Talk:2015 Group 3 Project

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2015 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

--Mark Hill (talk) 08:42, 21 May 2015 (EST) Your Group Project will now have peer feedback from the class, use this feedback to improve your project before submission.


Group Assessment Criteria

  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of cell biology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.

Group 3: Z3463637 | Z3374116 | Z3332339 | Z5050826


Assessment

  • This reference (Biochemistry of tropoelastin. Vrhovski B, Weiss AS. Eur J Biochem. 1998 Nov 15;258(1):1-18. Review. No abstract available. PMID 9851686 ) is a good review article to introduce your topic. One key point is that it is a "review" not original research and should have been cited as such. For example "as reviewed in" or "see review". It is important to discriminate between original research articles and reviews in your writing.
  • I liked the inclusion of "Additional Information" collapsible boxes. Allows more information to be available without breaking the project flow.
  • History - some good historic information included in this section.
  • Structure and Components - "made significantly of only four hydrophobic amino acids: glycine, alanine, valine and proline. " should have indicated how this aa components contributes to the elastic fibre structure.
  • Microfibrillar Associated Proteins - good, where are some images of these molecules?
  • Assembly of Elastic Fibre - I liked this section introduction of molecular concepts.
  • Step by Step Procedure of Elastic Fibre Formation - this was a good table summary of the sequence of events. No indication of the data source used in preparation of this table?
  • Function - comprehensive histological coverage. Would have liked some more information on elastic fibres physical properties.
  • For more Information on the function of Tropoelastin - should this box not have been in the structure section?
  • Clinical Significance - several good examples cited here.
  • Vitamin A deficiency and alterations in the extracellular matrix - you did not explain how this affected elastic fibres.
  • Future Directions - was a good close, but I would have liked more examples given here.

Edits

Student - (All, May)

  • Z3463637 - 185, 142
  • Z3332339 - 120, 57 Majority of edits in last week of project.
  • Z3374116 - 50, 38
  • Z5050826 - 41, 41 No edits at end of project.

Images

  • Z3332339 - 6 images
  • Z3463637 - 4 images
  • Z3374116 - 2 images





Hey there guys, there are some interesting subtopics that we can discuss under the topic 'Extracellular Matrix'. Theres quite a bit of information on the different fibre types in the ECM as well as the mechanical properties of ECM. I think we should do a bit of simple research first and find which one we can find the most easily accessible information as well as which one seems more interesting to you guys. --Z3374116 (talk) 23:03, 22 March 2015 (EST)

--Z3463637 (talk) 11:21, 23 March 2015 (EST) Collagen would be a pretty easy topic to do! Theres quite a bit of information about this. I can see another group after this as well though... we should decide soon.

--Z3463637 (talk) 21:45, 23 March 2015 (EST)-- Well, collagen has been taken now so... Elastin? Seems like the next best option. We need to decide asap before all the good ones get taken. Please reply!!!!!

--Z3374116 (talk) 01:03, 24 March 2015 (EST) Elastin seems nice and simple!!

--Z3463637 (talk) 08:48, 24 March 2015 (EST) Elastin it is! I changed the heading for our page, before another group takes it. We can always change it if the other 2 members disagree.

--Z3332339 (talk) 09:18, 25 March 2015 (EST) Hey guys I think Elastin is a great topic to do! I think there is lots of info on it as well

--Z3463637 (talk) 18:01, 26 March 2015 (EST) IDEAS FOR SUBHEADINGS:

- Introduction

- History

- Structure - z3463637

- Function - z3332339

- Assembly -z3374116

- Clinical Significance [Does this cover the mutations?] - z5050826


Here are the subheadings we have so far, feel free to add more to this list and pick one to research.

--Z3463637 (talk) 21:00, 27 March 2015 (EST) Yes, clinical significance will include abnormalities/diseases associated with elastin.

Lab 3

In silico analysis suggests interaction between Ebola virus and the extracellular matrix. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333865/ <pubmed>PMC4333865</pubmed>

Matrix metalloproteinases in destructive lung disease. http://www.sciencedirect.com/science/article/pii/S0945053X15000396

Thrombosis, like other cardiovascular diseases, has a strong genetic component, with largely unknown determinants. EMILIN2, Elastin Microfibril Interface Located Protein2, was identified as a candidate gene for thrombosis in mouse and human quantitative trait loci studies. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319747/ <pubmed>PMC4319747</pubmed>

Vitamin a deficiency and alterations in the extracellular matrix. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245576/ <pubmed>PMC4245576</pubmed>

--z3374116 (talk) 15:28, 20 April 2015 (EST)

ASSEMBLY OF ELASTIN FIBRES

Article 1

Research article breaks down the main components of Elastin describing its characteristics. Observations on the alternating hydrophobic and cross-linking characteristics within Elastin are described. Focuses on explaining in depth the basis of self-organizational ability of elastin-based polypeptides and how the information from them can possibly assist in developing self-assembling biomaterials.

<pubmed>11911775</pubmed>

Article 2


<pubmed>25811498</pubmed>

Article 3

This article focuses on investigating the mechanisms behind the elastic fiber assembly via observing the molecular interactions between 'elastin' and 'microfibrillar' components using solid-phase binding assays. Observations found that the major cross-linking region in elastin is formed by association of domains encoded by exons 10.19 and 25 of tropoelastin.

<pubmed>8575256</pubmed>

Article 4

<pubmed>1648323</pubmed>

Article 5

<pubmed>18228265</pubmed>

--Z3463637 (talk) 11:18, 2 April 2015 (EST)

Article 1

The study highlights the role of recently identified glycoproteins on or surrounding elastic fibers of tissues and organs. Short fibulins, particularly -3, -4 and -5 have very potent elastogenic activities. The activities of these short fibulins were observed in knockout mice and it was found that they play an integral role in the formation of elastic fibers. This review article is relevant to the formation and structure of elastin.

<pubmed>PMC2880191</pubmed>

Article 2

Before manufacturing biomaterials, the biopolymer materials must be assessed based on their functionality and design parameters. The review article discusses the different biopolymer materials, including elastin, highlighting its structure and functional properties. It is found that a integrated design approach using experimental and computational modeling procedures are required to study these materials.

<pubmed>22938765</pubmed>

Article 3

Elastin is necessary for the elasticity and recoiling properties that are evident in blood vessels. In a study of elastin knockout mice, it was revealed that elastin also plays a role in arterial morphogenesis. This review article is relevant to the sub-topic as it highlights the functions and structure of elastin.

<pubmed>24679588</pubmed>

Article 4

Previous studies have shown that developing arteries and neural crest EGF-like (DANCE) proteins are essential for the formation of elastin. The identification of latent transforming growth factor-β-binding protein 2 (LTBP-2), was found to promote the deposition of DANCE proteins onto fibrillin-1 microfibrils. This ultimately induces the formation of elastin.

<pubmed>17581631</pubmed>

--Z3332339 (talk) 22:49, 26 April 2015 (EST)

Lab 3 Assessment


Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves [1]

Elastin is commonly found in the arteries due to the high pressure of blood coming from the heart, and its function to supply oxygenated blood to all organs, its elasticity is important due to enormous pressure it needs to withstand. Pulmonary arterial hypertension (PAH) causes stiffness in these arteries affecting the ability for these arteries to stretch and maintain a relatively constant pressure with high blood flow. This article looks at the structure and function of this relationship in PAH and the mechanobiological adaptations that are undergone by elastic arteries in response to PAH.


Comparison between human fetal and adult skin [2]

Elastin is important in adults for restoring backing the normal tissue architecture example pinching of skin. According to this research, extracellular components such as elastin are important in the scarless healing process that takes places in on early fetal gestation. The role that elastin or another name, tropoelastin is investigated. Elastin is not found in fetal skin up till week 22. Although it is not a primary extracellular component for scarless healing in fetal wounds, it is still plays a role in skin regeneration. A comparison between fetal skin and adult skin is looked at.


Spatial Distribution and Mechanical Function of Elastin in Resistance Arteries A Role in Bearing Longitudinal Stress [3]

Arteries within the human consists of three layers and are most evident closest to the heart due to the properties that make them withhold the enormous pressure the heart pumps. The walls of the arteries exist in three layers where the outermost layer, called the tunica adventitia providing tensile strength, the hypothesis this research grouped investigated was whether the elastin fibres are subject to longitudinal stretch.


Tropoelastin - a versatile, bioactive assembly module [4]

The monomer for elastin is tropoelastin. Thus when many Tropoelastin molecules are bonded together (covalent bonds )with cross links such as lysal oxidase [5] they bind together to form the protein elastin. There is only one gene for that codes for tropoelastin and thus only one protein. The research stems on the facts that tropoelastin is compatible with synthetic and natural co-polymers. As a result of this, it enables these researches to expand upon the applications of its potential use in next-generation tailored bioactive materials such as when responding to injury. this is because large quantities of the monomer have only become accessible recently. Isolation of tropoelastin was previously intricate and inefficient due to its rate of cross linking incorporated into growing the elastic fiber in the living. However by synthesizing the elastin gene, this has allowed for a recombinant tropoelastin that is identical to the naturally secreted human form giving that compatibility that allows scientist and research to work with in a versatile way.


Insights into the role of elastin in vocal fold health and disease [6]

Elastin can be defined as a an extracellular matrix protein that is responsible for tissue elastic recoil. Therefore, because of its function it can then be assumed that it is found in different parts of the human body that require tissue recoiling. For example, lungs(30%)- expansion when inhaling and exhaling air, large arteries (70%)-to be able to recoil back to their shape consistently as blood is bumped through them, skin (2-4%)- to be able to withstand stretches and sustain its original shape. Elastin can also be found in the vocal fold of the lamina propria, making up 9% of the total protein. Thus, the lamina propria experiences greater amounts of mechanical strain relative to skin but less when compared to lungs and arteries.


--Z3463637 (talk) 20:35, 11 April 2015 (EST) I will also be talking about distribution in the "structure" subheading.

--Z3463637 (talk) 00:26, 23 April 2015 (EST) I've started working on the introduction, and i'll include the distribution here instead. Feel free to change or add anything to the introduction! How is everyone going with their sections? Also, I haven't found much about the history of elastin in my research - maybe we can exclude or replace this heading if we can't find much information.

--Z3374116 (talk) 15:46, 23 April 2015 (EST) Ill try help search for historical info as well (I think it might be good to even have a little bit of historical information). We could add more subheadings as seem fit provided we can finish our sections :p. Been searching for my part finding some good stuff, just need to slowly paste stuff into our wikipage. The weather and blackouts havent helped much. Lets slowly get things rolling.

Thanks for adding the intro

--Z3374116 (talk) 18:07, 23 April 2015 (EST) Mark said that because we have such a specialized structure, we need to know everything about all things related.Interactions, genome etc.

Pubmed Protein Database / Pubmed Genome Database


--Z3332339 (talk) 22:55, 26 April 2015 (EST) Ok i had my section on just the wiki page but not here on discussion but i just pasted it here as well just in case because i reread the assessment item and it said discussion page. Thanks for adding the intro :) I remember him saying those things too and i remember him saying include any isoforms of it, I also remember him mentioning the word Mendelian ..but im not sure what he means by this.. do you guys recall?


--Z3332339 (talk) 17:54, 30 April 2015 (EST) Hey guys so from todays feedback from Mark we need to look at

-expression

-how its made

-gene that codes for it

-knock out mouse database

-fibre (aus one)/fiber- and write this in intro

-degradation

-turn over of elastin--arteries, get stiff

-distribution-tunica intima and tunica externa

-components of elastic fiber

-interaction

-organs

-histological images


--Z3463637 (talk) 13:04, 3 May 2015 (EST) I moved the component's subheadings under structure.

Heres the intro you wrote under components z3374116 - I think it should go under the "Assembly" heading. I understand how closely related these two sections are, but i will try to talk about the interactions of the componenets only very briefly, without talking about assembly too much.

The formation of Elastic fibers is a complex process which is comprised of multiple interactions between different proteins, enyzmes and binding sites. Elastic fibers are mostly comprised of Elastin and Micro-fibrils which consist make up most of the structure, the processes of formation are closely regulated and carried out by the smaller protein components; Tropoelastin, Lysyl Oxidases (LOX), Fibrilin-4 / Fibrilin-5 and Integrins


--Z3332339 (talk) 09:39, 4 May 2015 (EST)

He also said Histological diagrams, so i added it to the list :)... he also said he could give us some too :P

--Z3374116 (talk) 16:11, 4 May 2015 (EST) Mark also told us to include hand drawn diagrams it to our project, Im currently drawing mine out (assembly steps). Lets try sort all this out by this week Thursday because peer assesments are coming up!

--Z3463637 (talk) 22:23, 4 May 2015 (EST) I will most likely be drawing a picture of elastic fibre - there aren't many decent pictures out there. I deleted the "history" heading, because of the upcoming peer assessment. We can put it back up if we find information on it, but if not we won't have a "history" subheading.

The page doesn't have to be completely done for peer review right....?

--Z3374116 (talk) 00:01, 7 May 2015 (EST) The page doesnt have to be complete for peer assessment, but having it done would be best i guess haha. Making my assembly part more formal and informational

--Z3374116 (talk) 17:57, 7 May 2015 (EST) http://cdn.intechopen.com/pdfs-wm/19028.pdf [Elastin Based Constructs]

  1. <pubmed>PMC2593497</pubmed>
  2. <pubmed>PMC2799629</pubmed>
  3. <pubmed>PMC3380608</pubmed>
  4. <pubmed>PMC3879170</pubmed>
  5. <pubmed>PMC3190022</pubmed>
  6. <pubmed>PMC3190022</pubmed>

Group 3 peer review

Good, short and concise introduction to the topic. You briefly touch on a bit of the history of elastin in the tropoelastin and elastin section (about the study of it being hindered), potentially this could be moved so its after the intro section, with a bit more detail on the history of it? Alongside the text describing the structure it may be useful to have some diagrams of it so people can visualise it next to the description. Really like the way you’ve put the key words in bold, really makes them stand out! The section about the assembly of elastic fibre is really good, really good hand drawn image and other diagram obtained is clear and informative. Good use of number bullet points to split up the text and explain the process. I don’t think much would need changing in this section, except some of the words i.e. Lysyl Oxidases have already been abbreviated (LOX) in the previous section, so don’t think it’s necessary to do it again. The function section seems a bit disorganised because a brief intro to the function is given which refers to a diagram further down the page and then following this is a random bit on tropoelastin, so I think this section should be moved to somewhere more appropriate or use a different heading. Also, instead of using the paper titles as the subheadings I think these should be summarised into a shorter title. Good use of diagrams in this section, maybe if they were made square to the text it’d look a bit neater. The clinical significance section is very informative, lots of information which is good and I like that a range of conditions have been used – nice and topical using ebola virus. The only thing for this section to improve on would be the addition of videos/images to split up the text.


Group 3 peer review

The page is looking good. The introduction is very well written and appropriately summarizes the whole page. However, I noticed that you don’t have a history/timeline/current/future research section. It might be good to include those sections briefly at the beginning as it would make the page more interesting and provide context for your reader.

In the structure and components section, it might be beneficial to include a diagram of the molecular structure of elastic fibers or possibly draw something so the reader can relate what you’re describing in the text to a visual diagram. I thought the diagrams you used in displaying elastic fiber assembly were very effective but that section might be better if the process was more simplified in text form as well.

It would be great to have visual representations of the diseases such as Ebola in the clinical significance section as it would make it more interesting. It might also be better to simplify some of that information as there seems to be a lot of text. The functions section is good but it might be more effective if you added a subtopics into that section dividing it into different parts e.g. heart, skin.

Overall, I think the page is coming together well.

Group 3 peer review

Your webpage has many positive aspects to it. I thought the organization of the material on the page was great. You also made the material easily understood for readers without prior knowledge of the subject. I thought the rubber band analogy was a good idea to include in your webpage as it gave a good mental picture for the reader, making the subject relatable. It was evident that thorough research of the subject matter was conducted.

To make your webpage better, I would suggest going through and re-reading for grammatical errors as there were some run-on sentences as well as issues with sentence structure. There were some points where phrases were re-used multiple times within a few sentences. For example, 'of elastin' became repetitive within the Tropomyosin and Elastin section.

I appreciated the hand drawn image you created. It seemed very informative. However, the words in the key along with the labels were not legible. With correction of this issue, the image would be fantastic to incorporate. I thought you included a good ratio of photos to text within your webpage. There were photos in the Heart and Lungs sections that needed legends. Otherwise, I thought your project was well-written and consistent in information depth throughout.


Group 3 Project Review In terms of content, I’m very pleased with the page. It’s not overly long (but could do with some trimming down), but all the relevant and expected information is present. There’s a little too much text, so I’d recommend replacing some of your larger concepts with a picture equivalent. For example, much of the discussion on microfibrils could be discussed with a diagram. The Clinical Significance subheading also desperately needs a picture or two. I understand that it’s probably difficult to track down a picture on the role of elastic fibres in Ebola or thrombosis, so you may have to draw it.

The biggest problem here is with readability. I really had to force myself through this because, while it was interesting, it was fairly difficult to interpret. There are widespread grammatical abnormalities that need to be addressed. These are especially prevalent in the Introduction and Structure and Components sections, but do infiltrate other sections as well. I strongly recommend you go over each other’s sections with a fine-toothed comb to try and get all the grammatical errors out, because it really affects the readability of your page.

Also, small thing: get rid of Dr Hill’s “please have something ready for the next lab” notice. You also have some empty references (23-25) – that’s probably due to an easily fixed bug in your code.

Overall, I think the wiki page is very good in terms of content, but needs some work as far as presentation goes. The only real changes that need to be made to the content is addition of more pictures and the corresponding excision of unnecessary details. Most of your focus now, however, should go into making your page as easy-to-read as possible.

Group 3

Group 2 is doing their project page on Elastic Fibres. The first thing that needs to be developed is the introduction, but it is understandable that you need the rest of the information to be finished before you can summarise it simply in the introduction. There is good use of illustrations and pictures to summarise the information accompanying it, but as I scrolled down I got confused when the information transitioned suddenly to examples in the heart, lung and skin. It would be good if there is a separate heading to clearly mark out the examples regarding how elastic fibres function in common tissues where they exist. The images in that section also need to be referenced, may have to ask Mark how to do it if you got it from virtual slides (it looks like those images). There are some uncompleted parts here but thats fine as well, as long as they are finished soon. In the diseases section, are there any pathways related in the diseases that involve other molecules that interact with the elastin? Do these diseases illustrate the role of these elastin fibres in the extracellular matrix? You may want to make sure that references section is actually a new section, I have a feeling that the coding is wrong. Overall I think this is a project in development, but the elements are all there, just need to be developed a little :D good job!

Group 3 Peer Review

Overall, I think your page is coming together really well and on the border of completion!

Key points clearly described: I felt that the key points were clearly described, and didn’t feel that I had any difficulty in understanding any of the components. However, I think your page does need a bit more information. For example, under ‘Skin’, when you mention that the skin is composed of five layers, I think you should address/ list these five layers (however I do see an article there, so I’m assuming this is a work in progress). The same goes for ‘Spatial Distribution and Mechanical Function of Elastin in Resistance Arteries’, where you mention ‘three layers’. They are labelled in the image, but I think you should address them in the text as well. Just a note, I really liked your analogy to the rubber band! I thought it worked well!

Understanding? Content, headings, sub – headings, diagrams, tables, graphs? Teaching at peer level? Own innovative diagrams, tables or figures, Interesting examples or explanations?: The images used were good and relevant to what was being described. I do think that you need to include a lot more images though, particularly in the function and clinical significance section to break up the text. I really liked the ‘Process of Elastic Fibre Assembly’ image that you created. It’s really well done! However, I noticed in the text that you describe the steps in the image from 1 -5. This is not obvious or very clear. Maybe you should either centre the image and have the steps following or include the steps in the image description. Also, under the ‘Spatial Distribution…’ heading, the images you have are really good, but the one on the right I feel needs to either be referred to in the text or described in a text box, because it is not clear what the image is showing. Overall, in terms of images, spread them out so they are not clumped together, or even on the same side of the page consistently.

Content correctly cited and referenced: Everything appears to be referenced well. Don’t forget to remove the reference link under Skin!

Evidence of significant research / Adequate research: It appears you have done a great deal of research, and your concepts are clearly well – covered. Just fill in the little gaps I mentioned (layers of skin and three layers), and find supporting articles for areas where only minimal references have been made. The more articles you look at and derive information from, the better and more credible your page will sound.

Other: There is quite a few grammatical errors. Just fix that up. And on another note, under the ‘Tropoelastin and Elastin’ title, if you talk about elastin first, I think it is more logical that the heading has elastin first.


Group 3 Peer Review

The project is amazing, guys, really!! The content is very rich, the text is clear. The images shown are good and helps a lot in the understanding of the content.

I cannot say that I found problems in what you guys have written… The only I can say is that a section with history would be an interest thing to add on the page. Furthermore, the section about clinical diseases could have more images, because the great amount of text makes the reading tiring. However, if the reader finds enough energy to go through this section, he or she will have plenty of information about the diseases involved with the elastic fibres. A section about current and future researches would also be great. Despite these little problems, the page is very good, I would give you high marks if I could! Congratulations, keep on!


group 3 peer review

Group 3, overall you guys have made a pretty good and solid work. The structure, headings and subheadings are well explained, I just think there could be somethings about the history of some of the elastic fibres, as well as current research and treatment can be contemplated. The drawing was so far the best I have seen among the groups and the other images are very elucidative, I just think you could add something extra to the clinical significance to give a break on the reading as there is a lot of information. Furthermore, I think you could have some more extra references; that would enrich your work even more. Apart from that the rest is looking really good. Nice job!


Group 3: Pros: It is evident you guys have done a lot of research for your topic and the pictures helpful in understanding the topic you guys are exploring. You have utilised your own innovative diagrams.There is an adequate amount of information in each section. The content is referenced Cons/improvements: You guys could improve by using more subheadings. There is no history/current research section. The histology pictures could be better positioned to maintain a flow in the page


Group 3 Peer Review

The page is very good. The introduction is clearly and briefly and it gives a good idea about Elastic Fibres. The structure and components section is clearly, but I think a image would help to understand. Finally, I noticed that you did not put something about history and future researches that would be good in the beginning of the page.

The “Assembly of Elastic fibre” is good too, and I really like the draw about the process of elastic fibre assembly. The other image (Role of MFAP-4 in Elastic fiber assembly) was well-chosen too. Finally, I like the step-by-step that you made in the final of section, because it summarizes the process being very informative and the reader can see the images at the same time. However, the images should be referenced correctly.

The functions related with organs, like heart, lungs and skin was a great idea. Also, the clinical significance you chose relevant diseases to relate but I think you could explain more deeply how the elastic fibres are related with this diseases. Also, I think some images in this section would be good to break up the text and the reader would feel stimulated to read at all.

Overall, the page is very clearly and informative so far. I think there are few little problems such as images referencing but I am sure that the page is still in progress and you will fix it. Also, it would be more informative if you include more images.

Peer review

The introduction is well written as it is accurate and concise. You have briefly mentioned the discovery/history of elastin in the structure and components subheading. You may want to create a section devoted to history as it is always nice to know how we know the things we do today. Mark also seems to love history :).

The structure section is well done, I especially like how you talked about the synthesis of an elastic fibre. The hand drawn diagram is also very good as it is colourful which captures the viewers eye but is also very informative (it makes my drawing look bad)

The function section has been done really well, providing the reader with easy to understand information. However the two images in this section have no caption. How is the viewer suppose to draw information from this if they don’t know what it is? On a whole, I think the page needs more visual material such as pictures or videos such as something to support the rubber band analogy. Have a video showing an elastic band stretching and returning to its original size? That’s just a suggestion it is already pretty well explained.

From the looks of things the referencing has been done correctly, there are no duplicates in the reference list from what I can see. However, there are a few empty slots which Im guessing they are not pubmed articles. You need to manually put them in which is a pain but easily fixed :). The images look correctly referenced from what I can tell, containing the appropriate copyright information.

Overall, I think this page is coming together really well. There is still more research that needs to be done and you need to make sure you try keep a balance of visual and written media to keep the viewer engaged.

Group 3 Peer Review This page is super easy to read. I love the clear use of sub-headings, which really make the different sections easy to read. Especially for the clinical significance section, it's easy to look at the different ways molecular defects can correlate to medical conditions. Perhaps more detail on how elastin brings about the clincal problems of the disease is needed. The diagrams are simple and well used, and don't require too much deciphering - often times, diagrams for these sorts of complex molecular processes are super complicated and require a significant level of pre-requisite knowledge to interpret (e.g. knowledge of certain mediators, enzymes etc.). There is a fine balance between not being too simplistic and not being over complicated with regards to the diagrams.

Group Review 3

This page is close to finished with all of heading filled out with decent amounts of content. The introduction doesn't properly represent the rest of the article, redoing it would be preferable. All sections have enough content to grasp the concepts being presented. The main thing I would like to see subheadings on brief overview on historical research on elastic fibres and some moderately in-depth examples of recent research.

Structure and components is well organised addressing structural aspects and some relations to process of discovery. This section displays bolding of key molecule/structures/substances which obviously highlights their importance at the sacrifice of the paragraphs attractiveness and creates some confusion. Elimination of bolded text and would be recommended. Assembly content is strong with good referencing at the start which lacks in the later paragraph and the Assembly list. The assembly list should be more distinguished from the paragraph above it a table with alternating colours would make a visually appealing presentation. Structure serves as function section had a lot of words without any reference; even though the content is general the lack of referencing is unappealing. Function section is structured as if it is reviewing individual articles instead of taking information from multiple sources of information to create an overview on a specific field. This results in the this section to have an unnatural flow from overly specific topic to overly specific topic. The key thing I would change here is the long subheadings and first sentences. A nice variety of clinically related conditions are presented with nice amount of content though it seems information was sourced from.

The referencing for the majority page was good except for clinical section in which each condition only had a single reference more references are required to increase credibility. The image used is placed near relevant content though those in the functions section are not formatted properly/referenced. An addition of two images to the structure section and one for each of the clinical conditions would break up the boring walls of text.

Group 3 Peer Review

Hello group, I really enjoyed reading your page. The structure and overall order of your information is the best in my opinion of all the projects. You've been very intelligent in your layout. Some points of potential improvement for me include revising your introduction section. I'm not a fan of your image there, its boring and not very informative. Something more eye-catching or colourful would be a better choice. Also you seem to just jump straight into your topic, its really helpful to put your topic in context first, just so the reader can orientate themselves. A history section would really help you out with that.

In the middle sections of your page, there are big chunks of text that are really bland. Including more images would help break this up and might even allow you to transfer or cut some of the text and instead have visuals to help explain. One section i was really impressed with was the assembly one, even though there is a block of text, i felt the images were chosen well and really complemented what was written. The histological images are towards the end of the page are also good, they're interesting to look at and well formatted to fit on the page in an non-obstructive way.

As a group, you are almost done with your page. Keep going with the great work and good luck


Good start with introduction. Just don’t forget to mention everything that is included in your page when doing the final touches. It is obvious that “Structure and Components” section is very well-researched. I see overlaps in references, which is an indication that whoever wrote this section used other papers to confirm that the information they wrote is consistent with others. If you could, include a photo of each structure, that would really help with visualising and understanding the information written. The “Assembly of Elastic fibre” is very good! I like the student-drawn image and how the steps are included within the text. Don’t forget to include something like “refer to image a” before listing the steps and also add “Steps in elastic fibre assembly” in bold to make the steps stand out. One issue I have is the Role of MFAP-4 image. I don’t see how that relates with the information you included.

With function, I like how you discussed the function of elastic fibres in different organs of the body. This is consistent with what you mention for introduction and structure. There is a good amount of references however, they’re not intertwined with the other references used. Try to merge your information together rather than have them in separates chunks. There are a few images but don’t forget to mention them in your text to justify how your photos relate to your information. Also, add descriptions under your photos. With your abnormalities section, well-written and easy to understand. You included a good description of each disease and their effects to the body. You have mentioned that elastic fibres plays a role in some of the diseases however, I find that you didn’t really explain how they cause or add to the effect of the disease. Just try to work on this. I find that using 3-4 papers for each disease is enough to get a good amount of information. If possible, add treatment.


Group 3:

As a whole, this page is very informative and contains great images and an illustration. However, I think it may be a good idea to make some changes to the layout of the page, such as the positioning of images, so as to make the page more aesthetically pleasing. While the introduction is brief, it gives the reader a good understanding of what the page is about. However, note that there are minor grammatical mistakes present in this section, as well as others, which need to be addressed. In particular, there are different spellings of fibre utilised throughout the project.

Furthermore, more images can be implemented to accompany the text. Specifically in the case of clinical manifestations, it would be good for the reader to have a visual representation of what these abnormalities are. Also, I think it would be a good idea to add a history section as it provides the reader with the background context of elastic fibres, and a glossary to clarify terms for the reader. Lastly, make sure that you guys proof-read through the reference list as there are some that are blank.

Group 3

Very nice job! Your page is clear, concise, organized and well formatted. Your own image is outstanding, very nice draw and paint. Maybe would be a good idea to add some pictures to the "Clinical Significance" section, is nice when we have something to illustrate the problem. I also noticed that some references are missing, make sure you will fix this before the submission. Congratulations!

Group 3 Peer Review

Wow, your page is really well developed. The introduction is clear and I feel as though the key points that are addressed in the remainder of the wiki are briefly mentioned here. A good start.

Headings are good and I think the ‘Assembly of Elastic Fibre’ heading/paragraph, is a great addition between the ‘Structure’ and ‘Function’ headings and to your wiki page in general. I’m being picky, but your heading ‘Tropoelastin and Elastin’ should read ‘Elastin and Tropoelastin’ because your information below begins with information on Elastin first.

The images are all placed in appropriate spots and the information that refers to them is very well done. The hand drawn image, ‘Process of Elastic Fibre Assembly’ is superb and aids in my comprehension and understanding of the concept your were trying to explain.

I think your wiki could include some information on the developmental stages of elastic fibres (from the embryo and compare it to the final stage of the fibre in an adult?)

The comparison of elastin fibres to a rubber band was genius, and allowed me to further understand and get an idea of just how essential elastin fibres are! This was a good way of showing that you can teach at a peer level. I like how you related the function of elastin with heart, lungs and the skin – a great idea.

More information and research needs to be added under the ‘Skin’ heading. I think you are going to do this anyway, but add some information on the five layers of skin and maybe include an image (it would be useful and also because ‘Heart’ and ‘Lung’ also has one!)

Images and/or a table could be used in the disease section. There’s a lot of information to get through and this may be useful.

Fix up the spelling mistakes before submission and also be consistent with your spelling – fibres vs fibers.

Group 3 Peer Review

I think this one of the the better pages that I've seen so far from all the others. The structure is laid out really well and the content is clear, informative and easy to understand. I think the amount of content is consistent and balanced for each sub topic. This is great because it's not too overwhelming to read and it's also interesting. Your referring is also done really well. I did notice some in text citations weren't in the correct form, I'd suggest changing them. Your images are really great, maybe try to add some more throughout the page especially in the clinical significance sub topic, to make it a bit more vibrant. Great work in having that drawing under the assembly of elastic fibers, looks good. Another suggestion is to maybe have a bit more info in the introduction as it seems a little small, but it's understandable that you haven't filled it out completely as its the part that you do at the very end. So once you've finished everything else maybe just add another paragraph to it to highlight what the page will cover and a general overview of the topic and your page. Overall the page has been set out really well there's nothing that really needs changing, so I don't have many suggestions to make. I think you should just add a few more image, drawings or tables here and your good to go.

Really great effort everyone ! :)


Group 3 Peer review The amount of information on this page is excellent, although it looks like it may be missing some citations in areas. With this great amount of text, some more formatting with more pictures added would go a long way. The student drawing looks amazing, whoever made it should do a banner at the top of the page as well! The pictures that are included should have some work done in their formatting to have them more central with the text as currently they are serving to pull attention away from the information present in the text. Missing a history and current/future research section. Not sure if that's intentional, but they both can serve and a good way of orientating the reader into the information and then lead them off to further reading if they are interested in the topic. It's a very good project, but i can't stress enough. Formatting and pictures!

Project 3 Critique: I really liked that you began your project with a general overview of your topic that was not too complicated or too detailed, it allows the reader to understand what your topic is. However, you may want to also include what aspects of elastic fibres you will be discussing and what you won’t. The way you organized your structure section was really great, but I think an image of a general elastic fibres with the labeled components would be really helpful in understanding how the components fit together. As far as your assembly section goes, the diagrams that you have a re really great, especially the hand drawn diagram, it is eye catching and engaging, well done. I also enjoyed the organization of your function section, how you discussed function in the scope of specific tissues, but I think the images in this section may be just a bit too large, as they result in a very large white space to the right of the images, perhaps just something to consider. I also found your clinical examples and organization of that section to be very good, I enjoyed that you have very distinct examples of clinical implications.

Group 3: Elastic fibres

Good work with your introduction. The structure and components section could would benefit with the inclusion of images to help the audience understand the concepts. Apart from this minor issue it is clear that the people behind his section have put a lot of effort into presenting a well written and extensively sourced section. The student drawn image is great and is well described.

The function section follows the organisation of the page in describing the roles of elastin with regards to different organs in the body - this is a great way of presenting your information as it makes it easier to understand. You have used images which is good but there needs to be some sort of reference to them in your text to help tie them into the section otherwise they just seem to be placed there for the sake of it. You could do this by adding captions under the images and then giving a concise description in the image description do that your audience could see this when they click on the images.

The diseases described in he clinical significance are interesting but they could use some images to support them. Perhaps you could go into more details about elastins exact role in some of these diseases. Great work all of you and I look forward to seeing your competed project.


Group 3:

The introduction has been done well, providing an intro into the topic of elastin fibers. It however is very short. You should consider expanding the text. You should also consider inserting a general image of an elastin fibre. The structure and component section is quite extensive. The content effectively demonstrates an adequate amount of research on this topic and is very informative. The Content in this section is correctly cited and referenced. The assembly section has also been down well, with the pictures standing out. The colours used and the numbers cited in the text aid in the teaching aspect by making this section more understandable. You should consider indenting the numbers in the text so that they stand out. While the section on function seems to be fairly extensive, some extra work should be done. The subheadings in this section effectively indicate a good understanding of the topic while help the reader follow this section. The images used are very good in visually aiding the reader. You should however provide a description of what is going in in the images and relate it back to a segment of the text. Some random phrases such as ‘Skin is composed of five layers’ should be revised. Further elaboration would be beneficial in this case as the text under skin is quite short. The section on clinical significance has been done very well. The division into diseases makes it easier to read. Not too much is needed to fix this section, however the student should consider adding some images to aid in the teaching aspect and provide a visual representation.

This project as a whole has been done quite well. The choices of headings used are quite good, but you should consider adding a bit of history and current research to indicate a good understanding of the topic. The subheadings used indicate a good understanding of the topic. The content effectively demonstrates an adequate amount of research on this topic and is very informative. Furthermore the information is quite detailed going beyond basic science while relating back to the cell biology aims. Overall a wide variety of pictures have been used including drawing and histological diagrams which add an element of teaching. Some sections do however need additional pictures and descriptions. The Content is correctly cited with in text citation used throughout the wiki page. The references are also done correctly except for a few missing references at the bottom (23, 24 and 25). Overall some extra work in each section will make this a great project. COLOUR CHART

http://meta.wikimedia.org/wiki/Wiki_color_formatting_help


https://www.youtube.com/watch?v=o05kRbVeg7A