oboeuf, N Martin, N Forest Involvement of desmoplakin phosphorylation in the regulation of desmosomes by protein kinase C, in HeLa cells. Cell Adhes. Commun.: 1999, 7(2);125-38 PubMed 10427965
- M Pasdar, Z Li, H Chan Desmosome assembly and disassembly are regulated by reversible protein phosphorylation in cultured epithelial cells. Cell Motil. Cytoskeleton: 1995, 30(2);108-21 PubMed 7606804
- Leena Latonen Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress. Proteasome inhibitors induce nuclear ribonucleoprotein inclusions that accumulate several key factors of neurodegenerative diseases and cancer. Bioessays: 2011, 33(5);386-95 PubMed 21425306
- Jorge Múnera, Grace Ceceña, Paul Jedlicka, Miriam Wankell, Robert G Oshima Ets2 regulates colonic stem cells and sensitivity to tumorigenesis. Stem Cells: 2011, 29(3);430-9 PubMed 21425406