Talk:2013 Group 7 Project

From CellBiology

2013 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

  1. Do not remove this notice {{2013 Project discussion}} from the top of the discussion page.
  2. Newest student comments should be entered at the top of this current page under the subheading "Student Discussion Area" (you cannot edit the sub-heading title).
  3. All comments should begin with your own signature button, that will automatically enter student number date/time stamp.
  4. Do not use your full name here in discussion, if absolutely necessary you may use first names only.
  5. Do not remove or edit other student comments.
  6. Use sub-headings if you want to add other draft information, images, references, etc.
  7. Only your own group members should edit this page, unless directed otherwise by the course co-ordinator.

Group Assessment Criteria

  1. The key points relating to the topic that your group allocated are clearly described.
  2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  3. Content is correctly cited and referenced.
  4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  6. Relates the topic and content of the Wiki entry to learning aims of cell biology.
  7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
  8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  10. Develops and edits the wiki entries in accordance with the above guidelines.

Week 2 Project topic selection, preliminary researching on the topic.

Week 3 By the next practical class (after the mid-session break) there should be sub-headings and content on your actual project page and interactions between individual group members on this discussion page.

Week 4 Each group member should now have selected 4 papers relevant to their section of the project. These, or any other papers, can now be used to generate content (text, images and tables) within the project page. Students can also work on additional sub-headings on the project page.

Week 8 Peer assessment of group project work.

  • Each student will carry out an assessment of all Group projects other than their own.
  • This written assessment should then be pasted on the actual project discussion page and your own individual student page.
  • The peer assessment for each project should be concise and include both positive and negative critical analysis of the current project status.
  • The actual assessment criteria (shown above) can be used if you like.
  • Each student assessment should be your own work and be completed before the next Lab.



Student Discussion Area

If I never talk about mitochondria again. I'm okay with that. Ive touched it up according to the reviews. Ive added a glossary. I need to do other assessments so my contributions are gonna slow down now. --Z3374173 (talk) 16:59, 24 May 2013 (EST)

Group 7 Really nice! I really enjoyed going through your page. The formatting is great and it is all written quite well. I like your use of subheadings, they break down the info effectively. All your sections are really good and your use of images is also very well done. Good referencing! All your sections are simple and concise which I really like. Overall, really good job!

--Z3451879 (talk) 16:01, 23 May 2013 (EST)

Group 7

Introduction- Good intro. The image needs a caption or something to help explain.

Structure - Good writing and referencing. Maybe some formatting to make it look prettier/ easier to read. Overall nice and concise.

Function - Nic formatting and separation of topics here - there was a ton of info and this made the reading easier.. Good diagram

History - Great coverage here. Nice referencing and very informative.

During Division- Well written and referenced. could use an image or two because it’s quite a bit of information. An image would break it up nicely.

Fission and Fusion- Really nice formatting - made it nice and simple. No complaints for this section.

Significance - Some bits need references for specfic statements.

Disease - INteresting little bit here at the end. I found it very informative and it ties the project together nicely.

--Z3330795 (talk) 14:42, 23 May 2013 (EST) Group 7

The key points are not well identified and there is a lack of consistent structure. The referencing is extensive and reflects significant depth of research. This groups page is extremely text heavy and this aspect of presentation must be addressed. There is obviously alot of research evident but this level of understanding isn't reflected, There must be different vectors to deliver this information. The above and beyond teaching requirements is not evident as this page appears to be quite boring to go through.

Group 7 feedback Introduction seems ok. May be replace the discovery table beneath the introduction. "Structure and function" of mitochandria is presented well in depth with relevent pictures however there is a need to reference in some parts such as "the citric acid cycle". If some or even one image is included in the section "during cell division" would make it more appealing for the reader. Further comments: providing a short brief description under each image would help the reader as well as the student in understanding of this topic. Overall this project has suffieceint information and easy to comprehend.

Group 7 Introduction

  • Good introduction. Explained well what a mitochondria is and why we need it. It was a bit on the long side and I felt the explanation of why we need ATP could afford to be summarised into an even smaller section of the paragraph.
  • the issue with the picture needs to be sorted out.
  • I feel like the heading implies that the mitochondria is a process or essential organelle of mitosis. Maybe a heading more like ‘The mitochondria and its behaviour during mitosis’ might be more appropriate.


  • Contained all the necessary information and nothing more (which is a good thing!). My only issue was that it looked and read like a ‘chunk’ of information. Separation into smaller paragraphs would help.


  • The opening sentence is a little confusing. It might help to break this into smaller, more cohesive sentences.
  • Good use of subheadings. Broke up this section nicely. Information under each subheading is overall, very good. Well done.
  • the citric acid cycle pargraph requires referencing
  • The picture of the citric acid cycle would work better as a thumb with a small explanation underneath it. Same goes for any other picture that isn’t a thumb.
  • The explanations of the complexes under sub-sub headings worked well. Made it easy to take in the large amount of information.


  • Good section. Simple and effective table. Colours aren’t offensive to the eye.
  • Find out how to make the table fit within the constraints of the page. At the moment, the width stretches beyond that.

During cell division

  • Intro was good, explained what retrograde and anterograde was. Not too much information for an intro either.
  • Overall good information. Relevant and detailed.
  • Referencing was a bit suspicious. Was all the information really from that first reference? It wouldn’t hurt to add more references if they were used (appropriate ones of course).
  • A picture or two would help break up the text.

Fission and fusion

  • Overall, a good analysis and comparison of these two processes.
  • Good use of subheadings. These sections weren’t an overload of information, they were succinct.
  • Seems well referenced!
  • Good picture

Physiological significance

  • This section is overall pretty good. Good structure and lyout to the information. Well referenced.
  • As always, pictures help information look good and also back up what is written.


  • A very good section to have. An interesting read and very relevant. Detailed without being over-the-top. Not much criticism for this section.
  • I thin this section should be its own section and not a sub-section within physiological significance.

Peer review

I think your introduction is really succinct and easy to read. It really introduces the topic well! I think that the fucntion is really brief and has some good references there. This ensures that its easy to understand and keeps the reader interested! You've incorporated the images well with the text and it help breaks it up! Your history section is really extensive and impressive ! In your during cell division section, I think the content is really good but I would probably suggest that you add an image or two to help explain the text - the same with the mitochondrial fission and fusion. I think the diseases you have discussed are really good and really informative! Overall I think its a good page and the only things to mkae it even better would be to add some more images and to add a glossary!

Group 7

Your information are well organised. The only comment I can say is do not try and include acronyms without introducing them first and talking about the functions. I know you can find this in the glossary, however your information would flow really good if you include a brief introductions of acronyms before including them. I am not saying that it goes to all the acronyms that you have included because you have successfully introduced quite a number of them. However, you should take in mind that the people who might need your information would have no idea about the biochemical acronyms. One more thing, I just like to point out to try and balance the information and images content. I know that our proctor removed some of your images due to lack of copyright but try and add images again before the time because you might hav good information but lack of images makes it boring. Overall, well done group 7!!

Group 7

Introduction Nice intro, briefly outlining function and providing an overview. “But more on that later when we discuss the function of mitochondria.” No need to include this sentence, let’s keep the page formal. The intro just needs a proofread

Structure and Function – Great info included here, although the image included in structure does not help me understand the info as it has no labels... thought about combining these sections? Also, keep it in the third person. Do not speak in first person “i will briefly”.

History – can the history section come before structure and function. An image here of one of the key scientists would be great.

Mitochondrial Fission and Fusion great info here, shows you’ve researched the topic thoroughly, the image included needs a caption describing it briefly.

Physiological Significance of Mitochondrial Division Great section, well researched and well referenced. Just needs a proofread. “Huntington's disease, an autosomal dominant and fatal neurological disease has also been associated WITH mitochondrial dysfunction.”

Overall a nice looking page with some great information. Once finished it will look boss.

z3377769 Group 7 assessment

Group 7 1. Content and writing - Intro o Fix up that image o Do you mean they are all passed down the maternal line? o Very good intro - Structure o Would prefer to have an image which actually labelled parts of the organelle o Very good indeed - Function o B-oxidation  What is the TCA cycle? have it in brackets o Glycolysis  I thought the substrate was ready for citric acid cycle?  First sentence is a bit informal  If the TCA cycle is a continuation of glycolysis then why haven’t you put the TCA cycle first? o TCA cycle  Love the image! Makes life far more understandable  If you can have sub/superscript for CO2 and H+ you may as well. o Electron transport  Keep it a bit more formal, “Let talk about…” isn’t the correct tone. o Complexes  I: Why have you waited so long to define what NADH is?  Good  II: good  This section is all very good, as is the image, keep it formal. - History o Great, not too much information in each time point, if you can find more to fill in the gaps, 1963-1981 and 1996 onwards that would be even better - During cell division o Intro:  All eukaryotic cells require mitochondria don’t they?  Good o Retrograde  Good o Anterograde  Maybe a table? Comparing anterograde and retrograde?  Otherwise this is well written and referenced o Fission and fusion  Table? Just to break up the text, I’m not saying put tables in everywhere but it’s an idea  Fusion • Fission comes first in the title, why not in the subheadings? • Mfn1 and 2: o Lovely • OPA 1 o Are Mfn’s mitofusions? o Fission  Fission in yeast and mammals sections aren’t consistent with the rest of your formatting - Physiological significance o Where are the rest of the references for the second paragraph? o Very good - Division in disease o This is a great section, really interesting, like the way you have stuck to the mitochondrial mechanisms involved in the diseases - Your project is solid, plenty of work has been done, there is always some cleaning up to do but this is a very good start. What about a future research section or a glossary, or further reading just to add some more depth to the project. In a couple of sections the tone is a bit causal but overall this is good stuff. 1. Referencing - You have an enormous amount of references, good on you, very well read, only a couple of paragraphs could do with more referencing. - Images have all the referencing and copyright information needed. Make sure they all have captions and apply to the section they are adjacent to. 2. Elements of teaching - This is pretty technical overall, probably at the limit of what I can understand but that is fine, I would include a glossary and make sure you define all the anagrams like NADH or TCA, etc. 3. Presentation - As I said there are opportunities for the use of tables in a couple of areas, I wouldn’t go mad and put them everywhere but one more I think would break up the paragraphs a bit and make it more readable

z3374507 assessment- Group 7

Most of key points concerning mitochondria during cell division are thoroughly addressed.

The content is informative and relevant to each section. This demonstrates that the group has conducted a significant amount of research.

The images supplement the text well.

The text and images has been referenced well.

The balance between texts and images could be improved by adding a few more images (specifically to the introduction and structure sections).

Also changing the positions of some of the images and adding a brief statement to describe the illustrated processes will improve the formatting.

Finally, adding a section for current and future research may improve the page.


  • Good summary of what mitochondria are and their function
  • The image for this section doesn’t appear to be correctly entered


  • Info here is well summarised and provides a good description of the mitochondria and its features, easy to follow and understand
  • An image to accompany what is described would be useful, perhaps a student drawn diagram of the structure


  • Provides very good and detailed summary of the functions but I don’t think all the details are necessary. The project should be more focused on what happens to mitochondria during cell division. Maybe you can cut this section down a little, may be include the detail of the processes in the image legends?
  • Also, shouldn’t really be a first person account (i.e. saying “I will briefly discuss..”)
  • Images are good, displaying all the info required. The legends could have more detail. The second image just needs to have proper referencing not just a link to the paper
  • Some of the subsections don’t seem to have references


  • Really good timeline, nice and succinct showing all key discoveries. No major gaps in time so it flows well
  • May want to fix “1937: Citric acid cycle formulated by Krebs, aerobic phosophorylation described by....??”
  • The timeline could extend a little further

During Cell Division:

  • Good summary, may need to use more of a variety of references
  • The Retrograde and Anterograde headings could stand out a little more by making them subheadings (using ===)
  • An image could be used here to break up the text

Mitochondrial Fission and Fusion:

  • This section has been well researched, just feel that it needs a little more description of what fusion and fission are and their role in cell division
  • There’s also a lot of terms which need to be defined in a glossary
  • Good accompanying image with all the necessary info

Physiological significance of Mitochondrial Division:

  • This section has also been well researched and contains very interesting info
  • I feel more images could enhance this section, possibly ones that show the physical effects of the different diseases
  • The image here has been properly referenced and contains all the necessary info but could use a more descriptive legend

Overall, the topic has been researched well, with good use of subheadings, though I think there needs to be more focus on the cell division and mitochondria. Really need to include a glossary and more images to break up the text. Also could use a section describing current and future research in the area of mitochondrial division and maybe some links

Criteria: 1. The key points relating to the topic that your group allocated are clearly described. 2. The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area. 3. Content is correctly cited and referenced. 4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations. 5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities. 6. Relates the topic and content of the Wiki entry to learning aims of cell biology.

Very thorough page, and you guys address the important issues that may come up when the mitochondria gets discussed, ranging from the function to structure then what happens to it during cell division(1) There is not too much text on your page and this is often a good thing - visitors won't be so overwhelmed by the sheer word volume, but I think you guys could make it even better with some more images perhaps? I think a nice photograph of a mitochondria might be nice instead of just cartoons, maybe one near the top to catch people's attention? I like how you have explained the scary TCA cycle diagram! Very useful to students!!! Amazing timeline! Maybe you could add a light colour instead of the gray just to liven it up? Small grammar errors you guys might wanna just double-check before the due date. Also you might want to try going over the references and moving them around so they're not just hanging off the ends of sentences/paragraphs - move them to where they are relevant within the text. Many are piled up, for example references 32-36 are named one after another, if you were reading your page would you be able to follow along with them like that? Large headings for very small amounts of text, sure this is good, but if it's important enough for a large heading then maybe it warrants elaboration?(2)Outstanding reference list, correctly done and demonstrates extensively thorough research and effort! No duplicates anywhere!!!(3+5) Since you have covered most issues about the mitochondria as I previously mentioned, its very suitable for learners and people who just want to brush up on it, so well done with this!(4) The mitochondria is important to cells as ATP is required for many important cellular functions, so well done on your choice of topic; it is relevant to cell division and looks to be coming along nicely(6)

Peer Assessment

Group 7-Mitochondria


  • The image in the introduction is not there maybe upload it again or upload another one.
  • There are some mistakes in the text at the end of the section.
  • The introduction is relevant to the topic.
  • You might want to briefly talk about what the project will have (the main heading).
  • Add an image.


  • The structure is written well and is referenced well.
  • Possibly upload a student made image here.
  • The image uploaded doesnt offer as much as another image could. You might want to uplaod or draw an image with labels of the structure you are mentioning.


  • This section is referenced well
  • Maybe make a table for all the complexes.
  • You might want to take out the part "i will discuss" and reword it.
  • Need to write descriptions for the images uploaded.


  • The table is very informative which is excellent.
  • Each point made is supported with references except for 1990.
  • Add more points after 1996.
  • The information is very relevant to the topic.

During Cell Division

  • The information is relevant and referenced well.

Mitochondrial Fission and Fusion

  • You refer to Fusion and Fission with capitals during the paragraph and sometimes use the terms without having capitals.
  • Research is very good and succinct.
  • I feel it would be better if you compared the two processes directly rather than talking about each separately.
  • Good use of sub headings

Physiological Significance

  • There is a lot of information here that is very detailed and excellent as it shows the research you have done.
  • The image uplaoded supports the information
  • Include a description for the image you uploaded

Overall The project is on the way towards completion. You seem to be missing Current and Future research but apart from that there are only minor changes that need to be made to this project.

Group 7

Introduction: This is a well written introduction however there were some grammatical errors. Also, there is an issue with the thumbnail that needs to be fixed. The elements that you will be exploring in the wiki page should be made clearer.

Structure: This section is well written and the information is quite good. I really like the image that has been used. It is correctly referenced.

Function: The citric acid cycle has no references and should be addressed. I like the use of headings and subheadings. The information for the complexes could be presented in a table perhaps.

History: I think the history table should be under introduction. Its current position seems out of place. I enjoy the colour scheme since it allows the reader to easily see the words.

Mitochondrial fission and fusion: The level of information is great. However, I think a more effective way of presenting this information is in table format.

Disease: This section shows extensive and in depth research.

Further comments: Some of the references repeat in the list. To further improve the element of 'teaching at peer level,' a greater description can be provided for each image to show the student's understanding of the image and how it relates to their topic.



  • Yes, it's obvious there's been an error with the first image, File:ElectronMicroLungMitochondria.jpg. The image could be missing from the database so you might have to catch up with Dr. Mark Hill to fix it or re-upload the same image under a different name.
  • It's clear and concise which should be the point for all introductions. I have an issue with the references which I have addressed further down.


  • I feel that definitely History should come directly after the Introduction.
  • Maybe this image should replace the Introduction as it looks a lot more simple.
  • A labelled image pointing out all the parts of the mitochondria would be good.
  • Have you considered a table format which could make it easier to read and label?


  • Under Glycolysis, you shouldn't refer to first person.
  • You didn't explain what TCA stands for before abbreviating it.
  • The main function of mitochondria is to produce energy for the cell, I actually can't follow this section well to understand how that happens.
  • Doesn't mitochondria have multiple functions inside the cell besides producing energy?


  • As said before, would be better if it came directly after Introduction.
  • There's a good amount of dates spread out.
  • Maybe something after the year 2000.
  • I have issues with the references listed below.

During Cell Division

  • Shouldn't this section be more detailed? The whole 2013 group project is to do with cell division and it's only given a small section to relate back to the main topic. Does anything before cell division? Afterwards?
  • Needs an image to show the difference between retrograde and anterograde, I can understand if that can be difficult though.

Mitochondrial Fission and Fusion

  • I feel this sentence needs to be re-worded so I can understand the relationship to cell division, "enable the organelle to change in morphology, activity and distribution outside that of the regular cell replication and division process."
  • Fusion and Fission headings shouldn't be capitalised.

Physiological Significance of Mitochondrial Division

  • This is a good lead up from the previous heading Fission and Fusion.
  • Maybe rename the heading differently. Mitochondrial Abnormalities or Mitochondrial Diseases?
  • Should add a Current and Future Research section.

Formatting Issues

  • You need at least one student drawn picture.

"Note that the group project requires the inclusion of at least one student drawn image (from the group)."

Refer to this part of the website for tips:

  • For all images you should put it in a thumb picture so you can provide a quick explanation and also use the reference line after that description. It should look like this:

[[File:picture.jpg|thumb|short description of picture being displayed<ref><pubmed>XXXXX</ref></pubmed>]]

  • All references should be directly after the full stop (it's a little format issue but will be noticed).
  • Needs more images, I know it can be hard finding images with copyright being the main issue but there are other ways to get some relevant pictures.
    • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
    • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.

But it's a tad overboard. Look at the History section under 1955. It has 5 references glued together! Looking at the sources it's all from the same book but each source was from a different volume. Was it really necessary to label all 5 volumes for two sentences?

Looking at reference 1, in the Intro alone it's repeated 3 times! And again with the Anterograde section, 4 times! These are all repeated in the one single paragraph too. Dr. Mark Hill clearly said, he absolutely hates the same reference repeated endlessly in a short amount of time and there's a good chance you might lose marks from doing this.

I know whoever did this must of spent a lot of time and effort, but I am genuinely concerned it might have done more harm than good.

--Z3293267 (talk) 01:24, 23 May 2013 (EST)

z3374087 assessment

The introduction is extensive and concisely addresses all aspects of the groups “cell division” project including structure and function however it requires a brief history and what the project is going to address in regards to cell division. The “structure” subsection is very detailed but just one huge chunk of information. Try putting this into bullet form to break up the information and not let the reader become uninterested right at the beginning of the page. The “function section” is absolutely perfect. It is divided into short paragraphs which allow the information to flow and is supported by relevant pictures that aid in understanding these processes detailing cell division. The “history section” is also perfect and contains all relevant information however it needs to be relocated right to the beginning of the page because it is in the middle of nowhere. By having at the beginning it will provide a general background for the information that is going to follow and allow the reader to gain an appreciation for the research that has gone into cell division. For the “during cell division” section the retrograde content requires more information and accompanying pictures. A picture is also required for the anterogade heading which is very detailed. The “fusion and fission” sections address all necessary information however the picture provided does not have much reference to the steps provided. Try finding pictures that detail the steps during fusion and fission and don’t forget to add a caption under the picture describing what the picture is illustrating. The picture provided does not have a caption. Add a heading describing the diseases associated with mitochondrial division along with pictures illustrating the ultimate physical outcome of the diseases. A glossary is required. The references are plentiful and some really great sources are used. Overall this assignment needs many pictures and some restructuring of headings and paragraphs but is definitely at a Distinction level at the moment.

Group 7 Assessment

Straight away, there is an error for one of the photos in the introduction. Should be resolved. Aside from that, introduction was well-written and explained the topic of cell division mitochondria well. Structure information was well-written except for the end where it tapered off. Picture should be aligned properly and at least labelled to say it was a mitochondria. This seems to be the case with most of the photos and diagrams in the page. Quite impressed with the function section as it was divided into different parts and well explained under each. Breaking up the sections really helped in reading all that text. History table then followed which was a little odd (the flow) but the table was complete with relevant events. It could use some images so that it does not look just like a bunch of sentences. The During Cell Division section did seem to explain the stage very well but once again, lacked images so it was very difficult to read. As for the fusion section, it was a good idea to break up the fusion and fission sections but maybe this would be better in a table so one can clearly see that it is two different stages. Other proteins section could be formatted better. Physiological significance part was written well but it seemed a little odd to have mitochondria division in human diseases as a sub-heading underneath it. May be a formatting mistake. Information on the diseases was well-written but would benefit from images of how the diseases manifests in the human body. Almost all of the information in the page is present in the discussion page which is good but there is also some discussion as well. Either way, this page could add more subsections to their topic because it seems to be slightly narrow, but still does a good job.

Peer Review

Group 7: Mitochondria

Intro: It seems good so far, but the text is so condensed and there’s not a lot breaking it up. Also, sentences like “But more on that later” don’t really make your intro flow well. It’s kind of a redundant statement because we already know that you are introducing what you’re going to talk about.

Structure/Function: There is a lot of very detailed information here which is good and diagrams are relevant.

History: There is nothing in the table after 1996, maybe you haven’t finished this section? On that note, I noticed that there is no section for current/future research. As mitochondria are an interesting topic, it would be nice to have some information about current developments.

During Cell division: This section seems to be a bit short considering that this should be the main focal point of the page. Pictures would be to your benefit here.

Physiological: This section is well-written and comprehensive. The information is interesting as well as being relevant.

Group 7 – Mitochondria

The introduction is appropriate and concise and has appropriate referencing. There is an ‘error’ for the thumbnail image, you need to fix it soon.

The structure section is a good start but is a little brief. Perhaps you should add a bit more information and an image to support the text.

The function section is very detailed and has appropriate referencing. The images are also relevant and support the text and has appropriate referencing. The history section is reasonably good so far, with appropriate referencing for the discoveries.

Perhaps adding some images to support some of the discoveries would make this section look more interesting. The table format is a good idea. However the table is going off the page on the right side, you need to fix that.

“During Cell Division” section is reasonably detailed and has appropriate referencing. It would be good to add an image to support the text, as there is a lot of text to read.

“ Mitochondrial Fission and Fusion” section is also very detailed and has correct referencing. However the thumbnail image in this section does not have a label to describe what it is. After clicking on it, i can see the description then. The referencing for the image is correct.

“Physiological Significance of Mitochondrial Division” is also very detailed with correct referencing. However there is only 1 image in this whole section. Perhaps you should add another image to balance the text.

There is no current research section in your page. You should have this section and summarise some recent research papers on mitochondria, along with some images from those papers.

There is also no glossary section in your page, you need to have a glossary to make it easier for people to understand some words that are difficult to understand.

Overall the project is very good, but needs a bit more work.

Group 7: Mitochondria

  • Introduction: Your introduction is well written because it does explain the importance of mitochondria, e.g. it’s an organelle that is involved in the generation of ATP and basically the survival of the organism more or less depends on it. Though the very last sentence has a few grammatical errors that need to be corrected and you have not made the aim of the wiki page clear (you need to state that you will be exploring the mitochondria etc.) Also, your image has not been uploaded properly (there is a thumbnail error, so please ensure your fix this before next week!)
  • Structure: I can see that you have some good information on the different structures of the mitochondria (Inner and outer membrane, the matrix etc. ) though maybe it would be more effective and clear if you present the information in a table format. Divide the table into different headings suc as descriptions and function, and then talk about each of the structures. Also, try to include an image of mitochondria or even draw one yourself because you need to include at least one student drawn image.
  • Function: the opening sentence is very long and also when you talk about glycolysis, you shouldn’t really be using the word ‘’’I’’’. Also, maybe it’s a good idea to link glycolysis with the citric acid cycle (combine the information) as you have to many sub-sub headings. Also, you’ve provided some god images that show the mitochondria and illustrate the TCA cycle but you haven’t provided any descriptions to explain what they are presenting (some reader may not know that it is the TCA cycle). Also, the information in this part of the project page has hardly provided any references which need to be addressed.
  • History: Your history section is has a great colour scheme but unfortunately you haven’t provided any information after the year 1996. You need to complete the table with relevant and up to date discoveries etc. Also, I think it would be much better if you placed the information straight after the introduction.
  • Mitochondrial fission and fusion: So here you have some great information about the different genes and proteins involved in fission and fusion such as the Fzo1, Mfn1 et. Which I recommend would be more user friendly and better explained if you use a table to present the information. Divide the table into similarities and differences between the fission and the fusion processes. Finally, it is good to see that you have explained what the image is showing- you need to do this with all of the images on the page.
  • Physiological division in human diseases: This section has been well referenced though maybe it would be a good idea to cut back on some of the information on Drp1 because you go into a lot of detail which is not very user friendly. Also, the information for neurodegenraqtion mechanisms needs more references; there is only one reference for the entire paragraph.
  • Extra comments On your wiki page you need to include a sub-heading for current research and glossary and you should provide the relevant information for each section. Also, you do not have any student drawn images (which is essential to include). Finally, I strongly recommend including an external link to a YouTube video on the function of the TCA cycle because your information can confuse students and wiki users that are not familiar with the TCA cycle.

Peer assessment: There are sufficient citations used. It would be great if there some diagrams were added into introduction and the structure sections. The citations in B-oxidation, glycolysis, the citric acid cycle and electron transport chain? The history section is good. Maybe cite some articles for 1898,1988 and 1990. “During the cell division” section: If the a mitochondria ….. (grammatical error) Overall, I think that the project has sufficient information and is good. The information is easy to understand and concise.

does anyone know how many references we can use with a textbook? --hey guys i am starting on the intro/structure/function section-- --Z3374173 (talk) 16:47, 21 March 2013 (EST) Grace Possible Options??


--Z3374173 (talk) 15:56, 28 March 2013 (EST)

--Z3359076 (talk) 15:57, 28 March 2013 (EST) Leticia

Mitochondria during cell division? Confirmed?

--Z3359076 (talk) 16:06, 28 March 2013 (EST)

What needs to be done / researched on:

Intro - What is mitochondria, functions, shape, membrane structure

History - discovery, how it relates to cell division especially

How it divides in mitosis and meiosis

How it breaks down (if it breaks down?)

How it reforms?


Study techniques

Current reserach

  • Remember to separate research articles from review articles! Do not cite results from review articles.

--Z3223095 (talk) 16:27, 28 March 2013 (EST) did we also want to do something about regulation? Hey guys, im starting to do topic 1- the intro/shape/function

--Z3359076 (talk) 09:42, 10 April 2013 (EST) Hey, I'm working on mitochondrial division mechanisms and the physiological functions/effects of mitochondrial division.

--Z3374173 (talk) 14:22, 10 April 2013 (EST)

Mitochondrial fusion and membrane potential.png

<pubmed>16704336</pubmed> This paper explains and suggests important theories about the processes of mitochondrial fusion and fission, Which may control the shape but also the function of the organelle and how it functions with other mitochondria. It's a review article about the dynamics of the mitochondria and how they interact with each other, and it also identifies the main components of the parts involved during fusion and fission

<pubmed>10531006</pubmed> This paper suggests that that mother cell retains an amount of mitochondria but stopping a potion of the total amount of mitochondria in whats called the 'retention zone' of the mother cell. This process require an actin cytoskeleton. This study investigates how the mother cell retains the mitochondria. Their results show that equal amounts of mitochondria are split between the the two cells. This is done by two actions of the actin skeleton, The retention and the movement of mitochondria.

<pubmed>16624426</pubmed> This study is about the movement of mitochondria within a cell and how it interects with the actin cables. This could occur in cell partition or in normal cell function. This functions as a movement of mitochondria to places of higher ATP synthesis or keeping them stationed at one place for the same reason

<pubmed>15254264</pubmed> Really good article on both meiosis and mitosis and how the mitochondria work and a good overview. It tells of how mitochondria fragment and rejoin during meiosis and how even though defects in some of the properties will cause the mitochondria to fall to one side of the cell and fail to fragment, some will still complete meiosis.

<pubmed>11700280</pubmed> Really great review on the overview of all possible process. This would be a great starting point. Just a review article, not really one of my main 4 but very good on information

--Z3359076 (talk) 20:21, 10 April 2013 (EST)

<pubmed>19679814</pubmed> This article demonstrates the mechanistic role of DRP-associated proteins using the yeast mitochondrial division as a model. The study explains the specific interaction of protein Mdv1p with GTP-bound Dnm1p and the promotion of Dnm1p assembly onto membranes of mitochondrial, providing clear evidence of the function of Mdv1p in the mitochondrial division mechanism.

<pubmed>19752021</pubmed> This study demonstrates the physiological function of mitochondrial division in the embryonic and brain development of mice. It also describes the study of the first Dynamin-related protein 1 knock-out mice.

<pubmed>22564413</pubmed> This article provides good findings to prove that mitochondrial division plays a key role in promoting neuronal survival by suppressing oxidative damage in postmitotic neurons. The study of how mitochondrial division affects mammalian cells is one of the latest interests of researchers.

<pubmed>21565481</pubmed> This review article gives an insight to the molecular machinery of mitochondrial division and how mitochondrial division contributes to cellular functions and diseases. It serves as a good starting point for this research project.

JCB 201110034 Fig10.jpg [1]

A model for neurodegeneration caused by mitochondrial division deficiency.

1.Observations on Mitochondrial structure

This paper talks about the occurrence of wrinkles on the membranes of the mitochondrial cristae. It discusses the structure and placement of the cristae and how that changes its function. It goes on to talk about where it may occur; for example: an exaggerated expression of this tendency for angulation of the internal mitochondrial membranes is found in certain bat muscles where some of the cristae take the form of parallel bundles of prismatic tubules which are triangular in cross-section. Mitochondria

2. Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis.

This paper discusses how Mitochondria are at the epicentre of metabolism and how the mitochondrial function must adapt to the ever changing cellular environments. The biological signals that start the mitochondrial changes and the cellular processes that drive this adaptive response are largely obscure. All together it talks about how their work reveals that cellular iron is a key regulator of mitochondrial biogenesis, and provides quantitative data. <pubmed>23318259</pubmed>

3.Mitochondrial disorders as windows into an ancient organelle.

This paper discusses the mitochondria within patients who have respiratory chain disorders. These disorders are rare syndromes which present in unique ways. It goes on to discuss further on the disorders and in the context of mitochondrial evolution, biochemistry and genetics. <pubmed>23151580</pubmed>

4. A chemical screen probing the relationship between mitochondrial content and cell size.

This paper discusses how the cellular make up of mitochondria undergoes many changes during development and also in response to external stimuli. It continues to explain how they went about identifying probes and pathways that control mitochondrial abundance. They screened 28,786 small molecules and observed their capability of increasing or decreasing the cellular content of mitochondria according to cell size, which exposed control of these parameters. <pubmed>22479437</pubmed>

Electron transport chain.png

hey guys, I have touched on the intro and the structure. I am not sure how deep I have to go into everything? Also, I am having trouble where i can find the reference guide for textbooks, does anyone know?

--Z3374173 (talk) 21:18, 8 May 2013 (EST)

This is just my notes i need, Please dont delete theses!!!


Altmann, R. 1890 . Die Elementarorganismen und ihre Beziehungen zu den Zellen . Veit, Leipzig

--Z3374173 (talk) 17:54, 10 May 2013 (EST)

Okay, i have done so much reading for this subject its insane! Should see how many documents i have on my computer! I'll do the rest of the history and I'll start and hopefully finish the actin skeleton! Is the person who's doing the diseases going to explain more of them? Cause we need more fill, and i found some DNA linked diseases if you want them too. And ill see if i can find any pictures to put up. They all seem to be copyrighted so ill look ok PLoS and see what i cam find/draw something haha

--Z3359076 (talk) 20:52, 11 May 2013 (EST)

Yup, I'm reading thru the journals on the physiological functions and human diseases. Will do up that section by tmr.

this is so frustrating, sitting with 100 journals open, sifting through the relevent stuff when all the information is in the text book, aghhhh --Z3223095 (talk) 23:53, 13 May 2013 (EST) can anyone find any pictures relatede to mitochondria?

Time course of the fusion of mitochondria..png

I have some issues, im just planting this ere so i can talk with mark later. --Z3374173 (talk) 22:12, 15 May 2013 (EST)

Okay, so ive changed the referencing around so it looks nicer. Im going to do more on the actin skeleton tonight/tmr too --Z3374173 (talk) 18:03, 17 May 2013 (EST)

Sorry that I missed the last lab. I wasn't feeling well. I'll try to complete the human diseases section by tmr nite or monday too. --Z3359076 (talk) 22:33, 18 May 2013 (EST)

Have we got any more diseases? or has anyone found any pictures? I think we need more pictures. We're coming down to crunch time! --Z3374173 (talk) 20:46, 21 May 2013 (EST)

Yup, I will finish the diseases section by tmr. Might need help in editing the references after that to make sure that there is no repeating references under the references section. I agree that we need more pictures. Also, could we have more colours on the page? Maybe for the table under the history section? --Z3359076 (talk) 22:54, 21 May 2013 (EST) --Z3223095 (talk) 15:22, 22 May 2013 (EST) do you guys think we need more information on function? --Z3223095 (talk) 15:22, 22 May 2013 (EST)also i am going to put a basic drawing of the structure of mitochondria! if i drawer it, how do i reference it?

--Z3374173 (talk) 18:19, 22 May 2013 (EST) Okay sweet, the diseases look great! And yeah i can do that, just tell me when youre done and ill fix it up for you :) and yeah maybe more on function, we need function referenced! all the chain part needs to be referenced. And yeah a drawing will be great!! Put one up! i was going to do one but yeah you go ahead!! I also put in a picture at the top but it wont show up, I'm talking to Mark about that now so please dont touch it yet!

--Z3359076 (talk) 22:54, 22 May 2013 (EST) I'm done with the diseases section. Pls help me with the referencing =)

--Z3223095 (talk) 18:40, 27 May 2013 (EST) hey guys, i have added a few more sections in the function! do you think i should talk about apoptosis? --Z3223095 (talk) 18:40, 27 May 2013 (EST)can i help anyone with any section? and when is the project due?

--Z3223095 (talk) 07:20, 29 May 2013 (EST) funny thing, been researching for ALS in neuro and found information on apoptosis!

  1. <pubmed>22564413</pubmed>